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sulindac

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Identification
Molecular formula
C20H17ClO3S
CAS number
38194-50-2
IUPAC name
4-[2-(benzenesulfinyl)ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione
State
State
Solid at room temperature. Typically found as a crystalline powder suitable for tablet formulation.
Melting point (Celsius)
185.50
Melting point (Kelvin)
458.65
Boiling point (Celsius)
537.10
Boiling point (Kelvin)
810.25
General information
Molecular weight
356.87g/mol
Molar mass
356.4040g/mol
Density
1.4000g/cm3
Appearence

Sulindac is a yellow, crystalline solid that may exhibit a slight odor. It is typically available in the form of tablets for pharmaceutical use.

Comment on solubility

Solubility of 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione (C20H17ClO3S)

The solubility of 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione in various solvents can be both intriguing and complex due to its organic structure and functional groups. Here are some key points to consider:

  • Polar Solvents: The presence of sulfinyl groups may enhance solubility in polar solvents like water and methanol, but the degree is often contingent upon the overall molecular structure.
  • Non-Polar Solvents: Because of the large hydrophobic regions contributed by the phenyl groups, this compound is likely to dissolve well in non-polar solvents such as hexane or chloroform.
  • Temperature Influence: The solubility can be significantly affected by temperature, often increasing at elevated temperatures.
  • pH Sensitivity: The solubility may also vary with pH changes, especially if the compound can ionize or form different species under acidic or basic conditions.

In summary, while predicting the exact solubility of 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione requires experimental data, it can generally be expected to exhibit varying solubility behaviors based on the solvent characteristics and environmental conditions. Understanding these aspects not only aids in practical applications but also enhances our comprehension of the compound's potential interactions in various chemical contexts.

Interesting facts

Interesting Facts About 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione

This compound is a fascinating member of the pyrazolidine family, known for its unique structural properties and potential biological activities. Pyrazolidine-based compounds like this one have garnered attention in medicinal chemistry due to their ability to act as anti-inflammatory agents.

Key Features:

  • Structural Complexity: The compound contains multiple phenyl groups and a pyrazolidine backbone, which contributes to its versatility in chemical reactivity and potency.
  • Sulfinyl Group: The presence of the benzenesulfinyl moiety can enhance the compound's interaction with biological targets, serving as a crucial feature in its pharmacological activity.
  • Pharmacological Potential: Research suggests that compounds with similar structures may exhibit significant anti-inflammatory, analgesic, and anti-pyretic properties, making them valuable in pain management therapies.

Moreover, this compound's ability to inhibit certain enzymes could pave the way for further research into its role as a therapeutic agent. Scientists are continuously exploring its mechanism of action and potential applications, not only in treating inflammation but also in broader medical contexts.

As stated in a recent publication, "The exploration of pyrazolidine derivatives remains a promising frontier in drug discovery, offering novel therapeutic avenues for chronic conditions." This emphasizes the importance of such compounds in the ongoing quest for effective medications.

Overall, 4-[2-(benzenesulfinyl)ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione stands out as a compound of interest for both academics and pharmaceutical researchers due to its intricate structure and promising biological properties.

