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Pimobendan

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Identification
Molecular formula
C19H18N4O
CAS number
74150-27-9
IUPAC name
4-[2-(4-carbamimidoylphenyl)vinyl]benzamidine;2-hydroxyethanesulfonic acid
State
State

At room temperature, Pimobendan is in a solid state, occurring as a crystalline powder.

Melting point (Celsius)
218.00
Melting point (Kelvin)
491.15
Boiling point (Celsius)
275.00
Boiling point (Kelvin)
548.15
General information
Molecular weight
334.43g/mol
Molar mass
334.4320g/mol
Density
1.3500g/cm3
Appearence

Pimobendan is a white or off-white crystalline powder. It is practically insoluble in water, sparingly soluble in dichloromethane, and moderately soluble in ethanol.

Comment on solubility

Solubility Overview

The compound 4-[2-(4-carbamimidoylphenyl)vinyl]benzamidine;2-hydroxyethanesulfonic acid exhibits considerable nuances in its solubility profile due to its structural complexity. Solubility can significantly influence its behavior in various biochemical applications. Here’s a closer look:


Factors Affecting Solubility:

  • Polarity: The presence of both polar functional groups (e.g., sulfonic acid) and non-polar sections may lead to a balance in solubility in polar and organic solvents.
  • Hydrogen Bonding: The compound’s ability to engage in hydrogen bonding enhances its solubility in water, particularly in buffered solutions.
  • pH Sensitivity: Being a sulfonic acid derivative, solubility may vary significantly with changes in pH, leading to different solubility profiles in acidic versus neutral or basic conditions.

General Solubility Insights:

  • Water: Generally, acids and bases that can ionize tend to have improved solubility in water. Therefore, the sulfonic acid part of the compound likely promotes its solubility in aqueous environments.
  • Organic Solvents: While certain organic solvents could solubilize parts of the compound, the effectiveness would vary based on the solvent's polarity.
  • Concentration Effects: The solubility may also be concentration-dependent, where increased concentrations could lead to precipitation after surpassing saturation limits.

In conclusion, the solubility of 4-[2-(4-carbamimidoylphenyl)vinyl]benzamidine;2-hydroxyethanesulfonic acid is influenced by multiple interacting factors, making it essential to consider the specific conditions and environment in which it is used. As such, testing under desired conditions is advised for precise applications.

Interesting facts

Interesting Facts about 4-[2-(4-carbamimidoylphenyl)vinyl]benzamidine; 2-hydroxyethanesulfonic acid

This compound, a fascinating hybrid of amidine and sulfonic acid functionalities, showcases the intricate interplay between organic chemistry and biological applications. Here are some noteworthy aspects of this compound:

  • Dual Functionality: The presence of both an amidine group and a sulfonic acid moiety enhances the compound's potential for diverse biological interactions.
  • Potential Biological Role: Compounds with amidine groups are frequently studied for their roles as inhibitors in various enzyme systems, particularly in relation to protein arginine methyltransferases.
  • pH Stability: The inclusion of 2-hydroxyethanesulfonic acid is significant for maintaining a stable pH in biochemical experiments, which is crucial for optimal enzyme activity.
  • Drug Development: Due to its structural attributes, this compound holds promise in the field of drug discovery, particularly for therapeutic agents targeting cardiovascular and metabolic diseases.
  • Synthesis of Complex Molecules: Its synthesis may involve advanced techniques such as click chemistry, showcasing the innovative approaches chemists employ to construct complex organic molecules.

As chemists continue to explore this compound, it is likely to uncover new pathways for therapeutic intervention and broaden our understanding of molecular interactions in biological systems.