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Asenapine

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Identification
Molecular formula
C22H27NO2S
CAS number
65547-78-6
IUPAC name
4-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propyl]sulfanylethyl]morpholine
State
State

This compound is in a solid state at room temperature.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
401.57g/mol
Molar mass
401.5720g/mol
Density
1.2000g/cm3
Appearence

This compound is typically a white to off-white crystalline powder, reflecting its solid state with a crystalline structure at room temperature.

Comment on solubility

Solubility of 4-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propyl]sulfanylethyl]morpholine

The solubility of 4-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propyl]sulfanylethyl]morpholine can be quite complex due to its intricate structure. Here are some key points regarding its solubility characteristics:

  • Polarity: The presence of multiple functional groups can result in a varying degree of polarity, affecting solubility in polar vs. non-polar solvents.
  • Solvent Compatibility: This compound may show better solubility in organic solvents such as dimethyl sulfoxide (DMSO) or ethanol compared to water.
  • Hydrogen Bonding: The morpholine moiety can engage in hydrogen bonding, potentially enhancing solubility in protic solvents.
  • Temperature Dependence: It's notable that solubility often increases with temperature; thus, warming the solvent may aid in dissolving this compound more effectively.

As a general observation, structurally complex compounds like this one tend to exhibit varied solubility profiles, and empirical experimentation is essential to ascertain specific solubility attributes under different conditions.

Interesting facts

Interesting Facts about 4-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propyl]sulfanylethyl]morpholine

This compound, with a complex structure, is an intriguing example of organic chemistry's ability to create diverse molecular architectures. The presence of a morpholine ring, combined with a naphthylmethyl moiety and a tetrahydrofuran group, showcases the elaborate relationships between structure and function in medicinal chemistry.

Key Features:

  • Morpholine Ring: The cyclic amine structure of morpholine often contributes to the compound's ability to interact with biological targets, making it a relevant scaffold in drug design.
  • Tetrahydrofuran Group: This part of the molecule introduces an element of flexibility due to its alicyclic nature, enabling conformational variations essential for binding to specific biological receptors.
  • Sulfanylethyl Linker: The sulfur-containing side chain provides unique reactivity and can enhance pharmacological properties through the formation of disulfide bonds or modulation of electronic properties.

The compound's synthetic route typically involves multi-step reactions, demonstrating the art and science of organic synthesis. Such compounds are often evaluated for their biological activity, which can range from anti-cancer to anti-inflammatory effects. As researchers delve deeper into the functionality of these complex molecules, they reveal:

  • Potent Biological Activity: Interaction with specific enzymes or receptors can lead to desired therapeutic outcomes.
  • Potential Side Effects: The drug development process must carefully assess these complexities to ensure safety and efficacy.
  • Structure-Activity Relationship (SAR): Understanding how variations in structure affect biological activity can inform the design of next-generation therapeutics.

As we advance in pharmaceutical chemistry, compounds like 4-[2-[2-(1-naphthylmethyl)-3-tetrahydrofuran-2-yl-propyl]sulfanylethyl]morpholine continue to illustrate the beauty of chemical diversity and its potential impact on human health. Scientists continue to be excited by the possibilities that arise from such intricate molecular designs.