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Salbutamol Hydrochloride

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Identification
Molecular formula
C13H21NO3⋅HCl
CAS number
51022-70-9
IUPAC name
4-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol;hydrochloride
State
State

At room temperature, Salbutamol Hydrochloride is typically in a solid state, specifically as a crystalline powder. It is often used in this form for pharmaceutical applications, especially in formulations for asthma and other respiratory conditions.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.00
Boiling point (Celsius)
196.00
Boiling point (Kelvin)
469.00
General information
Molecular weight
239.72g/mol
Molar mass
240.3110g/mol
Density
1.3000g/cm3
Appearence

Salbutamol Hydrochloride usually appears as a white or slightly yellowish crystalline powder. It is odourless or practically odourless.

Comment on solubility

Solubility of 4-[1-Hydroxy-2-[(1-Methyl-2-Phenoxy-Ethyl)Amino]Propyl]Phenol; Hydrochloride

The solubility of the compound 4-[1-hydroxy-2-[(1-methyl-2-phenoxy-ethyl)amino]propyl]phenol; hydrochloride is influenced by its structural characteristics and the presence of functional groups.

Generally, the solubility can be understood by considering the following key points:

  • Hydrochloride Form: As a hydrochloride salt, this compound is likely to have increased solubility in water compared to its free base form. This is due to the ionization of the amine group, which facilitates solvation.
  • Polarity: The presence of multiple hydroxyl groups can enhance hydrogen bonding with water, promoting solubility.
  • Phenoxy Group: The phenoxy moiety could introduce hydrophobic characteristics, potentially reducing water solubility to some extent.

In summary, while the presence of the hydrochloride form and the hydroxyl groups suggest a relatively high solubility in aqueous environments, it is essential to conduct empirical measurements to determine the exact solubility characteristics under various conditions. As with many compounds, solubility may be influenced by factors such as temperature and pH.

Interesting facts

Interesting Facts About 4-[1-Hydroxy-2-[(1-Methyl-2-Phenoxy-Ethyl)Amino]Propyl]Phenol Hydrochloride

This compound, often referred to in the field of medicinal chemistry, showcases unique structural characteristics that contribute to its pharmaceutical applications. Here are some fascinating insights:

  • Structure and Function: This compound features a complex chain with both a phenolic portion and an amine moiety, which play a critical role in its biological activity. The presence of the –OH group enhances its solubility and ability to interact with biological targets.
  • Pharmaceutical Relevance: It has been studied for its potential in therapeutic applications, particularly in the treatment of certain conditions such as cardiovascular diseases. Its dual functionality allows it to act both as a medicinal agent and an intermediate in synthesizing more potent derivatives.
  • Mechanism of Action: The compound is known to influence certain neurotransmitter pathways. It is believed to modulate the activity of specific receptors, offering insight into how drug design can target particular mechanisms in the body.
  • Research Studies: Various studies have investigated the pharmacokinetics and bioavailability of this compound, shedding light on how modifications to its structure can enhance therapeutic efficacy.
  • Safety Profile: As with many compounds used in medicine, it's crucial to study its safety profile. Ongoing research includes examining any potential side effects and interactions with other medications.

In summary, 4-[1-Hydroxy-2-[(1-Methyl-2-Phenoxy-Ethyl)Amino]Propyl]Phenol Hydrochloride exemplifies the intricate relationship between chemical structure and biological function, making it a subject of continued interest in the scientific community.

Synonyms
Isoxsuprine hydrochloride
579-56-6
Isoxsuprine HCl
vadosilan
Duviculine
Navilox
DTXSID1045328
DTXCID9025328
NSC-757067
1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1 hydrochloride
p-Hydroxy-alpha-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)benzyl alcohol hydrochloride
Norephedrine, p-hydroxy-N-(1-methyl-2-phenoxyethyl)-, hydrochloride
ISOXSUPRINE HYDROCHLORIDE (MART.)
ISOXSUPRINE HYDROCHLORIDE (USP-RS)
ISOXSUPRINE HYDROCHLORIDE (EP MONOGRAPH)
ISOXSUPRINE HYDROCHLORIDE (USP MONOGRAPH)
Hydrochloride, Isoxsuprine
Benzenemethanol, 4-hydroxy-alpha-(1-((1-methyl-2-phenoxyethyl)amino)ethyl)-, hydrochloride
1-(P-HYDROXYPHENYL)-2-(1-METHYL-2-PHENOXYETHYLAMINO)-1-PROPANOL, HYDROCHLORIDE
2-(3-PHENOXY-2-PROPYLAMINO)-1-(P-HYDROXYPHENYL)-1-PROPANOL, HYDROCHLORIDE
(1RS,2SR)-1-(4-Hydroxyphenyl)-2-(((2SR)-1-phenoxypropan-2-yl)amino)propan-1-ol monohydrochloride
209-443-6
BENZYL ALCOHOL, P-HYDROXY-ALPHA-(1-((1-METHYL-2-PHENOXYETHYL)AMINO)ETHYL-, HYDROCHLORIDE
(+-)-(alphar*)-p-hydroxy-alpha-((1s*)-1-(((1s*)-1-methyl-2-phenoxyethyl)amino)ethyl)benyl alcohol hydrochloride
Duvadilan
Benzenemethanol,4-hydroxy-a-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-, hydrochloride
Dilavase
4-(1-Hydroxy-2-((1-phenoxypropan-2-yl)amino)propyl)phenol hydrochloride
MLS000028704
579-56-6 (HCl)
SMR000058729
4-{1-hydroxy-2-[(1-phenoxypropan-2-yl)amino]propyl}phenol hydrochloride
Duvadilan (TN)
Prestwick_500
Opera_ID_1429
NCGC00016512-01
4-[1-hydroxy-2-(1-phenoxypropan-2-ylamino)propyl]phenol;hydrochloride
CAS-579-56-6
MLS001148084
MLS002695887
SCHEMBL124661
CHEMBL559180
MSK1315A
CHEBI:31735
HY-B1270R
QVPSGVSNYPRFAS-UHFFFAOYSA-N
HMS1568M17
HY-B1270
Isoxsuprine hydrochloride (Standard)
Tox21_110467
s5669
AKOS030254697
Isoxsuprine hydrochloride (JP18/USP)
Tox21_110467_1
CCG-220068
CS-8212
NC00514
NCGC00018295-05
NCGC00094704-01
NCGC00094704-02
NCGC00094704-03
AS-76145
DB-053134
NS00080107
Isoxsuprine hydrochloride, analytical standard
D01748
D81952
EN300-18530854
SR-01000000272
SR-01000000272-2
erythro-Isoxsuprine hydrochloride, VETRANAL(TM), analytical standard
4-(1-Hydroxy-2-((1-phenoxypropan-2-yl)amino)propyl)phenolhydrochloride
Isoxsuprine hydrochloride, European Pharmacopoeia (EP) Reference Standard
Isoxsuprine hydrochloride, United States Pharmacopeia (USP) Reference Standard
(+/-)-(alphaR*)-P-HYDROXY-alpha-((1S*)-1-(((1S*)-1-METHYL-2-PHENOXYETHYL)AMINO)ETHYL)BENYL ALCOHOL HYDROCHLORIDE
34331-89-0