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Cucurbitacin E

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Identification
Molecular formula
C32H42O8
CAS number
18444-66-1
IUPAC name
[(3S,8R,10S,13R,14R,17R)-3,8,14-trihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,6,7,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-10-yl]methyl acetate
State
State

At room temperature, Cucurbitacin E is typically found as a solid. It is often extracted in laboratories for its biological properties, and due to its crystalline nature, it should be handled with care in a dry, well-controlled environment to prevent degradation.

Melting point (Celsius)
182.00
Melting point (Kelvin)
455.20
Boiling point (Celsius)
624.50
Boiling point (Kelvin)
897.70
General information
Molecular weight
578.66g/mol
Molar mass
578.6630g/mol
Density
1.2125g/cm3
Appearence

Cucurbitacin E is a naturally occurring compound that generally appears as a colorless to lightly yellow crystalline solid. It is derived from plants, often found in the family Cucurbitaceae, which includes gourds, melons, and cucumbers.

Comment on solubility

Solubility of the Compound

The solubility of the compound [(3S,8R,10S,13R,14R,17R)-3,8,14-trihydroxy-13-methyl-17-(6-oxopyran-3-yl)-2,3,6,7,9,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-10-yl]methyl acetate can be described as follows:

  • Polarity: The presence of multiple hydroxyl groups (-OH) suggests significant polar character, which typically enhances solubility in polar solvents such as water.
  • Hydrophobic Regions: Given the large hydrophobic hydrocarbon structure, one might expect limited solubility in highly polar solvents, indicating a potential preference for organic solvents.
  • Hydrogen Bonding: The hydroxyl groups can form hydrogen bonds with solvents, potentially increasing solubility in alcohols or other polar solvents.
  • Complexation: The presence of the oxopyran moiety might also influence the solubility through complexation with various ions or organic solutes.

In summary, while the compound exhibits characteristics suggesting good solubility in certain polar solvents, the extensive hydrophobic region could hinder its overall solubility in water. Considering both aspects, its solubility profile is likely to vary significantly based on the solvent system used. As with many organic compounds, it is advisable to perform empirical checks under controlled conditions to determine the precise solubility behavior.

Interesting facts

Interesting Facts about the Compound

This fascinating compound, a kind of steroid derivative, has garnered attention in various fields of chemistry and medicine. Here are some compelling aspects that highlight its significance:

  • Structural Complexity: The compound features a unique stereochemistry that plays a crucial role in its biological activity. The multiple chiral centers contribute to its ability to interact with biological systems in a highly specific manner.
  • Biological Implications: As a steroid derivative, it is of particular interest in the study of hormones. Compounds like these can mimic the action of natural hormones in the body, which is essential for drug design and development.
  • Natural Occurrence: Many steroid derivatives can be found in plants and animals. Understanding the biosynthesis of such complex compounds can provide insights into natural metabolic pathways and their applications in biotechnology.
  • Pharmaceutical Applications: Research into compounds with similar structures has led to the development of therapeutics for various conditions, including anti-inflammatory drugs and cancer treatments. The exploration of this compound may uncover new pathways for drug discovery.
  • Ongoing Research: Scientists continue to study the interactions and effects of such compounds at the molecular level. Innovations in analytical techniques, such as spectroscopy and chromatography, facilitate this research, shedding light on how these compounds can be utilized in medicine.

In conclusion, this compound encapsulates the beauty and complexity of organic chemistry. The intersection of structure, function, and application makes it a fascinating subject for ongoing research and discovery in the field.