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Carvedilol

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Identification
Molecular formula
C24H26N2O3
CAS number
72956-09-3
IUPAC name
4-[2-(4-benzyl-1-piperidyl)-1-hydroxy-propyl]phenol
State
State

At room temperature, Carvedilol is found in a solid state as a powder. It is stable and does not readily form a liquid or gas under normal storage conditions. It is typically stored in airtight containers to maintain its solid form.

Melting point (Celsius)
114.00
Melting point (Kelvin)
387.15
Boiling point (Celsius)
692.30
Boiling point (Kelvin)
965.45
General information
Molecular weight
406.48g/mol
Molar mass
406.4850g/mol
Density
1.2037g/cm3
Appearence

Carvedilol appears as a white to almost white crystalline powder. It is sparingly soluble in methanol, slightly soluble in ethanol, and practically insoluble in water. Due to its crystalline nature, the powder can appear slightly reflective under certain lighting conditions.

Comment on solubility

Solubility of 4-[2-(4-benzyl-1-piperidyl)-1-hydroxy-propyl]phenol (C24H26N2O3)

When considering the solubility of 4-[2-(4-benzyl-1-piperidyl)-1-hydroxy-propyl]phenol, several factors come into play due to its unique chemical structure.

Key Factors Affecting Solubility

  • Hydroxyl Group: The presence of the –OH group enhances the potential for hydrogen bonding, contributing positively to solubility in polar solvents.
  • Aliphatic and Aromatic Components: The combination of aliphatic (propyl) and aromatic (phenol) characteristics can create a balance in solubility. The aromatic ring might limit solubility in highly polar solvents.
  • Presence of Nitrogen: The nitrogen atoms in the piperidine ring may introduce some degree of polarity, impacting how this compound interacts with various solvents.

Due to these structural features, it can be expected that:

  • This compound is likely to be soluble in organic solvents such as ethanol, methanol, or chloroform.
  • It may have limited solubility in water, reflecting the tendency of many organic compounds with significant hydrophobic character.

In conclusion, while 4-[2-(4-benzyl-1-piperidyl)-1-hydroxy-propyl]phenol may exhibit favorable solubility traits in certain organic solvents due to its functional groups, its overall solubility profile is a complex interplay of aromaticity and polarity.

Interesting facts

Facts About 4-[2-(4-benzyl-1-piperidyl)-1-hydroxy-propyl]phenol

This intriguing compound belongs to a class of chemicals known as phenolic compounds, which are characterized by the presence of a hydroxyl group (-OH) directly attached to an aromatic hydrocarbon group. Here are some interesting aspects of this compound:

  • Medicinal Potential: Compounds like this one, with a piperidine structure, are often studied for their biological activities. They may have potential therapeutic applications, particularly in the field of neurology and psychiatry.
  • Structure-Activity Relationship: The specific arrangement of functional groups in this compound can significantly influence its reactivity and binding affinity with biological targets. Scientists often use techniques like molecular docking to predict interactions with proteins.
  • Research Applications: Due to its unique structure, this compound could serve as a valuable reference in drug development and the synthesis of novel pharmacological agents.
  • Phenolic Compounds in Nature: Phenolic compounds are widely found in nature and are known for their antioxidant properties. The study of such compounds can lead to insights into their roles in plant defense mechanisms and health benefits in humans.

As we delve deeper into compounds like 4-[2-(4-benzyl-1-piperidyl)-1-hydroxy-propyl]phenol, we uncover the complex relationship between their structure and biological functions, paving the way for exciting discoveries in the field of medicinal chemistry. Their diversity and potential applications make them a significant area of study, bridging gaps between chemistry, biology, and pharmacology.

Synonyms
Ifenprodil
23210-56-2
ifenprodil tartrate
Dilvax
Vadilex
Creocral
IFENPRODIL HEMITARTRATE
4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol
Ifenprodilum
4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
RC 61-91
Ifenprodil [INN:DCF]
Ifenprodilum [INN-Latin]
Ifenprodil (tartrate)
UNII-R8OE3P6O5S
EINECS 245-491-4
R8OE3P6O5S
NP-120
Ifenprodil (INN)
1-Piperidineethanol, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-
23210-58-4
DTXSID2045656
RC-61-91
IFENPRODIL [MI]
IFENPRODIL [INN]
4-Benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-1-piperidineethanol
IFENPRODIL [WHO-DD]
2-(4-Benzylpiperidino)-1-(4-hydroxyphenyl)propanol
CHEMBL305187
DTXCID0025656
alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidine ethanol
NCGC00024643-03
1-Piperidineethanol, 4-benzyl-alpha-(p-hydroxyphenyl)-beta-methyl-
Ifenprodilum (INN-Latin)
(+/-)-Ifenprodil;RC 61-91
ifenprodil tartrate (1:1), (R-(R*,R*))-isomer
4-BENZYL-.ALPHA.-(P-HYDROXYPHENYL)-.BETA.-METHYL-1-PIPERIDINEETHANOL
CAS-23210-56-2
SR-01000075169
(+-)-ifenprodil
alpha-(4-Hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-1-piperidineethanol; (+/-)-Ifenprodil; 1-Methyl-2-hydroxy-2-(4-hydroxyphenyl)ethyl-1-(4-benzylpiperidine); 2-(4-Benzylpiperidino)-1-(1-hydroxyphenyl)-1-propanol; RC 61-91;
(plusmn)-ifenprodil
2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-2-methyl-1-ethanol
4-[2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol
SCHEMBL34010
()-Ifenprodil;RC 61-91
(+/-)-[2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)-1-propanol]
ChEMBL_104385
GTPL5472
CHEBI:93829
C04AX28
HMS2089G05
YAA21058
Tox21_110915
BDBM50083351
PDSP1_000654
PDSP2_000646
AKOS015895174
Tox21_110915_1
CCG-204747
DB08954
FI65042
SDCCGSBI-0050640.P003
1-Piperidineethanol, .alpha.-(4-hydroxyphenyl)-.beta.-methyl-4-(phenylmethyl)-
MRF-0000097
NCGC00024643-02
NCGC00024643-04
NCGC00024643-05
NCGC00024643-06
NCGC00024643-07
NCGC00024643-10
NCGC00024643-12
NCGC00024643-20
TS-07829
SBI-0050640.P002
4605A
NS00008388
D08064
EN300-18166867
L005364
Q5991156
SR-01000075169-1
SR-01000075169-3
BRD-A24191444-045-03-1
BRD-A24191444-045-10-6
BRD-A24191444-046-01-3
BRD-A24191444-046-02-1
BRD-A24191444-046-03-9
SR-01000075169-11
4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol
1-Piperidineethanol, alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenylmethyl)-(9CI)
136172-79-7
245-491-4
4-[2-(4-Benzyl-1-piperidyl)-1-hydroxy-propyl]phenol; (2R,3R)-2,3-dihydroxybutanedioic acid