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Sulfapyridine hydrochloride

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Identification
Molecular formula
C11H11N4O2S.HCl
CAS number
311-45-5
IUPAC name
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide;hydrochloride
State
State

At room temperature, sulfapyridine hydrochloride is typically in a solid state, presented as a crystalline powder. It tends to be stable under normal conditions and is used in various pharmaceutical preparations due to its antibacterial properties.

Melting point (Celsius)
190.00
Melting point (Kelvin)
463.15
Boiling point (Celsius)
262.00
Boiling point (Kelvin)
535.15
General information
Molecular weight
288.76g/mol
Molar mass
288.7620g/mol
Density
1.8000g/cm3
Appearence

Sulfapyridine hydrochloride generally appears as a white or slightly yellow crystalline powder. It is soluble in water due to the hydrochloride salt formation, which enhances its solubility compared to the free base.

Comment on solubility

Solubility of 4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide Hydrochloride

The solubility of 4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide; hydrochloride can be evaluated through several factors that influence its dissolution in various solvents. This compound, often encountered in pharmaceutical contexts, typically presents interesting solubility characteristics:

  • Solvent Dependence: The solubility varies significantly between polar and non-polar solvents. It tends to be more soluble in water compared to organic solvents due to its ionic nature.
  • Hydrochloride Form: The presence of the hydrochloride moiety generally enhances solubility in aqueous solutions, making it well-suited for formulations that require rapid absorption.
  • pH Sensitivity: The solubility of this compound is also pH-dependent. At lower pH values, it is expected to be more soluble due to protonation effects.

In a general statement, one could assert that "The solubility of this hydrochloride salt highlights its potential utility in biological applications, leveraging its favorable dissolution profile in physiological conditions."
Understanding these specific solubility parameters is key for optimizing drug formulation and enhancing therapeutic efficacy.

Interesting facts

Interesting Facts about 4-[(2-Aminopyrimidin-4-yl)amino]benzenesulfonamide; Hydrochloride

This compound, a derivative of sulfonamides, is a fascinating member of the class of substances known for their therapeutic applications, most notably as antimicrobials. Its structure features a sulfonamide group attached to an aromatic amine, which is common in many pharmaceutical agents.

Key Highlights:

  • Pharmacological Properties: Compounds like this have been explored for their potential in treating bacterial infections due to their ability to inhibit bacterial enzyme functions.
  • Synergy with Other Drugs: It has been noted that sulfonamides can exhibit synergistic effects when used in combination with other antibiotics, enhancing their overall efficacy.
  • Research Potential: This compound may offer a promising avenue in medicinal chemistry research, particularly in the design of new drugs targeting various biological pathways, including those involved in cancer treatments.
  • Mechanism of Action: Understanding this compound's mechanism can provide insights into how similar structures may be optimized for greater effectiveness and reduced side effects.

Furthermore, the presence of the aminopyrimidine moiety in the structure adds an interesting layer, as pyrimidine derivatives are of great interest in medicinal chemistry due to their broad range of biological activities. The integration of different functional groups can lead to compounds that are specifically tailored for targeted biological response.

In conclusion, the exploration of 4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide; hydrochloride not only highlights its present applications but also emphasizes the importance of understanding structure-activity relationships in the development of future therapeutic agents. As we continue to delve into this compound, one might say, "In the world of chemistry, every molecule tells a story, and every story opens a door to new possibilities."

Synonyms
22199-93-5
9V6OFB7KKZ
NSC-683526
UNII-9V6OFB7KKZ
4-(2-Amino-4-pyrimidylamino)benzenesulfonamide, hydrochloride
4-(2-AMINO-4-PYRIMIDYLAMINO)BENZENESULFONAMIDE HYDROCHLORIDE
Benzenesulfonamide, 4-((2-amino-4-pyrimidinyl)amino)-, hydrochloride (1:1)
RefChem:198556
4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonamide hydrochloride
MFCD00012784
4-((2-Aminopyrimidin-4-yl)amino)benzenesulfonamide hydrochloride
4-[(2-aminopyrimidin-4-yl)amino]benzenesulfonamide;hydrochloride
NSC683526
SCHEMBL6474750
AJQQWYVKGSZKFW-UHFFFAOYSA-N
XAA19993
AKOS008056284
CS-0239525
EN300-21442
G65192
Z104497306
4-[(2-Aminopyrimidin-4-yl)amino]benzene-1-sulfonamide HCl
4-(2-Aminopyrimidin-4-ylamino)benzenesulfonamide hydrochloride
4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonamidehydrochloride