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Gemifloxacin

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Identification
Molecular formula
C18H20F2N6O3S
CAS number
175463-14-6
IUPAC name
4-[[2-[5-amino-6-oxo-2-(2-thienyl)pyrimidin-1-yl]acetyl]amino]-2,2-difluoro-5-methyl-N-(2-morpholinoethyl)-3-oxo-hexanamide
State
State

At room temperature, Gemifloxacin is in solid form, typically supplied as tablets for pharmaceutical applications.

Melting point (Celsius)
256.50
Melting point (Kelvin)
529.65
Boiling point (Celsius)
555.20
Boiling point (Kelvin)
828.35
General information
Molecular weight
389.45g/mol
Molar mass
389.3620g/mol
Density
1.5000g/cm3
Appearence

Gemifloxacin appears as a white to pale yellow crystalline solid. It is typically seen in powder form and is practically insoluble in water.

Comment on solubility

Solubility of 4-[[2-[5-amino-6-oxo-2-(2-thienyl)pyrimidin-1-yl]acetyl]amino]-2,2-difluoro-5-methyl-N-(2-morpholinoethyl)-3-oxo-hexanamide

The solubility characteristics of the compound with the chemical formula C18H20F2N6O3S can be complex due to its intricate structure and functional groups. Here are some key points regarding its solubility:

  • Solvents:
    • This compound is likely to exhibit variable solubility in polar solvents such as water, ethanol, and methanol due to the presence of amino and carbonyl groups.
    • It may show better solubility in organic solvents like DMSO or acetonitrile, which can solvate large organic molecules effectively.
  • Polarity:
    • The presence of polar groups suggests that it could interact well with water molecules, enhancing solubility under certain conditions.
  • Temperature Influence:
    • It's essential to consider that solubility can vary with temperature; generally, an increase in temperature may improve solubility.
  • pH Dependency:
    • The solubility might also be pH-dependent, as changes in pH can affect the ionization of the amino groups.

In summary, the solubility of this complex compound is influenced by factors such as solvent choice, polarity, temperature, and pH. Understanding these factors is crucial for applications in pharmaceuticals and materials science, where solubility plays a vital role.

Interesting facts

Interesting Facts about 4-[[2-[5-amino-6-oxo-2-(2-thienyl)pyrimidin-1-yl]acetyl]amino]-2,2-difluoro-5-methyl-N-(2-morpholinoethyl)-3-oxo-hexanamide

This compound, often referred to within the scientific community for its intricately designed structure, embodies a fascinating intersection of organic chemistry and pharmacology. Here are some highlights that showcase its significance:

  • Pharmaceutical Potential: The compound possesses structural motifs that suggest potential biological activity, particularly as a therapeutic agent. Its incorporation of a pyrimidine ring hints at its possible role in inhibiting enzymes related to various diseases.
  • Fluorination Impact: With two fluorine atoms strategically placed in its structure, this compound may benefit from the enhanced metabolic stability typical of fluorinated organic molecules. Fluorine's unique properties can lead to improved pharmacokinetic profiles.
  • Targeted Design: The addition of a morpholinoethyl side chain may contribute to cellular permeability and target specificity, enhancing the compound's effectiveness while minimizing potential side effects.
  • Thienyl Group Influence: The presence of a thienyl moiety could allow for interesting interactions with biological targets, making it possible for this compound to exhibit unique electrophilic or nucleophilic reactivity.

Overall, the compound exemplifies the complexities and innovations in drug design, resulting from the interplay of multidisciplinary approaches in modern chemistry. As scientists continue to explore the vast potentials of such compounds, the future may unveil surprising therapeutic applications that benefit human health. As one prominent chemist noted, "Every molecule has a story; it's our job to decipher it."

Synonyms
2-[5-amino-6-oxo-2-(2-thienyl)-1,6-dihydropyrimidin-1-yl]-N-[3,3-difluoro-1-isopropyl-2-oxo-3-[N-(2-morpholinoethyl)carbamoyl]propyl]acetamide
SCHEMBL6132181
SZYHELVLDPKTOS-UHFFFAOYSA-N
PD193718