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Hydrocortisone hemisuccinate

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Identification
Molecular formula
C25H34O8
CAS number
2203-97-6
IUPAC name
4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic acid
State
State

At room temperature, hydrocortisone hemisuccinate is in a solid state. It is a crystalline powder known for its stability under dry conditions.

Melting point (Celsius)
215.00
Melting point (Kelvin)
488.15
Boiling point (Celsius)
459.15
Boiling point (Kelvin)
732.30
General information
Molecular weight
504.55g/mol
Molar mass
504.5540g/mol
Density
1.3500g/cm3
Appearence

Hydrocortisone hemisuccinate typically appears as a white to off-white crystalline powder. It is odorless and slightly hygroscopic, meaning it can absorb moisture from the air.

Comment on solubility

Solubility of 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic acid

This compound, known for its intricate structure, exhibits specific solubility characteristics that can significantly impact its usability in various applications. Understanding the solubility profile can be summarized through the following key points:

  • Polarity: Given the presence of hydroxyl (-OH) groups and oxo (-C=O) functionalities, the molecule is likely to possess a polar nature, suggesting a greater affinity for polar solvents.
  • Solvent Interaction: It is anticipated that the compound will demonstrate higher solubility in water and other polar solvents, such as ethanol or methanol, due to hydrogen bonding capabilities.
  • Temperature Dependence: Like many organic compounds, its solubility may increase with temperature, indicating that higher temperatures could enhance dissolution.
  • Potential Challenges: Depending on crystallization tendencies, there might be variations in solubility based on the solvent's temperature and purity.

In conclusion, while the compound's polar groups suggest a favorable solubility in polar solvents, practical experimentation is essential to determine the exact solubility metrics in a given solvent system. As a general rule, one should remember that "the solubility of a compound is akin to the chemistry of the interaction with the solvent it is placed in."

Interesting facts

Interesting Facts about 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic acid

This compound is a fascinating example of a complex steroid derivative with significant biological implications. Here are some intriguing aspects to consider:

  • Steroid Framework: This compound is rooted in a steroid structure, which is fundamental to many biological processes in living organisms. Steroids can function as hormones, signaling molecules, and play roles in various physiological functions.
  • Hydroxyl Groups: The presence of multiple hydroxyl groups in its structure indicates potential for various interactivity, making it suitable for diverse biochemical applications, especially in medicinal chemistry.
  • Applications: Compounds like this one are researched for their potential therapeutic uses, including anti-inflammatory properties, which can be pivotal in treating chronic diseases.
  • Stereochemistry: The compound's complex stereochemistry, characterized by specific configuration at several chiral centers, is crucial to its biological activity. The arrangement of atoms affects how the compound interacts with biological targets.
  • Research Interest: The unique structure has drawn the attention of many researchers, as understanding such compounds can lead to advances in drug development and synthetic biology.

As a multidimensional compound, 4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic acid is not just a chemical entity but a piece of a larger puzzle in the realms of biochemistry and pharmacology. As you dive deeper into its study, you will uncover the intricate balance between structure, function, and biological significance.

