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Norepinephrine

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Identification
Molecular formula
C8H11NO3
CAS number
51-41-2
IUPAC name
4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol
State
State

At room temperature, norepinephrine is usually in a solid state, most commonly found as a crystalline powder. It is often prepared in solution form for pharmacological applications.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
309.60
Boiling point (Kelvin)
582.75
General information
Molecular weight
169.18g/mol
Molar mass
169.1770g/mol
Density
1.2100g/cm3
Appearence

Norepinephrine typically appears as a colorless or white to off-white crystalline solid. However, in its pure form, it can absorb moisture and may turn brown upon exposure to air and light. It is sensitive to oxidation, therefore often stored in a dark, cool environment and sometimes in solution form for medical and research purposes.

Comment on solubility

Solubility of 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol (C8H11NO3)

The solubility of 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol is an intriguing characteristic influenced by its molecular structure. Due to its hydrophilic functional groups, this compound exhibits notable solubility behavior in various solvents.

Key Points on Solubility:

  • Hydrogen Bonding: The presence of hydroxyl (-OH) and amino (-NH2) groups allows for extensive hydrogen bonding with water molecules, enhancing its solubility in polar solvents.
  • Polar Nature: Given its polar nature, 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol is expected to be soluble in water, making it suitable for applications requiring aqueous mediums.
  • Solvent Compatibility: While highly soluble in polar solvents like water, it may exhibit limited solubility in nonpolar organic solvents due to a mismatch in polarity.

In summary, this compound demonstrates a strong affinity for solvents that can interact through hydrogen bonding, thus highlighting the importance of molecular interactions in solubility phenomena. As a general observation, compounds with similar functionalities tend to exhibit predictable solubility behavior when exposed to different environments.

Interesting facts

Interesting Facts about 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol

4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol, also known as a derivative of catecholamine, is a fascinating compound with several noteworthy characteristics:

  • Biological Significance: This compound plays a notable role in the biosynthesis of neurotransmitters. It is related to catecholamines, which include important neurotransmitters like dopamine, norepinephrine, and epinephrine.
  • Antioxidant Properties: The presence of the hydroxyl groups contributes to the compound's ability to act as an antioxidant, providing potential protective effects against oxidative stress in biological systems.
  • Potential Pharmacological Uses: Compounds with similar structures are being explored for their therapeutic potential, particularly in neuroscience and cardiology due to their modulating effects on neurotransmitter activity.
  • Structure-Activity Relationship: The presence of both amino and hydroxyl groups allows for a diverse range of interactions with biological targets, making it a candidate for further pharmacological studies.

The structural complexity of this compound makes it an interesting subject for research, especially in therealm of medicinal chemistry. With the ongoing investigation into its properties, scientists are expanding our understanding of how such compounds can influence human health. As one prominent chemist noted, "Understanding the nuances of molecular structure is key to unlocking new avenues in drug design." This highlights the importance of studying compounds like 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol for future advancements in medicine.

Synonyms
Nordefrin
Methylnoradrenaline
Isoadrenaline
Nordephrine
6539-57-7
4-(2-amino-1-hydroxypropyl)benzene-1,2-diol
Dioxynorepinephrine
Dihydroxyphenylpropanolamine
2-Amino-1-(3,4-dihydroxyphenyl)propan-1-ol
l-alpha-Methylnorepinephrine
(+-)-3,4-Dihydroxynorephedrine
alpha-Methylnorepinephrine
1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-
3,4-Dihydrophenyl-1-amino-2-propanol-1
CHEMBL764
CHEBI:81386
Dl-corbadrine
alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol
NORDEFRIN HYDROCHLORIDE
4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol
EINECS 229-452-9
1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-, [R-(R*,S*)]-
Spectrum_000972
BENZYL ALCOHOL, alpha-(1-AMINOETHYL)-3,4-DIHYDROXY-
l-a-Methylnorepinephrine
SpecPlus_000781
DL-a-Methylnorepinephrine
Prestwick0_000739
Prestwick1_000739
Prestwick2_000739
Spectrum2_001837
Spectrum3_001093
Spectrum4_001267
Spectrum5_001846
DL-alpha-Methylnorepinephrine
Oprea1_386938
BSPBio_002766
KBioGR_001854
KBioSS_001452
DivK1c_006877
SCHEMBL249722
SPBio_001913
SPBio_002637
Benzyl alcohol, .alpha.-(1-aminoethyl)-3,4-dihydroxy-
KBio1_001821
KBio2_001452
KBio2_004020
KBio2_006588
KBio3_001986
DTXSID10859546
(-)-3,4-Dihydroxy Norephedrine
HMS1570C20
(+/-)-3,4-Dihydroxynorephedrine
ALBB-023691
BDBM50027502
MFCD00008080
PDSP1_001113
PDSP2_001097
AKOS009158427
alpha-Methyl-(+)norepinephrine,(+/-)
alpha-Methyl-(-)norepinephrine,(+/-)
NCGC00015345-02
NCGC00015345-03
NCGC00094709-01
NCGC00094709-02
DA-56252
alpha-Methyl-(+/-)norepinephrine,(+/-)
DB-056673
NS00007824
C17925
4-(2-Amino-1-hydroxy-propyl)-benzene-1,2-diol
L000638
benzene, 1-(2-amino-1-hydroxy)propyl-3,4-dihydroxy-
Q27155324
((-))-.alpha.-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol