Skip to main content

Thioflavin T

ADVERTISEMENT
Identification
Molecular formula
C17H19N3S
CAS number
2390-54-7
IUPAC name
4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-dimethyl-aniline
State
State

At room temperature, Thioflavin T is typically in a solid state, most commonly provided as a powder. It is used in solution for fluorescence applications.

Melting point (Celsius)
186.00
Melting point (Kelvin)
459.15
Boiling point (Celsius)
382.60
Boiling point (Kelvin)
655.80
General information
Molecular weight
318.42g/mol
Molar mass
318.4240g/mol
Density
1.0803g/cm3
Appearence

Thioflavin T appears as a yellow crystalline powder or crystals. In solution, it typically exhibits a yellow-green color and fluoresces strongly when bound to amyloid fibrils, displaying intense green fluorescence under ultraviolet light.

Comment on solubility

Solubility of 4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-dimethyl-aniline

The solubility of 4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-dimethyl-aniline is an intriguing topic, particularly because of its structural complexities. Here are key points regarding its solubility characteristics:

  • Solvent Dependence: This compound shows varying solubility in different solvents. It is generally more soluble in organic solvents such as ethanol and dichloromethane compared to water.
  • Polar vs. Non-Polar: The compound's structure suggests that it is moderately polar due to the presence of the dimethylamino group, yet it also exhibits some non-polar characteristics from the aromatic and benzothiazole components.
  • Temperature Effects: Increasing temperature can enhance solubility in non-polar organic solvents, making it important to consider temperature when dissolving this compound.
  • pH Influence: The solubility may also be affected by the pH of the solution. In acidic conditions, protonation of the amino group can lead to increased solubility.
  • Practical Applications: Understanding solubility is critical for applications in organic synthesis and pharmaceutical formulations, where achieving the right concentration is vital.

In conclusion, while 4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-dimethyl-aniline exhibits limited solubility in water, its solubility profile in organic solvents is favorable for various applications, making it a compound of interest in chemical research.

Interesting facts

Interesting Facts About 4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-dimethyl-aniline

This compound, known for its vibrant color and unique structural features, is a fascinating entity in the realm of organic chemistry. Here are some captivating insights:

  • Structural Diversity: The compound features a characteristic vinyl functionality attached to a benzothiazole moiety. This structural diversity imparts unique electronic properties, making it a subject of interest for various applications.
  • Potential Applications: Due to its distinctive properties, this compound is explored for use as a fluorescent dye, and may have potential in organic light-emitting diodes (OLEDs) and sensors. Its ability to emit light can be harnessed in creative ways.
  • Biological Significance: Compounds similar in structure are often investigated for their biological activities, including antimicrobial and anticancer properties. The benzothiazole ring, in particular, has been linked to various pharmacological effects.
  • Research Interest: The unique combination of elements in this compound piques the interest of researchers looking to develop novel materials with enhanced functionalities. Collaborations between chemists and materials scientists are becoming increasingly common in this area.
  • Chemical Reactions: The presence of the dimethyl aniline group opens pathways for various electrophilic substitution reactions, providing chemists with tools to modify the molecule further for specific applications.

In summary, 4-[2-(1,3-benzothiazol-2-yl)vinyl]-N,N-dimethyl-aniline is more than just a chemical compound; it represents a bridge between fundamental research and practical applications, showcasing the beauty and complexity of organic chemistry.

Synonyms
2-(p-N,N-dimethylaminostyryl)benzothiazole
(E)-4-(2-(benzo[d]thiazol-2-yl)vinyl)-N,N-dimethylaniline
DTXSID4061832
MVMOMSLTZMMLJR-UHFFFAOYSA-N
NCI60_003778
NS00025316