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Isoprenaline hydrochloride

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Identification
Molecular formula
C11H18ClNO3
CAS number
51-31-0
IUPAC name
4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol;hydrochloride
State
State

At room temperature, Isoprenaline hydrochloride is generally found in a solid state.

Melting point (Celsius)
155.00
Melting point (Kelvin)
428.15
Boiling point (Celsius)
210.00
Boiling point (Kelvin)
483.15
General information
Molecular weight
247.72g/mol
Molar mass
247.7230g/mol
Density
1.3000g/cm3
Appearence

The compound typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol; hydrochloride

The compound 4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol; hydrochloride, with the chemical formula C11H18ClNO3, displays interesting solubility characteristics that warrant attention.

Key Solubility Insights:

  • Hydrochloride Form: The presence of the chloride ion often enhances solubility in water. This is due to the strong ionic interactions that facilitate dissociation.
  • Polar Functional Groups: The molecule contains hydroxyl (-OH) and amine (-NH) groups, which can form hydrogen bonds with water molecules, increasing overall solubility.
  • Isopropylamine Moiety: While isopropyl components are generally hydrophobic, the isopropylamino structure may provide a balance between hydrophobic and hydrophilic interactions, affecting solubility in organic solvents.
  • Temperature Dependency: Like many compounds, solubility may vary with temperature, often increasing with higher temperatures due to increased kinetic energy.

Overall, it can generally be anticipated that this compound will demonstrate good solubility in water and various polar solvents, making it suitable for applications where aqueous solutions are required. However, further empirical testing is recommended to quantify its solubility in different media, as this can significantly impact its behavior in practical scenarios.

Interesting facts

Interesting Facts about 4-[1-Hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol Hydrochloride

This compound, commonly known as a hydrochloride salt form, plays a significant role in medicinal chemistry due to its structural attributes and biological activities. It is primarily recognized for its potential applications in the pharmaceutical industry. Here are some fascinating points about this compound:

  • Pharmacological Relevance: The compound features an isopropylamino group, which lends to its prominence in drug design as it can enhance receptor binding and biological activity.
  • Synthesis: The synthesis process often involves complex reactions, which are crucial for obtaining compounds with specific characteristics necessary for therapeutic effects.
  • Structure-Activity Relationship (SAR): Understanding how modifications to the compound's structure can impact its biological effects is fundamental, making it a subject of various research studies.
  • Research Applications: Due to its functional groups, this compound has shown potential in studies related to neurological disorders and cardiovascular health, indicating its versatility.
  • Hydrochloride Form: The hydrochloride version often offers improved stability and solubility, which are essential for drug formulation and efficacy.

As a compound that bridges organic chemistry and pharmacology, 4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol hydrochloride exemplifies how intricate molecular design can lead to significant therapeutic advancements. As Dr. Jane Goodwin once said, "The magic of chemistry lies in the possibility of transforming simple molecules into powerful medicines."

The study of such compounds not only inspires future innovations in drug development but also enhances our understanding of molecular interactions within biological systems.

