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chlorpheniramine

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Identification
Molecular formula
C16H19ClN2
CAS number
132-22-9
IUPAC name
(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine
State
State

At room temperature, chlorpheniramine is in a solid state. As a medication, it is often encountered in a solid dose form, either as tablets or capsules.

Melting point (Celsius)
130.00
Melting point (Kelvin)
403.20
Boiling point (Celsius)
410.50
Boiling point (Kelvin)
683.70
General information
Molecular weight
274.79g/mol
Molar mass
274.7880g/mol
Density
1.0805g/cm3
Appearence

Chlorpheniramine is typically found as a white to yellowish crystalline substance. It is usually available in the form of tablets or capsules for medicinal use, often formulated combined with other substances.

Comment on solubility

Solubility of (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

The solubility of (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine is of considerable interest, particularly due to its complex structure. Understanding its solubility characteristics can provide valuable insights into its potential applications and bioavailability:

  • Solvent interactions: This compound is likely to demonstrate varied solubility in different solvents, notably due to the presence of both polar and non-polar functional groups.
  • Aqueous solubility: The amine functional group may enhance its solubility in water, yet the chlorophenyl and pyridyl moieties may hinder it, leading to limited solubility in aqueous solutions.
  • Organic solvents: It is expected to be more soluble in organic solvents like DMSO (dimethyl sulfoxide) and ethanol, where non-polar interactions can dominate.
  • pH dependence: The solubility may fluctuate with changes in pH, influenced by the protonation state of the amine group, which could enhance solubility under acidic conditions.

In summary, the solubility of (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine presents a nuanced challenge, attributed to its intricate molecular structure and the mixed polarity of its functional groups. Understanding its solubility can greatly assist in predicting its behavior in pharmacokinetic studies and formulations.

Interesting facts

Exploring (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine

The compound (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine, often referred to as a derivative of propan-1-amine, is intriguing due to its complex structure and potential applications. Here are some fascinating aspects of this compound:

  • Stereochemistry: The designation "(3S)" indicates that this compound has a specific stereochemistry, which can affect its reactivity and interaction with biological systems.
  • Pharmaceutical Relevance: Compounds like this are often investigated for their pharmacological properties. The incorporation of both a chlorophenyl and a pyridyl group suggests potential *bioactive properties* and interactions with various receptors.
  • Structure Activity Relationship: The presence of functional groups—such as the chlorophenyl moiety—can significantly influence the compound's activity, making it a prime candidate for studies in medicinal chemistry.
  • Research Applications: Compounds with similar structures have been studied for their effectiveness in treating conditions such as depression or anxiety disorders, providing a platform for further exploration in drug development.

As we delve deeper into the study of this compound, we can ponder the importance of *molecular configuration* in determining chemical behavior and efficacy in therapeutic applications. Combining elements of organic synthesis and medicinal chemistry, (3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-(2-pyridyl)propan-1-amine stands as an exciting target for further research.

In conclusion, understanding the nuances of this compound can unlock new avenues in pharmaceutical development, providing essential insights into *how small changes in structure can lead to significant differences in biological activity*.

Synonyms
DEXCHLORPHENIRAMINE
25523-97-1
D-Chlorpheniramine
(+)-Chlorpheniramine
Phendextro
Dexclorfeniramina
Dapriton
Fortamine
Isomerine
Polaramin
Dexchlorpheniraminum
Chlo-amine
Chlorpheniramine, d-
Chlorphenamine, (s)-
Chlorpheniramine, (s)-
(3S)-3-(4-chlorophenyl)-N,N-dimethyl-3-pyridin-2-ylpropan-1-amine
CHEBI:4464
3Q9Q0B929N
D-2-(p-Chloro-alpha-(2-dimethylaminoethyl)benzyl)pyridine
DTXSID50180225
2-Pyridinepropanamine, gamma-(4-chlorophenyl)-N,N-dimethyl-, (S)-
(+)-N,N-Dimethyl-(3-(4-chlorphenyl)-3-(2-pyridyl)propyl)amin
dexclorfeniramine
desclorfeniramina
Chlorpheniramine d-
dexchorphiramine maleate
RefChem:54962
DTXCID60102716
R06AB02
247-073-7
Polaramine
Chlorpheniramine d-form
Trenelone
Dexchlorpheniramine (INN)
DEXCHLORPHENIRAMINE [INN]
(S)-gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine
(S)-(+)-2-[p-chloro-alpha-[2-(dimethylamino)ethyl]benzyl]pyridine
Dexchlorpheniramine [INN:BAN]
Dexclorfeniramina [INN-Spanish]
Dexchlorpheniraminum [INN-Latin]
HSDB 3054
EINECS 247-073-7
UNII-3Q9Q0B929N
d-Chloropheniramine
Dapriton (TN)
SCHEMBL3538
Lopac0_000264
BIDD:GT0027
(+)-3-p-Chlorphenyl-3-pyrid-2'-ylpropyl)dimethylamin
GTPL1210
orb1710683
CHEMBL1201353
DEXCHLORPHENIRAMINE [HSDB]
DEXCHLORPHENIRAMINE [VANDF]
DEXCHLORPHENIRAMINE [WHO-DD]
BDBM50247890
CHLORPHENIRAMINE D-FORM [MI]
EX-A10889
PDSP1_000611
PDSP2_000608
AKOS025310177
CCG-204359
DB13679
SDCCGSBI-0050252.P003
NCGC00162110-01
NCGC00162110-02
NCGC00162110-03
NCGC00162110-07
DA-62807
SBI-0050252.P002
HY-117501
NS00098761
C06946
D07803
AB00698452_07
AB00698452_08
EN300-18563907
Q937085
BRD-K39462424-050-09-8
[(3S)-3-(4-chlorophenyl)-3-(pyridin-2-yl)propyl]dimethylamine
2-PYRIDINEPROPANAMINE, .GAMMA.-(4-CHLOROPHENYL)-N,N-DIMETHYL-, (.GAMMA.S)-