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Droxidopa

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Identification
Molecular formula
C9H13NO4
CAS number
23651-95-8
IUPAC name
4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxy-phenol
State
State

At room temperature, droxidopa is typically in a solid state as a crystalline powder.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
0.00
Boiling point (Kelvin)
0.00
General information
Molecular weight
213.21g/mol
Molar mass
213.2370g/mol
Density
1.3210g/cm3
Appearence

Droxidopa is typically seen as a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxy-phenol

The solubility of 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxy-phenol is influenced by several factors, including its molecular structure and the presence of functional groups. Generally speaking, phenolic compounds like this one exhibit some interesting solubility characteristics:

  • Polarity: The presence of hydroxyl (-OH) and methylamino (-NH2) groups enhances the compound's polarity, making it more soluble in polar solvents such as water.
  • Organic Solvents: This compound is likely to have good solubility in organic solvents due to its hydrophobic methoxy (-OCH3) groups, which can interact well with nonpolar environments.
  • Temperature Effects: Higher temperatures typically increase the solubility of many organic compounds, which may also apply to this phenolic compound.

It is noteworthy that solubility is often context-dependent, whereby factors such as pH and the presence of other solutes can affect the solubility behavior. For instance, in acidic conditions, the protonation of the amino group may alter solubility in water.

In summary, the solubility of 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxy-phenol can be characterized as being:

  1. Moderately soluble in water due to hydroxyl and amino groups.
  2. Highly soluble in organic solvents due to methoxy groups.
  3. Variable depending on environmental conditions such as temperature and pH.
Interesting facts

Interesting Facts about 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxy-phenol

This compound, commonly referenced in the field of medicinal chemistry, possesses a unique structure that contributes to its bioactivity. Known for its potential pharmacological applications, it has garnered attention for several key reasons:

  • Bioactive Properties: The presence of both a methoxy group and a hydroxyl group marks this compound as a potential candidate for therapeutic uses, particularly in areas related to neurochemistry.
  • Structural Diversity: The combination of dimethoxy-substituted phenol with an amino-ethyl moiety creates a fascinating structural diversity that may influence its interaction with biological targets.
  • Molecular Interaction: Research has suggested that this compound could interact effectively with neurotransmitter systems, making it of interest for studies related to mental health and cognitive function.
  • Synthetic Pathways: The synthetic routes leading to this compound can be intricate, often involving various steps of functionalization and protection, which illustrates the complexity of organic synthesis.

In summary, 4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxy-phenol exemplifies a compound that bridges fundamental chemistry with the world of pharmacology. As developments in this area continue to evolve, further research may reveal even more intriguing applications and mechanisms of action.

Synonyms
Dimethophrine
1-(4-Hydroxy-3,5-dimethoxyphenyl)-2-methylaminoethanol
RefChem:920290
Dimetofrine
22950-29-4
Anassicol
dimetrophine
Dimetofrina
Dimetofrine [INN]
4-[1-hydroxy-2-(methylamino)ethyl]-2,6-dimethoxyphenol
BOM1J10QQM
1-(3,5-Dimethoxy-4-hydroxyphenyl)-2-(methylamino)ethanol
Dimetofrine (INN)
Anassicol; Dimethophrine; Dimetrophine
Dimetofrinum
UNII-BOM1J10QQM
Dimetofrinum [INN-Latin]
Dimetofrina [INN-Spanish]
DTXSID60865076
EINECS 245-348-6
DIMETOFRINE [MI]
DIMETOFRINE [WHO-DD]
SCHEMBL309475
CHEMBL2105040
CHEBI:134932
4-Hydroxy-3,5-dimethoxy-alpha-[(methylamino)methyl]benzenemethanol
Benzenemethanol, 4-hydroxy-3,5-dimethoxy-alpha-((methylamino)methyl)-
Benzyl alcohol, 4-hydroxy-3,5-dimethoxy-alpha-((methylamino)methyl)-
DB13494
NS00048132
D07149
EN300-1858331
Q5277352
4-Hydroxy-3,5-dimethoxy-alpha-((methylamino)methyl)benzyl alcohol
4-HYDROXY-3,5-DIMETHOXY-.ALPHA.-((METHYLAMINO)METHYL)BENZYL ALCOHOL
BENZYL ALCOHOL, 4-HYDROXY-3,5-DIMETHOXY-.ALPHA.-((METHYLAMINO)METHYL)-