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Menthol

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Identification
Molecular formula
C10H20O
CAS number
89-78-1
IUPAC name
4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol
State
State

Menthol is mostly encountered as a solid crystalline substance at room temperature. However, its solid form can easily melt into a liquid due to its relatively low melting point just above room temperature.

Melting point (Celsius)
42.00
Melting point (Kelvin)
315.15
Boiling point (Celsius)
212.00
Boiling point (Kelvin)
485.15
General information
Molecular weight
156.27g/mol
Molar mass
156.2690g/mol
Density
0.8906g/cm3
Appearence

Menthol is a colorless or white crystalline substance when in its solid form. It often appears in the form of flakes, granules, or as a crystalline powder. Menthol is known for its distinctive peppermint flavor and aroma, which is strong and characteristic.

Comment on solubility

Solubility of 4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol

Understanding the solubility of 4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol can provide valuable insights into its potential applications and behaviors in various environments. Here are some key points to consider:

  • Polarity: The presence of a hydroxyl group (-OH) typically increases solubility in polar solvents, particularly water.
  • Hydrophobic and Hydrophilic Interactions: The cyclohexanol structure may impart both hydrophobic (non-polar) and hydrophilic (polar) characteristics, which can affect solubility in different types of solvents.
  • Temperature Influence: Solubility might increase with temperature, especially for organic compounds, leading to greater dissolution in solvents as kinetic energy increases.
  • Solvent Type: Solubility is often higher in organic solvents such as ethanol or acetone than in water, due to compatibility with the compound's non-polar regions.

In conclusion, while 4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol may exhibit reasonable solubility in certain solvents, understanding the balance between its hydrophobic and hydrophilic parts is crucial. As noted, "solubility is the key to reactivity," and this principle applies here as well.

Interesting facts

Interesting Facts about 4-(1-Hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol

4-(1-Hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol is an intriguing compound with a unique structure, making it a subject of interest in both organic chemistry and the field of natural product synthesis. Here are some captivating insights about this compound:

  • Structural Complexity: The presence of both hydroxy and alkyl groups in its structure contributes to its interesting chemical properties. This complexity can lead to diverse reactivity patterns in various chemical reactions.
  • Chirality: The compound is chiral, meaning it can exist in multiple forms (enantiomers). This property is significant in pharmacology, as different enantiomers can exhibit different biological activities.
  • Potential Applications: Compounds with similar structures are often studied for their potential applications in fragrances, flavors, or as intermediates in pharmaceutical synthesis. This compound could potentially serve as a building block for more complex molecules in drug development.
  • Research Significance: As a derivative of cyclohexanol, it can be studied for its role in understanding the conformational behavior of cyclic alcohols. This knowledge is crucial for predicting the behavior of similar compounds in various environments.
  • Natural Occurrence: Compounds with related structures often occur in nature, and their study can lead to the identification of new natural products with therapeutic properties. Research into this compound may reveal connections to biologically active substances occurring in different plants or microorganisms.

In the world of organic compounds, 4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol stands as a testament to the intricate relationships between structure and function, sparking curiosity among chemists and students alike. Its unique features serve as an exciting point of exploration in synthetic and medicinal chemistry.

Synonyms
TERPIN
p-Menthane-1,8-diol
trans-Terpin
80-53-5
565-48-0
cis-p-Menthan-1,8-diol
1,8-Terpin
4-(2-hydroxypropan-2-yl)-1-methylcyclohexan-1-ol
565-50-4
Terpin, trans-
cis-1,8-p-Menthanediol
trans-1,8-Terpin
trans-p-Menthan-1,8-diol
Terpene
NSC 403856
cis-4-Hydroxy-alpha,alpha,4-trimethylcyclohexanemethanol
Terpin trans-form [MI]
trans-1,8-p-Menthanediol
trans-p-Menthane-1,8-diol
(Z)-terpin
Terpinol
NSC-403856
4HW1S44T5G
MPF495B08R
Cyclohexanemethanol, 4-hydroxy-.alpha.,.alpha.,4-trimethyl-
DTXSID7023643
4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol
NCGC00159414-02
4-p-Menthan-1,8-diol
Dipenteneglycol
Terpin (VAN)
Terpin [BAN]
UNII-4HW1S44T5G
UNII-MPF495B08R
Terpinhydrat
trans_terpin
EINECS 201-288-2
EINECS 209-279-5
p-Mentha-1,8-diol
TERPIN [WHO-DD]
TERPIN [MI]
cis-p-Menthane-1,8-diol
EC 201-288-2
SCHEMBL19192
4-Hydroxy-alpha,alpha,4-trimethylcyclohexanemethanol
DTXCID903643
SCHEMBL5377815
SCHEMBL9536260
CHEMBL1414114
CHEMBL1513871
CHEMBL1651998
Cyclohexanemethanol, 4-hydroxy-alpha,alpha,4-trimethyl-
CHEBI:134806
CHEBI:179539
DTXSID401031800
DTXSID501031803
Pharmakon1600-01506188
Cyclohexanemethanol, 4-hydroxy-alpha,alpha,4-trimethyl-, trans-
HY-N4324
Tox21_111646
BBL034665
NSC403856
NSC760418
STL356461
AKOS022099020
AKOS024348939
AKOS037514988
CAS-80-53-5
Cyclohexanemethanol,.alpha.,4-trimethyl-
NCGC00159414-01
NCGC00159414-03
NCGC00159414-04
NCGC00159414-05
NCGC00159414-06
NCGC00166136-01
AS-83272
DA-48919
NCI60_003817
PD132153
SID124892172
trans-Terpin, analytical standard, for GC
CS-0032749
NS00004546
NS00079759
T2344
G83071
SBI-0653368.0001
AB01563167_01
4-(1-Hydroxy-1-methylethyl)-1-methylcyclohexanol
cis-4-Hydroxy-|A,|A,4-trimethylcyclohexanemethanol
TERPIN MONOHYDRATE IMPURITY D [EP IMPURITY]
4-(1-Hydroxy-1-methylethyl)-1-methylcyclohexanol #
BRD-K93396439-002-01-2
Q27259605
Q27284154
(1R,4R)-4-(2-HYDROXYPROPAN-2-YL)-1-METHYLCYCLOHEXAN-1-OL
CYCLOHEXANEMETHANOL, 4-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-, CIS-
CYCLOHEXANEMETHANOL, 4-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-, TRANS-