Skip to main content

Raloxifene

ADVERTISEMENT
Identification
Molecular formula
C28H27NO4
CAS number
84449-90-1
IUPAC name
4-[2-(3,5-dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]piperidine-2,6-dione
State
State

At room temperature, Raloxifene is in a solid state. It is mostly handled as tablets in medicinal formulations.

Melting point (Celsius)
140.00
Melting point (Kelvin)
413.15
Boiling point (Celsius)
450.00
Boiling point (Kelvin)
723.15
General information
Molecular weight
473.57g/mol
Molar mass
473.5690g/mol
Density
1.2700g/cm3
Appearence

Raloxifene typically appears as a white to off-white crystalline powder. This purified form is not frequently encountered in open environments, as it is usually administered in a tablet form in pharmaceutical contexts.

Comment on solubility

Solubility of 4-[2-(3,5-dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]piperidine-2,6-dione

The solubility of the compound 4-[2-(3,5-dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]piperidine-2,6-dione (C28H27NO4) is influenced by its complex molecular structure. Understanding the solubility of such compounds can be critical in various scientific applications. Here are some key points to consider:

  • Polarity: With multiple functional groups present, including hydroxyl and carbonyl groups, the compound shows a mixed polarity character which can influence its solubility in different solvents.
  • Solvent Effects: Generally, compounds like this tend to have better solubility in polar solvents such as water, ethanol, or DMSO, especially when considering the hydroxyl group that enhances hydrogen bonding.
  • Temperature Dependence: The solubility may also vary with temperature, and an increase in temperature often enhances the solubility of organic compounds in solvents.
  • Effect of pH: Since the compound contains both acidic and basic functionalities, changes in pH could alter the ionization state, further impacting its solubility profile.

In conclusion, the solubility of C28H27NO4 is not only dependent on its molecular structure but also its interactions with solvents. For precise applications and formulations, evaluating solubility under varying conditions is essential.

Interesting facts

Interesting Facts about 4-[2-(3,5-Dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]piperidine-2,6-dione

This compound, known for its complex structure, contains a unique fusion of piperidine and cyclohexanone moieties, which adds to its intriguing characteristics. Here are some fascinating insights:

  • Diverse Applications: Compounds of this nature are often explored for their potential roles in pharmaceuticals and bioactive molecules, highlighting their significance in medicinal chemistry.
  • Structural Complexity: The presence of multiple functional groups, including the ketone and hydroxyl groups, suggests potential reactivity and the possibility for various chemical transformations.
  • Cyclic Framework: The integration of a cyclohexyl ring not only stabilizes the compound but also affects its biological activity, making it a point of interest in structure-activity relationship studies.
  • Dimethyl Substituents: The 3,5-dimethyl groups may enhance lipophilicity, potentially improving membrane permeability—a crucial factor in drug design.
  • Research Potential: Given its distinctive structure, the compound is likely to be evaluated in various research settings, including studies on its pharmacological effects or its role as an intermediate in organic synthesis.

As a chemistry student or scientist, delving into the properties and applications of such compounds can lead to advancements in understanding chemical behaviors and developing new therapeutic agents. The exploration of 4-[2-(3,5-dimethyl-2-oxo-cyclohexyl)-2-hydroxy-ethyl]piperidine-2,6-dione epitomizes the fascinating intersection of chemistry with practical applications.

Synonyms
Isocycloheximide
4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]piperidine-2,6-dione
6746-42-5
17280-60-3
4-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-2,6-piperidinedione
D-Isocycloheximide
Caswell No. 504C
4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)piperidine-2,6-dione
EPA Pesticide Chemical Code 374700
Actidione;Naramycin A;CHX
Glutarimide, 3-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-
(Cycloheximide CHX)
(+)-3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide
Glutarimide, 3-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (+)-
CHEMBL225699
MEGxm0_000238
SCHEMBL1714687
ACon0_000589
ACon1_002312
CHEBI:91792
3-[(2R)-2-[(1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl]-2-hydroxyethyl]glutarimide
DTXSID801349530
HMS3267I17
Naramycin A; NSC 185;Actidione
4-((2R)-2-((1S,3S,5S)-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-2,6-piperidinedione
ALBB-023622
BCP28121
STL570292
AKOS015900576
NCGC00169964-01
NCGC00169964-02
NCGC00169964-03
NCGC00169964-04
Cycloheximide (from Streptomyces griseus)
DB-054964
NS00127001
BRD-A62184259-001-01-0
BRD-A62184259-001-02-8
Q27163592
3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl] glutarimide
2,6-piperidinedione, 4-[2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-
2,6-Piperidinedione, 4-((2R)-2-((1R,3R,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-