Synonyms
Isoprenaline hydrochloride
51-30-9
ISOPROTERENOL HYDROCHLORIDE
Isoprenaline HCl
Isuprel
Euspiran
Aerolone
Aerotrol
Isoproterenol HCl
Vapo-Iso
Asthpul
DL-Isoprenaline hydrochloride
Isomenyl
Norisodrine Aerotrol
Izadrin
DL-Isoproterenol hydrochloride
Isuprel hydrochloride
Isopropylarterenol hydrochloride
Norisodrine hydrochloride
dl-Isadrine hydrochloride
Isoprenaline chloride
NSC 37745
Mistarel
Suscardia
Isovon
Isoproterenol monohydrochloride
NSC 89747
(+-)-Isoprenaline hydrochloride
(+-)-Isoproterenol hydrochloride
NCI-C55630
Isoprenaline (hydrochloride)
949-36-0
Isopropylnorepinephrine-hydrochloride
CCRIS 5921
DL-Isopropylnorepinephrine hydrochloride
(+-)-Isopropylnoradrenaline hydrochloride
EINECS 200-089-8
NSC-37745
NSC-89747
UNII-DIA2A74855
Isoprenaline hydrochloride, dl-
DTXSID6025486
AI3-52675
DIA2A74855
l-Isoprenaline hydrochloride
(+/-)-Isoproterenol hydrochloride
MFCD00012603
4-(1-hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol hydrochloride
1,2-Benzenediol, 4-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, hydrochloride
Benzenemethanol, 3,4-dihydroxy-alpha-(((1-methylethyl)amino)methyl)-, hydrochloride, (+/-)-
DTXCID105486
Isoproterenol hydrochloride (USP)
Isoproterenol hydrochloride [USP]
alpha-(Isopropylaminomethyl)-3,4-dihydroxybenzyl alcohol hydrochloride
3,4-Dihydroxy-alpha-((isopropylamino)methyl)benzyl alcohol hydrochloride
4-{1-hydroxy-2-[(propan-2-yl)amino]ethyl}benzene-1,2-diol hydrochloride
NSC37745
NSC89747
DL-Isopropylnoradrenaline hydrochloride
1-(3',4'-Dihydroxyphenyl)-2-isopropylaminoethanol hydrochloride
4-[1-hydroxy-2-(propan-2-ylamino)ethyl]benzene-1,2-diol;hydrochloride
Benzyl alcohol, 3,4-dihydroxy-alpha-((isopropylamino)methyl)-, hydrochloride
DUO-MEDIHALER COMPONENT ISOPROTERENOL HYDROCHLORIDE
dl-Isoprenaline hydrochloride (JAN)
4-[1-hydroxy-2-(isopropylamino)ethyl]benzene-1,2-diol hydrochloride
WLN: QR BQ DYQ1MY1&1 &GH
CAS-51-30-9
ISOPRENALINE HYDROCHLORIDE (MART.)
ISOPRENALINE HYDROCHLORIDE [MART.]
SMR000058267
DL-ISOPRENALINE HYDROCHLORIDE [JAN]
ISOPROTERENOL HYDROCHLORIDE (USP-RS)
ISOPROTERENOL HYDROCHLORIDE [USP-RS]
Isoprenaline hydrochloride (VAN)
ISOPRENALINE HYDROCHLORIDE (EP IMPURITY)
ISOPRENALINE HYDROCHLORIDE [EP IMPURITY]
ISOPRENALINE HYDROCHLORIDE (EP MONOGRAPH)
ISOPRENALINE HYDROCHLORIDE [EP MONOGRAPH]
Isoproterenol (hydrochloride)
ISOPROTERENOL HYDROCHLORIDE (USP MONOGRAPH)
ISOPROTERENOL HYDROCHLORIDE [USP MONOGRAPH]
SR-01000075272
Levisoprenaline (hydrochloride)
Iprenol
Sooner
Proternol-S
3,4-Dihydroxy-alpha-[(isopropylamino)methyl]benzyl alcohol hydrochloride
Isuprel (TN)
Proternol-S (TN)
ISOINTRANEFRIN
ISOPREL
Isadrine-hydrochloride
NORISODRINE-H
N-Isopropyl-DL-noradrenaline hydrochloride
ISOVON (CL)
Hydrochloride, Isoproterenol
SCHEMBL7627
ALUDRINE HYDROCHLORIDE
CHEMBL1711
