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Terbinafine Hydrochloride Hydrate

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Identification
Molecular formula
C16H27NO2·HCl·H2O
CAS number
78628-80-5
IUPAC name
4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol;hydrate
State
State

At room temperature, it exists as a crystalline solid. It is often provided in the form of tablets or as a topical form for pharmaceutical applications.

Melting point (Celsius)
204.00
Melting point (Kelvin)
477.00
Boiling point (Celsius)
162.80
Boiling point (Kelvin)
435.90
General information
Molecular weight
343.90g/mol
Molar mass
343.8990g/mol
Density
1.5000g/cm3
Appearence

The compound is typically a white to off-white crystalline powder. It is stable under normal temperatures and pressures, and it is hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol;hydrate

The solubility of 4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol;hydrate can be characterized by several key aspects:

  • Hydration Effects: Being a hydrate, the presence of water molecules in its structure can significantly influence its solubility. Hydration usually enhances solubility in polar solvents due to hydrogen bonding.
  • Polarity: This compound appears to possess multiple functional groups that may enhance polarity, potentially increasing its solubility in polar solvents like water.
  • Structure Influence: The cyclohexanol moiety contributes to hydrophobic interactions; hence, solubility may be lower in non-polar solvents.
  • Solvent Interaction: This compound may exhibit differing solubility behavior in various solvents. For example:
    • Highly soluble in water
    • Moderately soluble in ethanol
    • Poorly soluble in hexane

In conclusion, the solubility of this compound will primarily depend on its interaction with the solvent and the balance between hydrophilic and hydrophobic characteristics. As a general rule, compounds with more polar functional groups tend to be more soluble in polar solvents.

Interesting facts

Interesting Facts about 4-(1-Hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol; Hydrate

4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol; hydrate is a fascinating compound that provides insights into both organic chemistry and its applications in various fields. Here are some intriguing facts:

  • Hydration Significance: The presence of water molecules in its hydrate form implies a stable structure that can play a critical role in its solubility and reactivity. Hydration can enhance the stability of compounds, affecting their properties and utility in chemical reactions.
  • Stereochemistry: This molecule contains multiple chiral centers, which can lead to the existence of various stereoisomers. Understanding the implications of chirality is essential in fields like pharmaceuticals, as each isomer can have different biological activities.
  • Potential Applications: Given its structure, this compound might find uses in industries ranging from cosmetics to pharmaceuticals. Specifically, it could serve as an intermediate in the synthesis of more complex organic molecules or even act as a potential active ingredient in formulations.
  • Natural Product Chemistry: Compounds with similar structures are often found in nature. Exploring their natural occurrences can provide insights into biological pathways and the development of new drugs.
  • Research and Innovation: The study of such compounds is essential for the advancement of chemical science. By investigating their properties and synthesis, chemists can contribute to innovations in materials science, help in drug design, and improve existing chemical processes.

As we continue to explore the myriad of chemical compounds like 4-(1-hydroxy-1-methyl-ethyl)-1-methyl-cyclohexanol; hydrate, we uncover new possibilities that can lead to developments in health, technology, and sustainability. By understanding the core principles underlying their behavior, chemists can pave the way for future innovations.

Synonyms
TERPIN HYDRATE
Terpin monohydrate
p-Menthane-1,8-diol monohydrate
Terpin cis-form hydrate
Terpinol hydrate
cis-Terpin hydrate
terpinene hydrate
Terpinol
Cyclohexanemethanol, 4-hydroxy-alpha,alpha,4-trimethyl-, hydrate (1:1), cis-
cis-p-methane-1,8-diol monohydrate
NSC-760418
S3V868548T
Cyclohexanemethanol, 4-hydroxy-alpha,alpha,4-trimethyl-, monohydrate
TERPIN HYDRATE [VANDF]
TERPIN HYDRATE [MART.]
TERPIN HYDRATE [USP-RS]
TERPIN HYDRATE [WHO-DD]
p-Menthane-1,8-diol, monohydrate
TERPIN CIS-FORM HYDRATE [MI]
TERPIN HYDRATE [USP MONOGRAPH]
TERPIN MONOHYDRATE [EP MONOGRAPH]
TERPIN HYDRATE (MART.)
TERPIN HYDRATE (USP-RS)
(1S,4S)-4-(2-HYDROXYPROPAN-2-YL)-1-METHYLCYCLOHEXAN-1-OL HYDRATE
TERPIN HYDRATE (USP MONOGRAPH)
CYCLOHEXANEMETHANOL, 4-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-, HYDRATE (1:1), CIS-
CYCLOHEXANEMETHANOL, 4-HYDROXY-.ALPHA.,.ALPHA.,4-TRIMETHYL-, MONOHYDRATE
TERPIN MONOHYDRATE (EP MONOGRAPH)
Terpocodein
Cheracol
DTXSID201019020
2451-01-6
Terpin (hydrate)
Cis-p-menthane-1,8-diol monohydrate
Terpin monohydrate;cis-Terpin hydrate
Terpin hydrate (USP)
Terpin hydrate [USP]
rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate
terpine hydrate
MFCD00167312
TERPINHYDRATE
AI3-01762
SCHEMBL29867
Terpin (hydrate) (Standard)
SCHEMBL2487459
CHEMBL2105614
UNII-S3V868548T
HY-B1063R
4-(2-hydroxypropan-2-yl)-1-methylcyclohexan-1-ol hydrate
4-(2-hydroxypropan-2-yl)-1-methylcyclohexan-1-ol,hydrate
4-(2-hydroxypropan-2-yl)-1-methylcyclohexan-1-ol;hydrate
DTXSID00947401
JGKJMBOJWVAMIJ-UHFFFAOYSA-N
HMS3264B12
HY-B1063
s4577
AKOS016013500
AKOS024288517
CCG-213672
CCG-266507
CS-4619
DB13163
KS-1430
NSC 760418
cis-1 pound not8-p-Menthanediol monohydrate
D06081
D92597
EN300-8109909
SR-01000944230
Q2273017
SR-01000944230-1
4-(2-Hydroxypropan-2-yl)-1-methylcyclohexan-1-ol--water (1/1)
Terpin hydrate, United States Pharmacopeia (USP) Reference Standard
CIS-4-HYDROXY-ALPHA,ALPHA,4-TRIMETHYLCYCLOHEXANEMETHANOL MONOHYDRATE
Cyclohexanemethanol, 4-hydroxy-|A,|A,4-trimethyl-, hydrate (1:1), cis-