Interesting facts
Interesting Facts about 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol; hydrochloride
The compound 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol; hydrochloride, commonly known as carbidopa, plays a crucial role in modern medicine, particularly in the treatment of Parkinson's disease. It is primarily known for its ability to inhibit the enzyme aromatic L-amino acid decarboxylase. Here are some intriguing aspects of this compound:
- Mechanism of Action: Carbidopa works by preventing the conversion of levodopa to dopamine in the peripheral tissues, ensuring that more levodopa reaches the brain where it can be transformed into dopamine, a neurotransmitter essential for regulating movement.
- Combined Therapy: It's often used in combination with levodopa to enhance the treatment effects for patients suffering from Parkinson's disease. This duo is beneficial because it allows for a lower dose of levodopa to be used, minimizing potential side effects.
- Historical Context: The introduction of carbidopa into medical practice in the 1970s has significantly improved the quality of life for many Parkinson's patients, representing a landmark development in neurological therapy.
- Research Applications: Beyond its clinical use, carbidopa is also used in research settings to study the metabolism of dopamine and explore novel treatment pathways for various neurological disorders.
- Adverse Effects: Like many medications, it can have side effects, including nausea, dizziness, and dyskinesia, which are important to monitor in patients.
- Structural Insights: The presence of both amino and hydroxy functional groups contributes to the compound's reactivity and its ability to form interactions with biological targets, illustrating the significance of functional group chemistry in drug design.
This compound exemplifies the intersection of chemistry and medicine, showcasing how a thorough understanding of molecular interactions can lead to significant therapeutic advancements. As the pursuit for effective treatments continues, compounds like 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol; hydrochloride will remain at the forefront of pharmacological research.
Synonyms
Nordefrin hydrochloride
138-61-4
(-)3,4-Dihydroxynorephedrine
4-(2-amino-1-hydroxypropyl)benzene-1,2-diol;hydrochloride
Homoarterenol hydrochloride
Isoadrenaline hydrochloride
NORDEFRIN HYDROCHLORIDE
Norhomoepinephrine hydrochloride
EINECS 205-336-3
alpha-Methylnoradrenaline hydrochloride
Aminopropanol pyrocatechol hydrochloride
Homo arterenol hydrochloride
3,4-Dihydroxynorephedrine hydrochloride
3,4-Dihydroxyphenylaminopropanol hydrochloride
3,4-Dihydroxyphenylpropanolamine hydrochloride
Dihydroxyphenylaminopropanolhydrochlorid
alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl alcohol hydrochloride
2-(3,4-Dihydroxyphenyl)-2-hydroxy-1-methylethylammonium chloride
SCHEMBL316522
CHEMBL1612659
DTXSID80920974
YRJLEOWRVNBAOI-UHFFFAOYSA-N
CCG-39949
BENZYL ALCOHOL, alpha-(1-AMINOETHYL)-3,4-DIHYDROXY-, HYDROCHLORIDE
NCGC00095315-01
NCGC00095315-02
4-(2-Amino-1-hydroxypropyl)benzene-1,2-diol--hydrogen chloride (1/1)
1130-52-5
Solubility of 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol; hydrochloride
The solubility of 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol; hydrochloride is influenced by several factors that are critical for its application in various fields. This compound, being a hydrochloride salt, exhibits notable *solubility characteristics* which can be summarized as follows:
In practical terms, the *high solubility* of this compound in aqueous solutions makes it particularly useful in pharmaceutical formulations, where a readily dissolvable compound is critical for bioavailability.
To conclude, the solubility profile of 4-(2-amino-1-hydroxy-propyl)benzene-1,2-diol; hydrochloride is *generally favorable*, offering diverse possibilities across different applications.