Synonyms
hydrocortisone hemisuccinate
2203-97-6
Hydrocortisone succinate
Cortisol succinate
Hydrocortisone 21-hemisuccinate
Hydrocortisone hydrogen succinate
Cortisol hemisuccinate
Aacicortisol
Aftasome
Oralsome
Saxizon
Hydrocortisone Roussel
ORISTAR HCSHS
Hydrocortisone Leurquin
CHEBI:31677
Hydroxycortisone succinate
NSC-7576
Hydrocortisone 21-succinate
Cortisol, hydrogen succinate
Hydrocortisone hemisuccinate anhydrous
IHV1VP592V
Hydrocortisonum Hemisuccinatum
Hydrocortisone succinate [JAN]
Cortisol 21-(hydrogen succinate)
Cortisol, 21-(hydrogen succinate)
EINECS 218-612-3
Hydrocortisone 21-(hydrogen succinate)
Hydrocortisone succinate (JP17)
11beta,17alpha,21-trihydroxypregn-4-ene-3,20-dione 21-succinate
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(hydrogensuccinate)
(11-beta)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypreg-4-ene-3,20-dione
Preg-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11-beta)-
HYDROCORTISONE HYDROGEN SUCCINATE [WHO-DD]
HYDROCORTISONE HYDROGEN SUCCINATE [EP MONOGRAPH]
Sopolkort
A-hyrocort
Sopolcort H
Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11.beta.)-
NSC-757049
HYDROCORTISONE HYDROGEN SUCCINATE (EP MONOGRAPH)
HYDROCORTISONE HEMISUCCINATE (USP-RS)
HYDROCORTISONE HEMISUCCINATE [USP-RS]
HYDROCORTISONE HYDROGEN SUCCINATE (MART.)
HYDROCORTISONE HYDROGEN SUCCINATE [MART.]
HYDROCORTISONE HEMISUCCINATE (USP MONOGRAPH)
HYDROCORTISONE HEMISUCCINATE [USP MONOGRAPH]
cortisol-21-(hydrogen succinate)
PREGN-4-ENE-3,20-DIONE, 21-(3-CARBOXY-1-OXOPROPOXY)-11,17-DIHYDROXY-, (11.BETA.)-, MONOHYDRATE
Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-, monohydrate
pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11beta)-
HYDROXYCORTISONE SUCCINATE [INCI]
11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(hydrogen succinate)
Cortisol 21-hemisuccinate
MLS000028530
MLS001146928
Solucortef
Pregn-4-ene-3,20-dione,21-(3-carboxy-1-oxopropoxy)-11,17-dihydroxy-, (11b)-
SMR000058328
4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoic acid
NCGC00022248-03
ST075193
Opera_ID_1732
hydrocortisone-hemisuccinate
CHEMBL977
UNII-IHV1VP592V
SCHEMBL7664
Lopac0_000623
MLS002207249
Hydrokortison-21-Hemisuccinat
4-((11,17-Dihydroxy-3,20-dioxopregn-4-en-21-yl)oxy)-4-oxobutanoic acid
HY-B1402R
DTXSID40872905
VWQWXZAWFPZJDA-CGVGKPPMSA-N
HMS2235G13
HMS3259A14
HY-B1402
BDBM50016931
LMST02030126
s5972
AKOS015969742
AC-6828
DB14545
FH44457
GS-6198
Hydrocortisone hemisuccinate (Standard)
NC00567
3-{[2-((1S,10S,11S,15S,17S,2R,14R)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyc lo[8.7.0.0<2,7>.0<11,15>]heptadec-6-en-14-yl)-2-oxoethyl]oxycarbonyl}propanoic acid
4-[2-[(8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxo-ethoxy]-4-oxo-butanoic acid
CS-0013125
NS00015393
EN300-55845
D01442
Hydrocortisone 21-hemisuccinate, analytical standard
Q27104202
Pregn-4-ene-3,20-dione, 21-(3-carboxy-1-oxopropoxy)-11, 17-dihydroxy-
(11beta)-21-(3-Carboxy-1-oxopropoxy)-11,17-dihydroxypregn-4-ene-3,20-dione
Hydrocortisone hydrogen succinate, British Pharmacopoeia (BP) Reference Standard
Hydrocortisone hydrogen succinate, European Pharmacopoeia (EP) Reference Standard
4-(2-((8S,9S,10R,11S,13S,14S,17R)-11,17-Dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethoxy)-4-oxobutanoic acid
4-{2-[(1R,3aS,3bS,9aR,9bS,10S,11aS)-1,10-dihydroxy-9a,11a-dimethyl-7-oxo-1H,2H,3H,3aH,3bH,4H,5H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]-2-oxoethoxy}-4-oxobutanoic acid
4-{2-[(1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-2,15-dimethyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-en-14-yl]-2-oxoethoxy}-4-oxobutanoic acid