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1-Piperidinebutanoic acid

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Identification
Molecular formula
C9H17NO2
CAS number
2218-23-7
IUPAC name
4-(1-piperidyl)butanoic acid
State
State

At room temperature, 1-Piperidinebutanoic acid is typically in a solid state. It may absorb moisture if exposed to a humid environment, which can influence its handling and storage conditions.

Melting point (Celsius)
98.00
Melting point (Kelvin)
371.20
Boiling point (Celsius)
385.20
Boiling point (Kelvin)
658.40
General information
Molecular weight
183.25g/mol
Molar mass
183.2470g/mol
Density
1.0970g/cm3
Appearence

The compound typically appears as a white or off-white solid powder. It is crystalline in nature and might exhibit slight hygroscopic properties when exposed to air.

Comment on solubility

Solubility of 4-(1-piperidyl)butanoic acid

4-(1-piperidyl)butanoic acid, with its unique structure, exhibits solubility characteristics that are noteworthy. This compound is a type of amino acid derivative, and its solubility profile can be influenced by several factors:

  • Polarity: The presence of both the piperidine ring and the carboxylic acid group gives this compound moderate polarity, suggesting it is soluble in polar solvents like water.
  • Hydrogen Bonding: The availability of hydrogen bonding sites in the carboxylic group enhances the molecule's ability to interact with water molecules, further promoting solubility.
  • pH Dependence: The solubility of 4-(1-piperidyl)butanoic acid may change with pH due to the protonation and deprotonation of the carboxylic acid group, which can affect its overall charge and solubility in aqueous solutions.

As a general observation, compounds similar to 4-(1-piperidyl)butanoic acid are often soluble in organic solvents as well, facilitating their use in various chemical applications. Thus, while the compound’s precise solubility can depend on environmental conditions, it typically presents favorable solubility in biological and pharmacological contexts.

Interesting facts

Exciting Insights into 4-(1-Piperidyl)butanoic Acid

4-(1-Piperidyl)butanoic acid, often referred to simply as a significant derivative of piperidine, presents intriguing characteristics and applications in the field of chemistry and pharmacology. This compound is known for its unique structure and functionality, making it a subject of interest among researchers.

Key Characteristics and Applications

  • Pharmaceutical Relevance: 4-(1-Piperidyl)butanoic acid serves as a crucial building block in the synthesis of various medications. Its derivatives are explored for their potential as therapeutic agents in treating conditions such as anxiety and depression.
  • Neuroscience Studies: Researchers have studied this compound for its effects on neurotransmitter systems, particularly GABA receptor modulation, which is essential for maintaining the balance between excitation and inhibition in the brain.
  • Versatile Synthesis: The synthesis of 4-(1-Piperidyl)butanoic acid is notable for its versatility. Different methods can be employed to create this compound, leading to a range of applications in organic chemistry.
  • Research and Development: Its unique properties make it an appealing subject for further research, with ongoing studies exploring its potential in drug development and its role in various biological mechanisms.

Moreover, the compound's research indicates its potential as a therapeutic candidate. As scientists continue to unravel the complexities of its interactions within biological systems, we can anticipate more impactful applications and discoveries emerging from this fascinating compound.

Synonyms
1-Piperidinebutanoic acid
4-Piperidinebutyric acid
gamma-Piperidinobutyric acid
BUTYRIC ACID, 4-PIPERIDINO-
DF 473
BRN 0117549
DTXSID10196928
5-20-03-00049 (Beilstein Handbook Reference)
DTXCID50119419
1-Piperidinebutanoic acid (9CI)
4-(piperidin-1-yl)butanoic acid
4672-16-6
4-piperidin-1-ylbutanoic acid
4-Piperidinobutyric acid
4-Piperidin-1-ylbutanoic acid x1hcl
4-Piperidin-1-yl-butyric acid
NSC15135
NSC-15135
4-(1-piperidinyl)butanoic acid
NCIStruc1_000333
NCIStruc2_000967
SCHEMBL472290
4-(piperidin-1-yl)butanoicacid
CHEMBL1401348
BGAVZPPPWLEAKZ-UHFFFAOYSA-N
NCI15135
BBL029460
CCG-38062
NCGC00013195
STK946245
AKOS003593801
FP57479
FS-6348
SB42129
NCGC00013195-02
NCGC00013195-03
NCGC00096316-01
NCI60_001061
DB-349521
CS-0117688
AB00640239-02
AB00640239-05
A1-02325
8-(1,2-Dimethylheptyl)-1,3,4,5-tetrahydro-5,5-dimethyl-2-(2-propynyl)-2H-(1)benzopyrano(4,3-c)pyridin-10-yl ester,monohydrochloride