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Phorbol

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Identification
Molecular formula
C20H28O6
CAS number
17673-25-5
IUPAC name
(3S,5S,7S,10S,12S,14R,15R,18R)-7,12,18-trihydroxy-10,14-dimethyl-15-(5-oxo-2H-furan-3-yl)-2-oxapentacyclo[9.7.0.01,3.05,10.014,18]octadecan-13-one
State
State

Phorbol is a solid at room temperature.

Melting point (Celsius)
251.00
Melting point (Kelvin)
524.15
Boiling point (Celsius)
257.00
Boiling point (Kelvin)
530.15
General information
Molecular weight
380.44g/mol
Molar mass
380.4640g/mol
Density
1.0857g/cm3
Appearence

Phorbol is a crystalline solid that typically appears as colorless or slightly yellowish crystals. It is a highly complex alcohol and displays a structured and rigid molecular framework.

Comment on solubility

Solubility Characteristics of (3S,5S,7S,10S,12S,14R,15R,18R)-7,12,18-trihydroxy-10,14-dimethyl-15-(5-oxo-2H-furan-3-yl)-2-oxapentacyclo[9.7.0.01,3.05,10.014,18]octadecan-13-one

The solubility of complex organic compounds like (3S,5S,7S,10S,12S,14R,15R,18R)-7,12,18-trihydroxy-10,14-dimethyl-15-(5-oxo-2H-furan-3-yl)-2-oxapentacyclo[9.7.0.01,3.05,10.014,18]octadecan-13-one can be quite nuanced due to their intricate structures. Here are some key aspects to consider:

  • Hydrophilicity vs. Hydrophobicity: The presence of multiple hydroxyl (-OH) groups typically increases hydrophilicity, enhancing solubility in polar solvents such as water. Conversely, hydrophobic regions may decrease solubility.
  • Solvent Interaction: Solubility can greatly vary depending on the solvent environment. For instance, organic solvents like ethanol or methanol may solubilize the compound significantly better than water due to compatibility with its non-polar segments.
  • Temperature Effects: Solubility is often temperature-dependent. Increased temperatures may enhance solubility due to greater molecular interactions in the solvent.
  • pH Sensitivity: If the compound contains acidic or basic functional groups, pH can affect its ionization state, subsequently impacting its solubility in different solvents.

In summary, while predictions regarding solubility can be made based on structural components, the actual solubility of this compound stresses the interplay of multiple factors. It is essential to conduct experimental evaluations to accurately ascertain its solubility in various solvents.

Interesting facts

Interesting Facts about (3S,5S,7S,10S,12S,14R,15R,18R)-7,12,18-trihydroxy-10,14-dimethyl-15-(5-oxo-2H-furan-3-yl)-2-oxapentacyclo[9.7.0.01,3.05,10.014,18]octadecan-13-one

This compound is a fascinating example of complex organic chemistry that highlights the intricate nature of molecular architecture. Its structure represents a rare pentacyclic configuration, which is not only notable for its distinctive geometric composition but also indicates potential biological significance.

Key Highlights:

  • Unique Structure: The compound's pentacyclic arrangement showcases a remarkable interplay of rings, exemplifying structural diversity in organic molecules.
  • Hydroxyl Groups: With three hydroxyl groups (-OH) strategically placed in its structure, this compound may exhibit unique reactivity and solubility properties, which could be beneficial in various chemical processes or biological systems.
  • Furan Derivative: The presence of a 5-oxo-2H-furan-3-yl moiety suggests potential applications in medicinal chemistry, particularly due to the known activity of furan-containing compounds in drug design.
  • Stereochemistry: The numerous stereocenters indicate that stereochemical configuration is crucial in determining the compound's biological activity. This emphasizes the importance of chirality in organic chemistry.
  • Potential Applications: Given its structural complexity, researchers may explore this compound in pharmaceutical applications, particularly as potential leads in drug development targeting various diseases.

It is exciting to consider how a compound with such a multifaceted structure can contribute to our understanding of organic chemistry and its applications. The balance between its intricate design and the potential implications in biological systems makes it a rich area for further exploration in the fields of chemistry and pharmacology.