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Phorbol

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Identification
Molecular formula
C20H28O6
CAS number
17673-25-5
IUPAC name
(3S,5S,8R,10R,13S,14S)-3,5,11,14-tetrahydroxy-10-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde
State
State
Solid at room temperature.

Phorbol is a crystalline substance appearing as a solid under normal conditions.

Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
313.00
Boiling point (Kelvin)
586.15
General information
Molecular weight
380.46g/mol
Molar mass
380.4570g/mol
Density
1.2600g/cm3
Appearence
Phorbol is a crystalline solid.

It typically appears as colorless to white crystals when purified.

Comment on solubility

Solubility Overview

The compound (3S,5S,8R,10R,13S,14S)-3,5,11,14-tetrahydroxy-10-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde presents intriguing complexities concerning its solubility in various solvents.

Key Considerations for Solubility:

  • Hydroxyl Groups: The presence of multiple hydroxyl (-OH) groups suggests that the compound could exhibit higher solubility in polar solvents, such as water or methanol, due to hydrogen bonding interactions.
  • Hydrophobic Regions: Conversely, the inclusion of non-polar cycloalkane and aromatic structures may render the compound less soluble in polar solvents and more soluble in non-polar organic solvents like hexane or toluene.
  • pH Sensitivity: The solubility may also vary depending on the pH of the medium due to potential changes in ionization states of the hydroxyl groups. This can lead to altered solubility profiles in different environments.
  • Concentration Dependency: At higher concentrations, this compound may exhibit non-ideal behavior in solution, which can further complicate the solubility assessment.

Conclusion

In general, the solubility of this compound is influenced by an interplay of its functional groups and structural characteristics. As a result, it is essential to evaluate solubility experimentally under various conditions to obtain comprehensive data on its behavior in different solvents.

Interesting facts

Interesting Facts about (3S,5S,8R,10R,13S,14S)-3,5,11,14-tetrahydroxy-10-methyl-17-(5-oxo-2H-furan-3-yl)-2,3,4,6,7,8,9,11,12,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-13-carbaldehyde

This complex organic compound presents a fascinating case study due to its intricate structure and potential applications. Here are some intriguing aspects:

  • Stereo-specificity: The compound features a series of chiral centers which contribute to its stereochemistry. The labeling of specific stereocenters (like 3S and 5S) indicates that the orientation of atoms in space is crucial for its biological activity and reactivity.
  • Multifunctionality: With multiple hydroxy groups and an aldehyde functional group, this compound is highly functionalized. This allows it to participate in various chemical reactions, possibly exhibiting both reducing and oxidizing properties.
  • Natural Product Inspiration: Compounds with similar complex structures are often found in natural products, suggesting potential pharmacological benefits. They could serve as lead compounds in drug discovery, particularly in fields like oncology or anti-inflammatory therapies.
  • Structure Activity Relationship (SAR): Researchers are keen on understanding the SAR of compounds like this one because slight alterations in structure can lead to significant changes in biological activity.
  • Research Applications: Due to its elaborate structure, this compound could be of interest in synthetic organic chemistry for the development of new synthetic pathways or methodologies aimed at similar complex architectures.

In summarizing this compound, a notable quote comes to mind: "Chemistry is the essence of life, and the beauty of its complexity is what drives scientific inquiry." As researchers delve into such intricate molecules, the potential for discovery is endless.

Synonyms
DTXSID90987199
3,5,11,14-Tetrahydroxy-18-oxocard-20(22)-enolide