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Indolylpentylmorpholine

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Identification
Molecular formula
C19H29N3O
CAS number
1636-73-7
IUPAC name
4-[2-[3-(1H-indol-3-yl)pyrrolidin-1-yl]ethyl]morpholine
State
State

At room temperature, Indolylpentylmorpholine is in a solid state. This compound is stable under normal temperatures and pressures.

Melting point (Celsius)
153.00
Melting point (Kelvin)
426.00
Boiling point (Celsius)
405.60
Boiling point (Kelvin)
678.80
General information
Molecular weight
315.43g/mol
Molar mass
315.4330g/mol
Density
1.2000g/cm3
Appearence

Indolylpentylmorpholine appears as a white to off-white crystalline powder. It can have a slight odor, characteristic of organic compounds containing nitrogen (amines).

Comment on solubility

Solubility of 4-[2-[3-(1H-indol-3-yl)pyrrolidin-1-yl]ethyl]morpholine

The solubility of 4-[2-[3-(1H-indol-3-yl)pyrrolidin-1-yl]ethyl]morpholine is influenced by its unique chemical structure and functional groups. Here are some critical factors regarding its solubility:

  • Polar vs. Non-Polar Characteristics: This compound contains both polar and non-polar elements due to the presence of a morpholine ring and the indole structure, which can affect solubility in various solvents.
  • Solvent Compatibility: Aqueous solubility is generally lower for compounds with large non-polar regions. Therefore, it may be more soluble in organic solvents such as chloroform and methanol than in water.
  • Hydrogen Bonding: The morpholine and pyrrolidine groups may facilitate hydrogen bonding with solvents, potentially increasing solubility in polar media.
  • pH Dependence: Solubility could also vary with pH; under acidic or basic conditions, the ionizability of functional groups can change, affecting solubility profiles.

In conclusion, the solubility of 4-[2-[3-(1H-indol-3-yl)pyrrolidin-1-yl]ethyl]morpholine is likely to be moderate in polar solvents and may exhibit significant differences based on molecular interactions and solvent characteristics. Understanding these factors is essential for predicting the compound's behavior in various environments.

Interesting facts

Interesting Facts about 4-[2-[3-(1H-indol-3-yl)pyrrolidin-1-yl]ethyl]morpholine

This compound, known for its intricate structure, plays a significant role in various chemical fields, particularly in medicinal chemistry. It combines both indole and morpholine functionalities, making it a subject of interest for researchers. Here are some intriguing aspects of this complex compound:

  • Structural Design: The compound features a unique combination of indole and morpholine, both of which are vital in many biological activities. Indoles are frequently found in pharmacologically active compounds, while morpholines are often used in drug design.
  • Potential Applications: Due to its structure, this compound may exhibit potential as a therapeutic agent. Researchers are exploring its effects on various biological systems, particularly in neurotransmitter modulation and receptor binding.
  • Research Interest: The compound's ability to cross the blood-brain barrier makes it a candidate for studying neurological disorders. Its action on the central nervous system could provide insights into drug development for conditions like depression or anxiety.
  • Synthetic Methods: The synthesis of this compound involves multiple steps, often requiring expertise in organic synthesis techniques. Researchers emphasize the importance of optimizing reaction conditions to improve yield and purity.
  • Intermolecular Interactions: Understanding how this compound interacts with other molecules is crucial. Investigating its structure-activity relationship (SAR) can aid in predicting its efficacy and safety profile.

In summary, 4-[2-[3-(1H-indol-3-yl)pyrrolidin-1-yl]ethyl]morpholine presents a fascinating area of study with its potential implications in pharmacology and medicinal chemistry. The ongoing research regarding its biological properties and applications continues to excite scientists in the field.

Synonyms
3-(1-(2-(4-morpholinyl)ethyl)-3-pyrrolidinyl)-1H-indole
NSC43513
3671-02-1
NCI60_004009
CHEMBL2008844