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Flumetasone

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Identification
Molecular formula
C22H28F2O5
CAS number
2135-17-3
IUPAC name
4-[2-(9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid
State
State
Flumetasone is typically found as a solid at room temperature.
Melting point (Celsius)
250.00
Melting point (Kelvin)
523.15
Boiling point (Celsius)
241.00
Boiling point (Kelvin)
514.15
General information
Molecular weight
452.50g/mol
Molar mass
452.5000g/mol
Density
1.3841g/cm3
Appearence
Flumetasone typically appears as a white to off-white crystalline powder.
Comment on solubility

Solubility Profile

The compound 4-[2-(9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid exhibits a nuanced solubility behavior that can be influenced by several factors. Understanding its solubility is essential for various applications, particularly in pharmaceuticals and biochemical research.

Factors Affecting Solubility

The solubility of this complex compound can be impacted by various elements, including:

  • Polarity: The presence of functional groups, such as hydroxyl (–OH) and carbonyl (C=O), enhances the compound's polarity, often leading to increased solubility in polar solvents.
  • pH Levels: Changes in pH can affect the ionization of the acidic groups within the compound, significantly altering its solubility in aqueous environments.
  • Temperature: Generally, an increase in temperature can improve solubility due to increased molecular motion, allowing for more effective interactions with solvent molecules.

Solvent Compatibility

Based on theoretical predictions:

  • Aqueous Solutions: The compound may show varying degrees of solubility depending on the pH of the solution, with potential higher solubility in slightly basic conditions.
  • Organic Solvents: It might exhibit better solubility in polar organic solvents such as methanol, ethanol, or dimethyl sulfoxide (DMSO) due to its complex structure.

In conclusion, the solubility of 4-[2-(9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid is influenced by its structural characteristics and environmental conditions. Understanding these details is crucial for optimizing its use in various scientific applications.

Interesting facts

Interesting Facts About 4-[2-(9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid

This intriguing compound, often referred to by its abbreviated name in various scientific circles, is notably a part of the class of organic compounds known for their roles in pharmaceutical applications. Here are some fascinating insights into its chemistry and potential uses:

  • Pharmacological Potential: The complex structure of this compound suggests it may exhibit significant biological activity. Compounds similar to it have been investigated for their potential as antineoplastic agents, which are used in cancer treatment.
  • Fluorinated Features: The presence of a fluorine atom in the molecular structure enhances its ability to interact with biological systems, subsequently leading to increased potency and stability in medicinal chemistry.
  • Structural Complexity: Its intricate cyclopenta[a]phenanthren backbone is a characteristic of many natural steroid-like compounds; such structures often illuminate pathways for synthetic alterations that can enhance therapeutic efficacy.
  • Hydroxyl Groups: The dual hydroxy groups on the steroid framework may play crucial roles in the solubility and binding affinity of the compound, vital for its function within biological systems.
  • Oxidative Reactivity: The presence of multiple keto and hydroxy groups suggests that this compound might be involved in redox reactions, a feature that could be explored in development of antioxidants or therapeutics.

In conclusion, 4-[2-(9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl)-2-oxo-ethoxy]-4-oxo-butanoic acid is a compound rich in potential and mystery. Its elaborate structure serves as a reminder of the complexity found within organic chemistry and its vast applications in modern science.

Synonyms
AGN-PC-0JF3RG
23325-86-2
DTXSID40274940