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N-Phthaloyl-4-aminobutyric acid

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Identification
Molecular formula
C12H12N2O3
CAS number
64669-00-3
IUPAC name
4-(1,3-dioxoisoindolin-2-yl)butanamide
State
State

At room temperature, the compound is in a solid state. It is stable under normal conditions and does not readily sublimate or dissolve without specific solvents.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
403.60
Boiling point (Kelvin)
676.75
General information
Molecular weight
247.23g/mol
Molar mass
247.2350g/mol
Density
1.3540g/cm3
Appearence

4-(1,3-dioxoisoindolin-2-yl)butanamide typically appears as a white to off-white crystalline powder. Its crystalline nature gives it a solid form with well-defined edges visible under magnification.

Comment on solubility

Solubility of 4-(1,3-dioxoisoindolin-2-yl)butanamide

The compound 4-(1,3-dioxoisoindolin-2-yl)butanamide exhibits notable solubility characteristics influenced by its unique structure. Understanding its solubility can help predict its behavior in various solvents and applications. Here are some key points regarding its solubility:

  • Solvent Polarity: This compound is likely to have different solubility in polar and non-polar solvents. Generally, compounds with polar functional groups tend to dissolve better in polar solvents like water or alcohols.
  • Temperature Dependency: The solubility may increase with temperature, as is typical for many organic compounds, which can lead to enhanced interactions with the solvent molecules.
  • pH Effects: Since it contains an amide group, its solubility might also be influenced by the pH of the solution. For instance, changes in pH can affect the ionization state of the compound, potentially increasing solubility in acidic or basic environments.
  • Hydrogen Bonding: The presence of functional groups capable of hydrogen bonding can promote solubility in water, which is critical for biological applications.

In conclusion, while 4-(1,3-dioxoisoindolin-2-yl)butanamide likely possesses good solubility in compatible solvents, its behavior will vary considerably based on environmental conditions such as solvent type, temperature, and solution pH. Understanding these factors is crucial for its practical applications.

Interesting facts

Exploring 4-(1,3-dioxoisoindolin-2-yl)butanamide

The compound 4-(1,3-dioxoisoindolin-2-yl)butanamide represents a fascinating intersection of structure and potential biological activity. Here are some notable aspects:

  • Structural Uniqueness: The presence of the dioxoisoindole moiety provides a unique framework. This structure is known for its significant contribution to pharmaceutical chemistry and can influence the compound's activity.
  • Versatile Applications: Compounds similar to this one are often explored for their roles in medicinal chemistry, where they may serve as potential drug candidates. The ability to modify the butanamide side can lead to varied pharmacological properties.
  • Research Importance: Research studies often investigate such compounds for their enzyme inhibition capabilities, particularly in the realm of cancer therapy and other diseases. The dioxo group can stabilize interactions with enzymatic targets.
  • Functional Groups: Understanding how the amide group influences the compound’s reactivity and interaction in biological systems is crucial. Amides are known to play a role in hydrogen bonding, affecting solubility and bioactivity.

As noted in the field of organic chemistry, most drug-like molecules are not perfectly soluble. This brings a deeply engaging challenge to chemists: how to balance stability and solubility. "Chemistry is about change; how do we make a compound effective while retaining its character?" is a guiding principle in such explorations.

Ultimately, the study of 4-(1,3-dioxoisoindolin-2-yl)butanamide opens doors to understanding complex interactions in biological systems and emphasizes the continuous innovation in drug discovery.

Synonyms
4-Phthalimidobutyramide
2-ISOINDOLINEBUTYRAMIDE, 1,3-DIOXO-
1,3-Dioxo-2-isoindolinebutyramide
3459-33-4
Phthalimide, N-(carbamoylpropyl)-
BRN 0018270
2H-Isoindole-2-butanamide, 1,3-dihydro-1,3-dioxo-
DTXSID30188148
DTXCID60110639
5-21-10-00482 (beilstein handbook reference)
4-(1,3-dioxoisoindol-2-yl)butanamide
Oprea1_386084
SCHEMBL5041554
MFCD00709196
AKOS002964806
4-(1,3-dioxoisoindolin-2-yl) butanamide
4-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)butanamide