Indomethacin | Solubility of Things

Identification

Molecular formula

C₁₉H₁₆ClNO₄

CAS number

53-86-1

IUPAC name

4-[[2-[[3-(1H-indol-3-yl)-3-methyl-2-(methylamino)butanoyl]amino]-3,3-dimethyl-butanoyl]-methyl-amino]-2,5-dimethyl-hex-2-enoic acid

State

It is a solid at room temperature.

Melting point (Celsius)

159.00

Melting point (Kelvin)

432.00

Boiling point (Celsius)

700.15

Boiling point (Kelvin)

973.15

General information

Molecular weight

357.79g/mol

Molar mass

357.7890g/mol

Density

1.3280g/cm³

Appearence

Indomethacin is a white to yellow crystalline powder, practically insoluble in water. It has a characteristic odor.

Comment on solubility

Solubility of 4-[[2-[[3-(1H-indol-3-yl)-3-methyl-2-(methylamino)butanoyl]amino]-3,3-dimethyl-butanoyl]-methyl-amino]-2,5-dimethyl-hex-2-enoic acid

The solubility of the compound with the formula C₁₉H₁₆ClNO₄ is an essential characteristic that can impact its applications and viability in various chemical environments. When considering the solubility, several factors must be taken into account:

Polarity: The presence of polar functional groups such as amino and carboxylic acid can enhance solubility in polar solvents, notably water.
Hydrophobic Regions: The aromatic indole structure and other hydrocarbon portions may confer hydrophobic properties, potentially reducing solubility in aqueous environments.
Influence of Chlorine: The presence of the chlorine atom can impact the overall solubility, often leading to varying degrees of interaction with solvent molecules.

In summary, the solubility of this complex compound is likely to be moderate, with potential solubility in organic solvents being higher compared to water due to its hydrophobic characteristics. As solubility characteristics play a crucial role in the behavior of compounds in biochemical systems, understanding it is paramount for effective application in research and industry.

Interesting facts

Interesting Facts about 4-[[2-[[3-(1H-indol-3-yl)-3-methyl-2-(methylamino)butanoyl]amino]-3,3-dimethyl-butanoyl]-methyl-amino]-2,5-dimethyl-hex-2-enoic acid

This compound, frequently referenced in the realm of peptide synthesis and pharmacological research, showcases a unique structure that intrigues chemists and biologists alike. Here are some engaging insights:

Complex Structure: The intricate arrangement of functional groups, including an indole moiety, highlights the compound's potential for various biological interactions, making it a valuable candidate for studying drug mechanisms.
Potential Biological Activity: The presence of indoles in many bioactive compounds suggests that this compound may exhibit significant pharmacological properties, inspiring investigations into its effects on human health.
Peptide Analog: Given its resemblance to peptide structures, this compound may serve as a template for designing new therapeutic agents, especially in targeting specific receptors or enzymes.
Research Applications: Scientists are excited about its applications in areas such as cancer research, as compounds with similar structures have shown promise in inhibiting tumor growth and promoting apoptosis.
Fatty Acid Derivative: This compound features a fatty acid moiety, suggesting its function may extend to metabolic pathways, potentially influencing lipid metabolism.

The exploration of this compound not only emphasizes the vast potential of organic chemistry in developing new therapeutics but also inspires ongoing research into understanding its multifaceted roles in biological systems. Scientists continue to unravel the complexities of such compounds as they seek to enhance drug efficacy and reduce side effects in pharmacology.

In conclusion, this compound represents a captivating intersection of chemical complexity and potential medical application, making it a subject of great interest for researchers across multiple scientific disciplines.