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Dexamethasone

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Identification
Molecular formula
C22H29ClO5
CAS number
50-02-2
IUPAC name
(3S,5R,15R)-15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one
State
State

At room temperature, dexamethasone is in a solid state, typically taking a crystalline powder form.

Melting point (Celsius)
262.00
Melting point (Kelvin)
535.15
Boiling point (Celsius)
568.00
Boiling point (Kelvin)
841.15
General information
Molecular weight
392.47g/mol
Molar mass
392.4650g/mol
Density
1.3200g/cm3
Appearence

Dexamethasone typically appears as a white to off-white crystalline powder. It is practically odorless and has a strong bitter taste.

Comment on solubility

Solubility of (3S,5R,15R)-15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one

The solubility of (3S,5R,15R)-15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one is an intriguing aspect of its chemical behavior.

Several key factors influence its solubility:

  • Polarity: The presence of hydroxyl and acetyl functional groups can enhance solubility in polar solvents such as water or methanol.
  • Molecular Structure: The complex polycyclic structure may lead to varying solubility in different solvent environments.
  • Temperature: Increased temperature typically increases solubility; thus, warming the solvent may improve dissolution.

In conclusion, while specific data on this compound's solubility may be limited, one can hypothesize that:

  • It will likely exhibit moderate solubility in polar solvents due to functional group interactions.
  • The polycyclic nature could hinder complete solubility, particularly in non-polar environments.

Continued studies are essential to characterize the solubility profile, which plays a crucial role in its practical applications and interactions in various chemical systems.

Interesting facts

Exploring (3S,5R,15R)-15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one

This compound presents a fascinating structure with numerous applications and properties worth exploring. Here are some intriguing aspects:

  • Complex Structure: The compound features a pentacyclic structure, indicating a highly intricate arrangement of carbon atoms. This complexity is characteristic of many natural products, which often serve as inspiration for synthetic chemists.
  • Chiral Centers: The presence of multiple stereocenters (specifically in the 3S, 5R, and 15R configurations) underscores the significance of chirality in organic chemistry, impacting how the molecule interacts with biological systems.
  • Biological Relevance: Compounds with similar structures are often explored for their biological activities. These can include potential uses as pharmaceuticals or natural products with anti-cancer or antimicrobial properties.
  • Functional Groups: The molecule contains several functional groups such as acetyl, chloro, and hydroxy groups. Each plays a crucial role in dictating the reactivity and interaction potential of the compound, making them essential in designing new drugs.
  • Natural Product Chemistry: This compound exemplifies the beauty of nature's chemistry, revealing how complex organic molecules can arise from biological pathways. It highlights the importance of studying natural products for drug discovery.
  • Research Opportunities: Due to its complex structure and interesting properties, there is a wealth of potential research areas focusing on synthesis, characterizations, and pharmacological studies.

In summary, (3S,5R,15R)-15-acetyl-9-chloro-15-hydroxy-2,16-dimethyl-pentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one poses numerous opportunities for discussion and research in the field of chemistry. The combination of its structural intricacies and potential biological applications makes it a captivating subject for scientists and students alike.

Synonyms
(3S,5R,15R)-15-acetyl-9-chloro-15-hydroxy-2,16-dimethylpentacyclo[9.7.0.02,8.03,5.012,16]octadeca-7,9-dien-6-one
SCHEMBL95258
AKOS015896515
AC-6213
NS00003858