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Estrone

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Identification
Molecular formula
C18H22O2
CAS number
53-16-7
IUPAC name
(3S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
State
State

Estrone is typically solid at room temperature, existing as a crystalline powder.

Melting point (Celsius)
254.00
Melting point (Kelvin)
527.15
Boiling point (Celsius)
443.60
Boiling point (Kelvin)
716.75
General information
Molecular weight
270.37g/mol
Molar mass
270.3660g/mol
Density
1.2310g/cm3
Appearence

Estrone is a white to off-white crystalline powder. The compound appears in solid form at room temperature and has no distinctive odor. It is relatively stable under standard conditions of temperature and pressure.

Comment on solubility

Solubility Characteristics

The compound (3S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one presents intriguing solubility features. Understanding its solubility profile is crucial for various applications in chemical research and industrial use.

Key Points on Solubility

  • Solvent Interaction: The solubility of this compound is highly dependent on the choice of solvent. Polar solvents like water may offer limited solubility due to the compound's hydrophobic character, while organic solvents such as ethanol or dimethyl sulfoxide (DMSO) may enhance its solubility.
  • Temperature Effects: Generally, increasing the temperature tends to increase the solubility of organic compounds. For this specific compound, higher temperatures might facilitate better solvation and dissolution processes.
  • Biological Relevance: Given its structural complexity and presence of hydroxyl groups, its solubility in biological systems could impact its bioavailability and pharmacokinetics, making it a point of interest in medicinal chemistry.

In summary, while the solubility of (3S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one may vary significantly with the solvent type and temperature, understanding these interactions is crucial for its effective application in scientific fields.

Interesting facts

Interesting Facts about (3S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one

This compound is a fascinating member of a class known as steroids, which are characterized by their unique tetracyclic structure. Its name hints at a complex molecular architecture that is both intriguing and biologically relevant.

Biological Significance

The structure of this compound suggests potential roles in biological systems. Some interesting aspects include:

  • Hormonal Activity: Many steroids serve as hormones in various organisms, influencing a range of biological processes from metabolism to immune response.
  • Pharmacological Potential: The hydroxyl group in its structure may enhance interaction with biological targets, making it a candidate for drug development.
  • Natural Occurrence: Compounds with similar structures are often found in nature, particularly in plant and animal hormones.

Chemical Properties

The intricate arrangement of atoms in this compound grants it some intriguing chemical properties:

  • Chirality: The '3S' notation indicates the stereochemistry at the third carbon, which is crucial for its biological activity.
  • Hydroxyl Functionality: The presence of the hydroxyl group not only affects solubility but also plays a significant role in reactivity.

Applications in Research

This compound's structural complexity makes it a subject of interest in various areas of research:

  • Synthetic Chemistry: Investigating its synthesis can yield insights into the development of more efficient synthetic pathways for related compounds.
  • Biochemical Studies: Understanding how this compound interacts with biological molecules opens doors to biochemistry and drug design.

In summary, (3S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one exemplifies the intricate relationship between structure and function in chemistry and biology. Scientists remain intrigued by the vast potential offered by compounds like this one, where a single molecular change can lead to significant biological effects.

Synonyms
SCHEMBL10301247
AKOS030211141
(3S,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethylperhydrocyclopenta[a]phen anthren-17-one