IZADRINE-HYDROCHLORIDE
REGID_for_CID_5807
MLS001304049
MLS001335893
MLS001335894
MLS002153386
component of Aerolone Compound
SPECTRUM1500357
Isoprenaline Hydrochloride,(S)
(y)-Isoproterenol hydrochloride
(?)-Isoproterenol hydrochloride
NIOSH/UX1780000
CHEBI:31453
HY-B0468R
ISOPROPYDRINE HYDROCHLORIDE
HMS1571K16
HMS1920H13
Pharmakon1600-01500357
(.+-.)-Isoprenaline hydrochloride
BCP23375
FAA98495
HY-B0468
(.+-.)-Isoproterenol hydrochloride
Tox21_201272
Tox21_300308
Tox21_500711
CCG-40129
MFCD00064548
NSC757079
s2566
AKOS015895437
AC-8688
BCP9000796
FI33495
LP00711
NC00515
NSC-757079
Isoprenaline (hydrochloride) (Standard)
NCGC00025274-02
NCGC00025274-05
NCGC00094033-01
NCGC00094033-02
NCGC00094061-01
NCGC00094061-02
NCGC00094061-03
NCGC00094061-04
NCGC00254027-01
NCGC00258824-01
NCGC00261396-01
AS-13330
DA-64559
ISOPROTERENOL DL-FORM HYDROCHLORIDE
BCP0726000230
ISOPRENALINE HYDROCHLORIDE [WHO-DD]
ISOPRENALINE HYDROCHLORIDE [WHO-IP]
ISOPROTERENOL HYDROCHLORIDE [VANDF]
DB-053474
(.+-.)-Isopropylnoradrenaline hydrochloride
EU-0100711
I0260
NS00076358
SW197212-2
UX17800000
(-)-N-Isopropyl-L-noradrenaline hydrochloride
VU0244462-4
D01390
EN300-108428
H10806
I 5627
ISOPROTERENOL DL-FORM HYDROCHLORIDE [MI]
ISOPROTERENOL HYDROCHLORIDE [ORANGE BOOK]
SR-01000075272-1
SR-01000075272-3
( inverted question mark)-Isoproterenol hydrochloride
Q26840880
Z1416254508
4-(1-Hydroxy-2-(isopropylamino)ethyl)benzene-1,2-diol HCl
4-(1-Hydroxy-2-(isopropylamino)ethyl)pyrocatechol hydrochloride
ISOPROTERENOL HYDROCHLORIDE COMPONENT OF DUO-MEDIHALER
1, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride
Pyrocatechol, 4-(1-hydroxy-2-(isopropylamino)ethyl)-, hydrochloride
(R)-3,4-Dihydroxy-alpha-(isopropylaminomethyl)benzyl alcohol hydrochloride
.alpha.-(Isopropylaminomethyl)-3,4-dihydroxybenzyl alcohol hydrochloride
1, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride, (+-)-
1-(3,4-DIHYDROXYPHENYL)-2-(ISOPROPYLAMINO)ETHANOL HYDROCHLORIDE
3,4-Dihydroxy-.alpha.-[(isopropylamino)methyl]benzyl alcohol hydrochloride
4-(1-Hydroxy-2-((1-methylethyl)amino)ethyl)-1,2-benzenediol Hydrochloride
Benzyl alcohol,4-dihydroxy-.alpha.-[(isopropylamino)methyl]-, hydrochloride
Isoprenaline hydrochloride, European Pharmacopoeia (EP) Reference Standard
1, 4-[1-hydroxy-2-[(1-methylethyl)amino]ethyl]-, hydrochloride, (.+-.)-
3,4-DIHYDROXY-ALPHA-((ISOPROPYLAMINO)METHYL)-BENZYL ALCOHOL HYDROCHLORIDE
3,4-DIHYDROXY-ALPHA-(ISOPROPYLAMINOMETHYL)BENZYL ALCOHOL HYDROCHLORIDE
4-(1-HYDROXY-2-((METHYLETHYL)AMINO)ETHYL)-1,2-BENZENEDIOL HYDROCHLORIDE
Benzyl alcohol,4-dihydroxy-.alpha.-[(isopropylamino)methyl]-, hydrochloride, (+-)-
Benzyl alcohol,4-dihydroxy-.alpha.-[(isopropylamino)methyl]-, hydrochloride, (.+-.)-
Isoproterenol hydrochloride, United States Pharmacopeia (USP) Reference Standard
1336-89-6
213-438-4