Synonyms
sulfinpyrazone
57-96-5
Sulphinpyrazone
Anturane
(+/-)-SULFINPYRAZONE
Sulfinpyrazon
Anturan
Diphenylpyrazone
Sulfoxyphenylpyrazolidine
Anturanil
Anturidin
Enturen
Anturano
1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)pyrazolidine-3,5-dione
USAF GE-13
Sulfinpirazona
Sulfinpyrazine
Sulfinpyrazonum
Anturen
Enturan
NSC 75925
4-[2-(benzenesulfinyl)ethyl]-1,2-diphenylpyrazolidine-3,5-dione
G 28315
Anturane (TN)
Sulfinpyrazonum [INN-Latin]
4-(Phenylsulfoxyethyl)-1,2-diphenyl-3,5-pyrazolidinedione
Sulfinpirazona [INN-Spanish]
1,2-Diphenyl-4-(2'-phenylsulfinethyl)-3,5-pyrazolidinedione
sufinpyrazone
suphinpyrazone
CHEBI:9342
HSDB 3396
1,2-Diphenyl-3,5-dioxo-4-(2-phenylsulfinylethyl)pyrazolidine
UNII-V6OFU47K3W
4-(2-Benzenesulfinylethyl)-1,2-diphenylpyrazolidine-3,5-dione
3,5-Pyrazolidinedione, 1,2-diphenyl-4-(2-(phenylsulfinyl)ethyl)-
EINECS 200-357-4
V6OFU47K3W
NSC-75925
BRN 0713597
DTXSID0023618
G 28,315
NSC75925
1,2-Diphenyl-4-(2-(phenylsulfinyl)ethyl)-3,5-pyrazolidinedione
G-28315
1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin
3,5-Pyrazolidinedione, 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-
Diphenylpyrazone;G-28315
DTXCID003618
1,2-Diphenyl-4-[2-(phenylsulfinyl)ethyl]-3,5-pyrazolidinedione
Sulfoxyphenylpyrazolidin
Sulfinpyrazone [USP:INN:BAN:JAN]
Apo-Sulfinpyrazone
CAS-57-96-5
NCGC00016255-01
1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]pyrazolidine-3,5-dione
Sulfinpyrazonum (INN-Latin)
Sulfinpirazona (INN-Spanish)
SULFINPYRAZONE (MART.)
SULFINPYRAZONE [MART.]
SULFINPYRAZONE (USP-RS)
SULFINPYRAZONE [USP-RS]
SULFINPYRAZONE (EP IMPURITY)
Sulfinpyrazone (USP:INN:BAN:JAN)
SULFINPYRAZONE [EP IMPURITY]
SULFINPYRAZONE (EP MONOGRAPH)
SULFINPYRAZONE (USP IMPURITY)
SULFINPYRAZONE [EP MONOGRAPH]
SULFINPYRAZONE [USP IMPURITY]
SMR000058991
sulfinpyrazone (SPZ)
SR-01000003152
sulfinpirazone
Prestwick_455
1,2-Diphenyl-3,5-dioxo-4-(2'-phenyl-sulfinyl-aethyl)-pyrazolidin [German]
MFCD00057279
Spectrum_001022
Prestwick0_000290
Prestwick1_000290
Prestwick2_000290
Prestwick3_000290
Spectrum2_001324
Spectrum3_000590
Spectrum4_000845
Spectrum5_000984
Sulfinpyrazone (Standard)
( inverted exclamation markA)-Sulfinpyrazone
SULFINPYRAZONE [MI]
SULFINPYRAZONE [INN]
SULFINPYRAZONE [JAN]
BIDD:PXR0096
SCHEMBL34421
BSPBio_000200
BSPBio_002040
KBioGR_001449
KBioSS_001502
MLS000028565
MLS001074941
DivK1c_000090
SPECTRUM1500554
SULFINPYRAZONE [VANDF]
SPBio_001447
SPBio_002419
BPBio1_000220
GTPL5826
Sulfinpyrazone (JAN/USP/INN)
SULFINPYRAZONE [WHO-DD]
HMS500E12
HY-B1271R
KBio1_000090
KBio2_001502
KBio2_004070
KBio2_006638
KBio3_001540
M04AB02
NINDS_000090
1,2-Diphenyl-4-(phenylsulfinylethyl)-3,5-pyrazolidinedione
HMS1568J22
HMS1921C09
HMS2092K11
HMS2095J22
HMS2233H11
HMS3259I06
HMS3371B22
HMS3712J22
HMS3885F12
Pharmakon1600-01500554
BCP05344
HY-B1271
SULFINPYRAZONE [ORANGE BOOK]
Sulfinpyrazone for system suitability
Tox21_110331
4-[2-(benzenesulfinyl)ethyl]-1,2-diphenyl-pyrazolidine-3,5-dione
BDBM50237626
CCG-39262
NSC757332
s4628
AKOS015913283
Tox21_110331_1
DB01138
DS-6609
NC00539
NSC-757332
IDI1_000090
(invertedexclamationmarkA)-Sulfinpyrazone
NCGC00016255-02
NCGC00016255-03
NCGC00016255-04
NCGC00016255-05
NCGC00016255-06
NCGC00016255-07
NCGC00016255-10
NCGC00018267-01
NCGC00023932-03
NCGC00023932-04
AC-13602
AC-32767
(+/-)-Sulfinpyrazone, analytical standard
SBI-0051528.P003
WLN: T5VNNV EHJ BR& CR& E2SO&R
DB-053135
AB00052103
CS-0013052
NS00004052
U0114
4-(Phenylsulfoxyethyl)-1,5-pyrazolidinedione
C07317
D00449
EN300-124005
H10364
3, 1,2-diphenyl-4-[2-(phenylsulfinyl)ethyl]-
AB00052103_13
Q3790542
SR-01000003152-2
SR-01000003152-4
BRD-A36217750-001-05-6
BRD-A36217750-001-09-8
BRD-A36217750-001-16-3
Z1557407327
Sulfinpyrazone, European Pharmacopoeia (EP) Reference Standard
1,2-di(phenyl)-4-(2-phenylsulfinylethyl)pyrazolidine-3,5-dione
1,2-diphenyl-4-[2-(phenylsulfinyl)-ethyl]-pyrazolidine-3,5-dione
Sulfinpyrazone, United States Pharmacopeia (USP) Reference Standard
Sulfinpyrazone for system suitability, European Pharmacopoeia (EP) Reference Standard
200-357-4