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Clotrimazole

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Identification
Molecular formula
C22H17Cl3N2O
CAS number
23593-75-1
IUPAC name
4-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-4H-imidazole
State
State

At room temperature, Clotrimazole is in a solid state, typically forming a powder used in numerous medical and pharmaceutical preparations.

Melting point (Celsius)
147.00
Melting point (Kelvin)
420.00
Boiling point (Celsius)
153.00
Boiling point (Kelvin)
426.00
General information
Molecular weight
344.85g/mol
Molar mass
344.8460g/mol
Density
1.2420g/cm3
Appearence

Clotrimazole is typically a white or slightly yellow crystalline powder. It is odorless and is primarily used in its solid form for pharmaceutical applications. It is often used in topical preparations like creams and ointments.

Comment on solubility

Solubility of 4-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-4H-imidazole

The solubility of 4-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-4H-imidazole is an important factor to consider when evaluating its applications and behavior in various environments. Generally, the solubility of a compound can be influenced by several key factors:

  • Polarity: This compound contains both hydrophobic (non-polar) and hydrophilic (polar) groups, suggesting that its solubility may vary significantly in different solvents.
  • Temperature: Like many solid compounds, its solubility may increase with temperature, making it more soluble in organic solvents or heated environments.
  • pH Dependence: Since 4H-imidazole derivatives can often behave as weak bases, changes in pH may affect ionization and thus alter solubility.
  • Solvent Effects: This compound is likely to have higher solubility in organic solvents (e.g., ethanol, dimethyl sulfoxide) compared to water due to its aromatic and aliphatic properties.

In summary, it can be generalized that:

  1. It may be more soluble in non-polar organic solvents than in water.
  2. Higher temperatures are likely to enhance its solubility.
  3. Adjusting the pH can provide insights into its solubility profile.

Understanding the solubility of this compound is crucial for its practical uses in pharmaceutical applications and chemical synthesis.

Interesting facts

Interesting Facts about 4-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-4H-imidazole

This fascinating compound belongs to a class of innovative structures that have broad implications in pharmaceutical science. Here are some noteworthy points to consider:

  • Mechanism of Action: Compounds like this one often demonstrate complex interactions at the molecular level, playing crucial roles as enzyme inhibitors, particularly in the realms of kinase and neurotransmitter receptors.
  • Pharmacological Potential: The presence of chlorinated aromatic groups suggests potential biological activity, possibly leading to applications in treating various diseases, including cancers and psychiatric conditions. This structural motif can enhance lipophilicity and, thus, bioavailability.
  • Leverage of Imidazole: The imidazole core is a notable feature in many medicinal compounds, renowned for its ability to form hydrogen bonds, which allows it to interact favorably with biological receptors.
  • Research Insight: The study of this compound may lead to a better understanding of structure-activity relationships (SAR), revealing how slight modifications can significantly impact therapeutic efficacy.
  • Environmental Considerations: Understanding the environmental impact and stability of chlorinated compounds is critical, as they may play a role in a range of ecological systems due to potential persistence and bioaccumulation.

As we delve deeper into the realm of such chemical compounds, we uncover not just their molecular intricacies but also their vast potential to revolutionize medical treatments and enhance our understanding of biochemical processes. Each step taken in research brings us closer to utilizing these unique structures for real-world applications.

Synonyms
68797-30-8
4-[2-[(4-chlorophenyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-4H-imidazole
4-{2-[(4-CHLOROPHENYL)METHOXY]-2-(2,4-DICHLOROPHENYL)ETHYL}-4H-IMIDAZOLE
SCHEMBL2350990
DTXSID50988506
LDIUYZDMWMDLDX-UHFFFAOYSA-N
NS00123099