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4-(1H-indol-3-ylmethyl)morpholine

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Identification
Molecular formula
C13H16N2O
CAS number
17216-53-0
IUPAC name
4-(1H-indol-3-ylmethyl)morpholine
State
State
At room temperature, 4-(1H-indol-3-ylmethyl)morpholine is typically a solid. It is stable under normal conditions but should be handled with care.
Melting point (Celsius)
205.00
Melting point (Kelvin)
478.00
Boiling point (Celsius)
400.00
Boiling point (Kelvin)
673.00
General information
Molecular weight
230.31g/mol
Molar mass
230.3100g/mol
Density
1.2350g/cm3
Appearence
4-(1H-indol-3-ylmethyl)morpholine is typically found in a crystalline solid form. The compound features a complex structure due to the presence of both indole and morpholine rings, which give it unique structural characteristics.
Comment on solubility

Solubility of 4-(1H-indol-3-ylmethyl)morpholine

The solubility of 4-(1H-indol-3-ylmethyl)morpholine in various solvents is an important characteristic for its applications in research and pharmaceutical industries. This compound exhibits distinct solubility behavior in different environments:

  • Water: It is generally sparingly soluble in water, which limits its direct application in aqueous systems.
  • Organic Solvents: It shows improved solubility in organic solvents such as:
    • Dimethyl sulfoxide (DMSO)
    • Ethanol
    • Acetone
  • pH Dependence: The solubility can also be affected by the pH of the solution, with modifications in ionization potentially altering its solubility profile.

In conclusion, while 4-(1H-indol-3-ylmethyl)morpholine may not be highly soluble in water, its solubility in organic solvents expands its utility in various applications. Understanding its solubility characteristics is crucial for optimizing its use in synthesis and biomedical research.

Interesting facts

Exploring 4-(1H-indol-3-ylmethyl)morpholine

4-(1H-indol-3-ylmethyl)morpholine is a fascinating compound that has garnered interest in various scientific fields, particularly in medicinal chemistry and pharmacology. This compound features a unique structure that combines both indole and morpholine moieties, lending itself to a range of potential biological activities.

Key Characteristics

  • Bioactivity: Compounds like 4-(1H-indol-3-ylmethyl)morpholine are studied for their potential as therapeutic agents, particularly in treating neurological disorders and cancer.
  • Diverse Applications: The structural versatility of this compound allows it to be engineered for various purposes, including serving as a ligand in drug design.
  • Indole Framework: The presence of the indole ring is notable; indoles are recognized for their significant role in biological processes and have been linked to various pharmacological properties.

Research and Development

Ongoing research into 4-(1H-indol-3-ylmethyl)morpholine is focused on understanding its mechanism of action and evaluating its efficacy in clinical settings. Many studies emphasize:

  • Potential as Anticancer Agents: Investigations are underway to determine how this compound can inhibit tumor growth and promote apoptosis in cancer cells.
  • Neurological Benefits: Researchers are also looking into its effects on neurotransmitter systems, with the hope of developing treatments for conditions like depression and anxiety.
  • Drug Design: Thanks to its structural features, it serves as a template for designing new compounds with enhanced activity and reduced side effects.

Conclusion

In summary, 4-(1H-indol-3-ylmethyl)morpholine stands out as a compound of significant interest in scientific research. Its unique structural attributes and potential applications make it a promising candidate for future developments in medicinal chemistry. As we continue to explore its properties, we may uncover novel solutions to pressing health challenges.

Synonyms
5379-88-4
3-(Morpholinomethyl)indole
3-MORPHOLIN-4-YLMETHYL-1H-INDOLE
INDOLE, 3-(MORPHOLINOMETHYL)-
4-(1H-indol-3-ylmethyl)morpholine
4-((1H-indol-3-yl)methyl)morpholine
NSC-33090
3-(morpholin-4-ylmethyl)-1H-indole
8NA1X69AKC
3-[(morpholin-4-yl)methyl]-1H-indole
NSC 33090
BRN 0193005
NSC33090
UNII-8NA1X69AKC
Oprea1_206610
Oprea1_207924
4-27-00-00551 (Beilstein Handbook Reference)
MLS001183533
3-(4-Morpholinylmethyl)indole
4-(3-Indolylmethyl)morpholine
CHEMBL134872
SCHEMBL1856027
NIOSH/QE5220000
DTXSID90202071
VHGISLOQNDQFIW-UHFFFAOYSA-N
HMS2835M19
Morpholine, 4-(3-indolylmethyl)-
Morpholine, N-[3-indolyl]methyl-
3-(4-Morpholinylmethyl)-1H-indole
STK000077
AKOS005374024
1H-Indole, 3-(4-morpholinylmethyl)-
3-(4-Morpholinylmethyl)-1H-indole #
NCGC00247306-01
SMR000502002
CS-0319870
QE52200000
SR-01000196341
SR-01000196341-1