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Estradiol

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Identification
Molecular formula
C18H24O2
CAS number
50-28-2
IUPAC name
(3S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
State
State

At room temperature, estradiol is in a solid crystalline state.

Melting point (Celsius)
173.00
Melting point (Kelvin)
446.15
Boiling point (Celsius)
398.00
Boiling point (Kelvin)
671.15
General information
Molecular weight
272.38g/mol
Molar mass
272.3820g/mol
Density
1.1710g/cm3
Appearence

Estradiol appears as a white to creamy white, crystalline powder that is odorless and appears solid at room temperature.

Comment on solubility

Solubility Characteristics

The solubility of the compound (3S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol can be considered through various factors that influence its dissolution behavior in solvents.

Factors Influencing Solubility

Key aspects to consider include:

  • Polarity: The presence of hydroxyl groups (-OH) suggests that the compound may have some polar characteristics, which could enhance its solubility in polar solvents, such as water.
  • Molecular Size: The complex steric structure and size of the molecule may hinder its ability to dissolve readily in solvents. Larger, bulky molecules tend to have lower solubility in comparison to smaller compounds.
  • Intermolecular Forces: The interactions between the compound's molecules and those of the solvent play a crucial role. Strong hydrogen bonding capabilities from hydroxyl groups may promote solubility in solvents that can engage in such interactions.

General Solubility Observations

In a practical sense, the solubility of this compound can be summarized as follows:

  • It is likely to be soluble in alcohols and ethers due to favorable hydrogen bonding.
  • It may exhibit limited solubility in water, especially if the solvent's polarity does not match the compound's structural characteristics.
  • In non-polar solvents, such as hexane, solubility could be significantly lower due to the lack of effective interactions.

Overall, understanding the solubility of this compound is essential and requires careful consideration of its chemical structure and the properties of potential solvents.

Interesting facts

Interesting Facts about (3S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol

This complex compound, often referenced in the context of natural products and biochemistry, belongs to the category of steroid-like molecules. Steroids are renowned for their vast array of biological functions and therapeutic applications. Here are a few intriguing facts about this compound:

  • Stereochemistry Matters: The carefully designated stereochemical positions (designated by S and R) indicate the spatial arrangement of atoms, crucial for the compound's biological activity.
  • Biological Relevance: Compounds similar to this structure are often involved in hormone production and regulation within the human body, highlighting their importance in physiology.
  • Natural Origins: This compound's structure is reminiscent of naturally occurring steroids, which are often derived from plant and animal sources. Understanding its synthesis can lead to potential medicinal applications.
  • Research Potential: As scientists continue to explore the biological functions of complex sterol structures, this compound may hold therapeutic potential, particularly in areas such as oncology and metabolic disorders.

In the realm of organic chemistry and pharmacology, compounds like this are often referred to as bioactive molecules due to their ability to produce significant effects on living organisms. As a future perspective, ongoing research into similar compounds might unlock new avenues for drug development and enhance our understanding of biological mechanisms.

Quote to Ponder: “In every drop of ink flows the potential for life-altering discovery.” Thus, delving deeply into the chemistry of compounds like this could indeed spur groundbreaking advancements in medicine.

Synonyms
Androstenediol
Hermaphrodiol
5-Androstenediol
521-17-5
Androst-5-enediol
Neumune
Androst-5-ene-3beta,17beta-diol
Androstenediol [JAN]
3beta,17beta-Dihydroxyandrost-5-ene
delta(sup 5)-Androstenediol
5-andendiol
HE2100
Androst-5-enediol (VAN)
5-AED
(3beta,17beta)-androst-5-ene-3,17-diol
3beta,17beta-Dihydroxy-5-androstene
Tetrabol
EINECS 208-306-8
95PS51EMXY
NSC 12163
Tetrabol (TN)
CHEBI:2710
Androstenediol (JAN)
DTXSID9022609
5-Androstene-3beta,17beta-diol
(3-beta,17-beta)-Androst-5-ene-3,17-diol
Androst-5-ene-3,17-diol, (3beta,17beta)-
delta(sup 5)-Androstene-3-beta,17-beta-diol
NSC-12163
(3S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
5 Androstene 3,17 diol
ANDROSTENEDIOL [MI]
HE-2100
ANDROSTENEDIOL [MART.]
ANDROSTENEDIOL, (-)-
DTXCID002609
ANDROSTENEDIOL [WHO-DD]
5-Androstene-3.beta.,17.beta.-diol
5-ANDROSTENE-3.BETA.O,17.BETA.-DIOL
(3.beta.,17.beta.)-Androst-5-ene-3,17-diol
ANDROSTENEDIOL (MART.)
Delta 5-Androstenediol
5-Androstene-3,17-diol
5-Androstene-3beta-17beta-Diol
Delta 5 Androstenediol
Androst-5-ene-3 beta,17 beta-diol
Androst 5 ene 3,17 diol
delta 5-Androstene-3 beta,17 beta-diol
NSC12163
5 Androstene 3beta 17beta Diol
(3S,8R,9S,10R,13S,14S,17S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta(a)phenanthrene-3,17-diol
Androst 5 ene 3 beta,17 beta Diol
delta 5 Androstene 3 beta,17 beta Diol
DTXSID901346365
5-ANDROSTENE-3BETAO,17BETA-DIOL
Androst-5-ene-3,17-diol, (3beta,17beta)-(9CI)
28652-91-7
Adiol
androst-5-en-3beta,17beta-diol
CHEMBL440283
NCGC00167494-01
(3alpha,8alpha,17beta)-androst-5-ene-3,17-diol
3Beta,17Beta-Androst-5-enediol
CAS-521-17-5
UNII-95PS51EMXY
3b,17b-Androst-5-enediol (1.0mg/ml in Acetonitrile)
ANDROST-5-ENE-3-beta,17-beta-DIOL
Androst-5-ene-3,17-diol, (3b,17b)-
beta-AED
b,17b-diol
delta5-Androstenediol
delta-5-Androstenediol
BIDD:PXR0074
SCHEMBL27485
Androst-5-ene-3b,17b-diol
Androst-5-ene-3,17-diol #
Tox21_112495
BDBM50223237
LMST02020005
3beta,17beta-dihydroxy-androst-5-en
AKOS015955537
Tox21_112495_1
DB01524
NCGC00263558-01
AC-12166
Androst-5-ene, 3beta,17beta-dihydroxy-
NS00000086
13-Iso-androst-5-en-3.beta.,17.beta.-diol
C04295
D00179
Q2817108
W-105849
017E86D6-684F-4DB1-90E0-55C1467FF85B
(3S,8R,10R,13S,17S)-10,13-Dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthrene-3,17-diol
B81
Hermaphrodiol; (3S,8R,9S,10R,13S,14S,17S)-10,13-Dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanth rene-3,17-diol