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Razoxane

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Identification
Molecular formula
C11H16N4O4
CAS number
21416-68-6
IUPAC name
4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
State
State

Razoxane is typically in a solid state at room temperature.

Melting point (Celsius)
200.00
Melting point (Kelvin)
473.15
Boiling point (Celsius)
289.30
Boiling point (Kelvin)
562.45
General information
Molecular weight
268.27g/mol
Molar mass
268.2770g/mol
Density
1.5050g/cm3
Appearence

Razoxane typically appears as a white to off-white crystalline powder.

Comment on solubility

Solubility Overview of 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione

The solubility of the compound 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione can often be a pivotal factor in its applications. As a piperazine derivative, its solubility characteristics can be influenced by various environmental factors. Here are some key points to consider:

  • Polarity: Due to the presence of multiple functional groups, this compound may exhibit varying degrees of polarity, affecting its solubility in polar and nonpolar solvents.
  • Solvent Environment: The solubility is likely to be enhanced in aqueous solvents compared to nonpolar solvents, given its piperazine framework which is known for its ability to interact favorably with water.
  • Temperature Influence: Like many organic compounds, solubility could increase with rising temperatures, so it is essential to consider temperature when preparing solutions.
  • pH Dependence: As an organic compound, solubility is also expected to change with pH, particularly if the compound can exist in ionic forms in solution.

In summary, understanding the solubility of this compound is crucial for its utility in chemical reactions and biological applications. The combination of its structural elements contributes to its behavior in various environments, making it an intriguing subject for further study.

Interesting facts

Interesting Facts about 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione

This compound is a fascinating member of the piperazine family, recognized for its unique structure and potential therapeutic applications. It features a piperazine ring, which is a six-membered nitrogen-containing heterocycle, that is known for its ability to interact with various receptors in the human body.

Key Characteristics

  • Pharmacological Interest: Due to its structural components, this compound may exhibit properties beneficial for medicinal chemistry, particularly in the development of psychotropic agents.
  • Diverse Applications: Compounds with piperazine moieties are known to serve as intermediates in synthesizing numerous drugs, including antihistamines and antidepressants.
  • Structural Versatility: The presence of a dioxopiperazine unit suggests potential applications in drug design and discovery, enhancing the compound's effectiveness through various bioactive pathways.

Interestingly, research has shown that piperazine derivatives can enhance bioavailability and solubility, making them more effective as pharmaceutical agents. Such alterations can lead to decreased side effects while increasing therapeutic efficacy. As Dr. John D. Watson once stated, “The efficacy of a drug often lies in the details of its molecular structure.” This highlights the importance of studying compounds like 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione in the research laboratory.

Potential Research Directions

Scientists continue to explore the following areas related to this compound:

  • Mechanism of Action: Understanding how this compound interacts with receptors could illuminate pathways for disease treatment.
  • Analog Synthesis: Researchers are investigating variations in the compound's structure to enhance selectivity and reduce toxicity.
  • In Vivo Studies: Conducting studies on biological models to assess the efficacy and safety profile of the compound.

With its intriguing properties and potential for therapeutic advances, 4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione remains a compound of interest in contemporary medicinal chemistry research.

Synonyms
Razoxane
21416-67-1
ICRF-159
Razoxana
Razoxanum
ICRF 159
NSC-129943
ICI 59118
NSC129943
razoxano
NSC 129943
2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-
DTXSID0020733
CHEBI:50225
5AR83PR647
ICI-59118
DTXCID20733
ICRF 186
ICRF159
ICRF186
RefChem:178674
2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+-)-
244-379-2
4,4'-(Propane-1,2-diyl)bis(piperazine-2,6-dione)
Razoxin
4,4'-Propylenebis(piperazine-2,6-dione)
21416-87-5
4-[2-(3,5-dioxopiperazin-1-yl)propyl]piperazine-2,6-dione
MFCD00430424
4,4'-Propylenebis(2,6-piperazinedione)
MLS002920046
Tepirone
Troxozone
4,4'-propane-1,2-diyldipiperazine-2,6-dione
Razoxane (INN)
RAZOXANE [INN]
Razoxanum [INN-Latin]
Razoxana [INN-Spanish]
(+/-)-4,4'-Propylenedi-2,6-piperazinedione
Desrazoxane
(+)-dexrazoxane
dyzoxane
Eucardion
CCRIS 344
rac-Dexrazoxane
Cardioxane (TN)
NCI-C01627
NCGC00164737-01
EINECS 244-379-2
(+)-Razoxane
Propylenediazmintetraessigsaeure-diimid
(+)-Razoxin
BRN 0821182
Razoxane [INN:BAN]
(+)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
2,6-Piperazinedione, 4,4'-propylenedi-
2,6-Piperazinedione, 4,4'-propylenedi-, (+)-
1,2-Bis(3,5-dioxo-1-piperazinyl)propane
AI3-52845
Dexrazoxane Impurity 44
RAZOXANE [MI]
RAZOXANE [MART.]
2, 4,4'-propylenedi-
RAZOXANE [WHO-DD]
SCHEMBL9089
(+-)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
UNII-5AR83PR647
(+,-)-1,2-Bis(3,5-dioxopiperazine-1-yl)propane
Razoxane, >98% (HPLC)
CHEMBL444186
orb1305273
HMS3745O07
HMS5085E07
BCP17033
(+-)-1,5-dioxopiperazinyl)propane
Tox21_200258
2, 4,4'-propylenedi-, (+-)-
AKOS015837545
(.+-.)-1,5-dioxopiperazinyl)propane
AC-1422
NCGC00164737-02
NCGC00164737-03
NCGC00164737-04
NCGC00164737-05
NCGC00164737-06
NCGC00164737-07
NCGC00257812-01
2, 4,4'-propylenedi-, (.+-.)-
AS-67684
DA-57356
NCI60_000672
SMR001797645
1,2-bis(3,5-dioxopiperazin-1-yl)propane
CAS-21416-67-1
HY-119425
Propane,2-bis(3,5-dioxopiperazin-1-yl)-
(+-)-4.4'-Propylenedi-2,6-piperazindion
1,2-bis(3,5-dioxopiperazin-1-yl)-propane
CS-0068173
NS00005082
(+/-)-1,2-bis(3,5-dioxopiperazinyl)propane
C74037
D08471
F079510
(+/-)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane
Q3930720
(+-)-(3,3',5'-Tetraoxo)-1,2-dipiperazinopropane
.+-.-(3,3',5'-Tetraoxo)-1,2-dipiperazinopropane
2, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (+-)-
2, 4,4'-(1-methyl-1,2-ethanediyl)bis-, (.+-.)-