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Norepinephrine

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Identification
Molecular formula
C8H11NO3
CAS number
51-41-2
IUPAC name
4-[(1S,2R)-2-amino-1-hydroxy-propyl]benzene-1,2-diol
State
State

At room temperature, norepinephrine is typically found in a solid state as a powder. In clinical settings, it is often used in solution form for intravenous administration.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
201.00
Boiling point (Kelvin)
474.15
General information
Molecular weight
169.18g/mol
Molar mass
169.1770g/mol
Density
1.2200g/cm3
Appearence

Norepinephrine typically appears as a white to off-white powder that is hygroscopic. It is often used in its salt forms, which may slightly alter its appearance depending on the specific salt form (e.g., bitartrate, hydrochloride). The pure compound is not usually found in its isolated state outside of laboratory settings.

Comment on solubility

Solubility of 4-[(1S,2R)-2-amino-1-hydroxy-propyl]benzene-1,2-diol

The solubility of 4-[(1S,2R)-2-amino-1-hydroxy-propyl]benzene-1,2-diol can be characterized by a variety of factors that influence its behavior in different solvents. In general, the presence of hydroxyl groups and an amino group tends to enhance solubility in polar solvents, notably water. This is due to the ability of these functional groups to form hydrogen bonds:

  • Hydrogen Bonding: The hydroxyl (-OH) groups are capable of forming strong hydrogen bonds with water molecules, thus promoting solubility.
  • Polarity: Being a polar molecule, 4-[(1S,2R)-2-amino-1-hydroxy-propyl]benzene-1,2-diol is likely to be more soluble in polar solvents compared to non-polar solvents.
  • Chain Length: The presence of the propyl chain may impact solubility, where increasing hydrophobic character may reduce solubility in water but may allow for solubility in organic solvents.

For practical applications, the solubility of this compound in various solvents is crucial, particularly in drug formulation and synthesis. A useful maxim in chemistry states, “like dissolves like”, which means that compounds with similar polarities tend to be soluble in each other. Thus, this compound would likely exhibit good solubility in:

  • Water
  • Ethanol
  • Dimethyl sulfoxide (DMSO)

Understanding the solubility characteristics of this compound can lead to better processing, handling, and utilization in various scientific endeavors.

Interesting facts

Interesting Facts about 4-[(1S,2R)-2-amino-1-hydroxy-propyl]benzene-1,2-diol

This compound, known for its intricate molecular structure, is more than just a complex name. Chemically categorized under the group of phenolic compounds, it possesses unique properties that contribute to various biological and chemical processes. Here are some notable aspects of this compound:

  • Chiral Center: This compound features a chiral center due to the presence of a (1S,2R) configuration. The different stereoisomers can lead to varied biological activities, stressing the importance of stereochemistry in drug design.
  • Biological Relevance: Phenolic compounds, like this one, are often found in nature and play significant roles in plant defense mechanisms. Their antioxidant characteristics make them critical in the study of health benefits and potential medicinal applications.
  • Potential Applications: The structural attributes of 4-[(1S,2R)-2-amino-1-hydroxy-propyl]benzene-1,2-diol suggest potential uses in pharmaceuticals, especially as intermediates in the synthesis of bioactive compounds.
  • Research Interest: Ongoing research explores the unique aspects of this compound in the context of its reactivity and interaction with biological systems. It offers exciting avenues for discovering new therapeutic agents.

As a chemistry student or a scientist, one would appreciate the direct connection between such compounds and their implications in both synthetic and natural chemistry. The complexities of compounds like 4-[(1S,2R)-2-amino-1-hydroxy-propyl]benzene-1,2-diol highlight the endless possibilities within the vast realm of chemical exploration.

In the words of renowned chemist Linus Pauling, “The best way to have a good idea is to have lots of ideas.” Exploring compounds such as this one is a prime example of how detailed molecular structure can lead to innovative ideas and advancements in science.

Synonyms
NCGC00163349-01
orb1943113
CHEMBL1160982
HY-B1708
CS-0013709