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Norepinephrine

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Identification
Molecular formula
C8H11NO3
CAS number
51-41-2
IUPAC name
4-[2-(butylamino)-1-hydroxy-ethyl]benzene-1,2-diol
State
State

At room temperature, norepinephrine is typically a solid. It is often encountered as a hydrochloride or another salt form, making it more stable for pharmaceutical use and research purposes.

Melting point (Celsius)
217.00
Melting point (Kelvin)
490.15
Boiling point (Celsius)
228.80
Boiling point (Kelvin)
501.95
General information
Molecular weight
169.18g/mol
Molar mass
169.1780g/mol
Density
1.2980g/cm3
Appearence

Norepinephrine appears as a white to off-white solid, often provided in its salt form which can appear more crystalline. In its pure form, it may appear as a faintly colored powder. It tends to darken upon exposure to air and light due to oxidation.

Comment on solubility

Solubility of 4-[2-(butylamino)-1-hydroxy-ethyl]benzene-1,2-diol

The solubility of 4-[2-(butylamino)-1-hydroxy-ethyl]benzene-1,2-diol, a compound with both hydrophilic and hydrophobic characteristics, can be quite intriguing. Understanding its solubility requires considering several factors:

  • Polarity: The presence of the hydroxyl groups (-OH) makes the compound more polar, which generally increases its ability to dissolve in polar solvents like water.
  • Hydrophobic interactions: Conversely, the butylamino side chain introduces hydrophobic characteristics, which may lead to decreased solubility in highly polar solvents.
  • Solvent selection: It is likely to exhibit better solubility in organic solvents, such as ethanol or dimethyl sulfoxide, due to its hydrophobic portions.
  • Hydrogen bonding: The ability to form hydrogen bonds with solvents can significantly affect solubility; this compound may engage in such interactions with water, enhancing its solubility.

In essence, the solubility of this complex compound can be described as:

  1. High in polar organic solvents.
  2. Moderate in water, depending on the structure's orientation and interactions with surrounding molecules.
  3. Limited in nonpolar solvents, due to the hydrophobic segments.

As a result, one can conclude that while this compound has the potential for notable solubility in various environments, its unique structure plays a crucial role in determining where it will dissolve best.

Interesting facts

Interesting Facts About 4-[2-(butylamino)-1-hydroxy-ethyl]benzene-1,2-diol

This chemical compound, also known as a type of phenolic compound, has several fascinating aspects worth exploring:

  • Biological Activity: Compounds similar to 4-[2-(butylamino)-1-hydroxy-ethyl]benzene-1,2-diol are known for their various biological activities. There's ongoing research into how structural variations can influence activities such as anti-inflammatory and antioxidant effects.
  • Pharmaceutical Relevance: Its structure suggests potential applications in drug development. Compounds with an amino group and hydroxyl functional groups are often found in pharmaceuticals, enhancing solubility and biological interactions.
  • Structural Significance: The presence of both hydroxyl (-OH) and amino (-NH₂) groups allows for interesting hydrogen bonding capabilities, making it a versatile compound in both synthetic and natural chemistry contexts.
  • Environmental Considerations: As with many chemical compounds, understanding its degradation pathways and environmental impact is critical. Compounds like this can play a role in both chemical synthesis and environmental chemistry.
  • Synthetic Pathways: The synthesis of 4-[2-(butylamino)-1-hydroxy-ethyl]benzene-1,2-diol involves intricate organic chemistry techniques, often showcasing strategies in functional group transformations and the use of protecting groups.

In summary, 4-[2-(butylamino)-1-hydroxy-ethyl]benzene-1,2-diol is not just a compound with a complex structure; it also serves a pivotal role in understanding biological processes, pharmaceutical development, and the intricate world of organic synthesis. As noted by researchers, "The interplay of functional groups offers a pathway to novel biological interactions and therapeutic modalities." This perspective emphasizes its significance beyond mere chemical existence.

Synonyms
3,4-Dihydroxy-alpha-(butylaminomethyl)benzyl alcohol
10253-82-4
Butyladrenaline
WIN 5590
BRN 2807791
Propyladrenalin
SN 4-151
Protocatechuyl alcohol, alpha-(butylaminomethyl)-
4-[2-(butylamino)-1-hydroxyethyl]benzene-1,2-diol
1,2-Benzenediol, 4-(2-(butylamino)-1-hydroxyethyl)-
alpha-((Butylamino)methyl)-3,4-dihydroxybenzyl alcohol
SCHEMBL9768153
SCHEMBL23727888
DTXSID80907689
BENZYL ALCOHOL, alpha-(BUTYLAMINOMETHYL)-3,4-DIHYDROXY-
1951-20-8