Skip to main content

Brompheniramine

ADVERTISEMENT
Identification
Molecular formula
C16H19BrN2
CAS number
86-22-6
IUPAC name
(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine
State
State

At room temperature, brompheniramine is generally found in a solid state, often in the form of tablets or other medicinal formats.

Melting point (Celsius)
116.00
Melting point (Kelvin)
389.00
Boiling point (Celsius)
358.80
Boiling point (Kelvin)
632.00
General information
Molecular weight
319.25g/mol
Molar mass
319.2470g/mol
Density
1.1000g/cm3
Appearence

Brompheniramine is typically available as a white to off-white crystalline powder. It is odorless or has a faint characteristic odor.

Comment on solubility

Solubility of (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

The solubility of (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine is a critical factor in its application and behavior in various solvents. Here’s what we need to consider:

  • Polar vs. Nonpolar Solvents: This compound contains both polar and nonpolar characteristics due to its amine functional groups and aromatic systems. Therefore, it is expected to be more soluble in polar solvents such as water or methanol, but may also show some degree of solubility in nonpolar solvents like hexane.
  • Hydrophobic Interactions: The presence of the 4-bromophenyl group enhances hydrophobic interactions, possibly reducing solubility in highly polar environments, making it less favorable when mixed with very polar solvents.
  • pH Dependency: As a basic amine, the solubility of this compound may increase in acidic solutions. The protonation of the amine can enhance its solubility by increasing ionic interactions with the solvent.
  • Temperature Effects: Solubility is also temperature-dependent; typically, higher temperatures may increase solubility due to enhanced molecular motion, favoring dissolution.

In summary, the solubility of (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine depends on its environmental context. Its solubility traits can be succinctly quoted: “Solubility is a dance between polarity, structure, and interactions.” Understanding these factors is essential for its utilization in chemical applications.

Interesting facts

Interesting Facts about (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

This compound, an intricate example of organic chemistry, belongs to a class of molecules often discussed for their relevance in pharmacology and medicinal chemistry. Here are some interesting aspects worth noting:

  • Structural Complexity: The presence of both a bromophenyl group and a pyridyl group contributes to the compound's structural complexity. This can lead to varied interactions within biological systems, potentially influencing the compound's pharmacokinetics and pharmacodynamics.
  • Stereochemistry: With a specific configuration at the chiral center (3S), this compound showcases the significance of stereochemistry in drug design. Different stereoisomers can have drastically different biological activities, making this characteristic crucial in the development of therapeutic agents.
  • Potential Biological Activity: Compounds featuring amine functional groups, especially dimethylated ones, are often examined for their potential roles as neurotransmitter reuptake inhibitors. This particular compound might exhibit interesting interactions with neurotransmitter systems, such as serotonin or norepinephrine, warranting further research.
  • Halogen Influence: The bromine atom in the structure is known to impact the compound's reactivity and bioavailability. Halogenated compounds often display enhanced binding affinities to specific receptors, which can be crucial for their effectiveness as drugs.
  • Applications in Research: Researchers frequently investigate derivatives of phenethylamine due to their applications in the development of novel psychoactive substances, contributing to the understanding of brain chemistry.

In conclusion, the compound (3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine illustrates the interplay of structural features and potential biological activities, making it a compelling subject for ongoing scientific inquiry. As quoted by many chemists, “The structure dictates function.” This compound is no exception to that adage.

Synonyms
Dexbrompheniramine
D-Brompheniramine
132-21-8
Dexbromfeniramina
Dexbrompheniraminum
(S)-brompheniramine
(+)-brompheniraminum
Brompheniramine d-
(S)-(+)-brompheniramine
Brompheniramine d-form
Brompheniramine, (s)-
Desbrofeniramina
Dexbromfeniramina [INN-Spanish]
Dexbrompheniraminum [INN-Latin]
EINECS 205-053-5
UNII-75T64B71RP
CHEBI:59269
75T64B71RP
BROMPHENIRAMINE, (+)-
DTXSID8022905
(+)-(3-p-Bromphenyl-3-pyrid-2'-ylpropyl)dimethylamin
(+)-N,N-Dimethyl-(3-(4-bromphenyl)-3-(2-pyridyl)propyl)amin
(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine
Dexbromfeniramina (INN-Spanish)
Dexbrompheniraminum (INN-Latin)
(R)-3-(4-Bromophenyl)-3-(2-pyridyl)propyldimethylamine
desbromfeniramina
Dexbrompheniramin
DTXCID002905
R06AB06
()-(3-p-Bromphenyl-3-pyrid-2'-ylpropyl)dimethylamin
205-053-5
3-(4-bromophenyl)-n,n-dimethyl-3-pyridin-2-yl-propan-1-amine
(3S)-3-(4-bromophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
Dexbrompheniramine [INN:BAN]
[(3S)-3-(4-bromophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
3-(4-bromophenyl)- N,N-dimethyl- 3-pyridin-2-yl-propan-1-amine
NCGC00162100-02
(+)-Parabromdylamine
Lopac0_000232
SCHEMBL29345
(+)-Brompheniramine; (+)-Parabromdylamine; (S)-Brompheniramine
GTPL7588
DEXBROMPHENIRAMINE [INN]
CHEMBL1201287
DEXBROMPHENIRAMINE [VANDF]
DEXBROMPHENIRAMINE [WHO-DD]
BROMPHENIRAMINE D-FORM [MI]
PDSP1_000134
PDSP1_000135
PDSP2_000133
PDSP2_000134
AKOS015969654
CCG-204327
DB00405
SDCCGSBI-0050220.P002
NCGC00162100-01
NCGC00162100-03
NCGC00162100-05
DA-62806
NS00079570
AB00698453-08
EN300-25893693
Q5268318
3-(4-Bromophenyl)-N,N-dimethyl-3-(2-pyridinyl)-1-propanamine #
2-Pyridinepropanamine, .gamma.-(4-bromophenyl)-N,N-dimethyl-, (S)-
Pyridine, 2-[p-bromo-.alpha.-[2-(dimethylamino)ethyl]benzyl]-, (S)-