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Chloramphenicol base

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Identification
Molecular formula
C10H11Cl2NO2
CAS number
56-75-7
IUPAC name
[4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate
State
State
Solid at room temperature.

Typically stored in a dry place, away from light, to prevent degradation. Known to be slightly soluble in water but dissolves readily in alcohol and other organic solvents.

Melting point (Celsius)
150.00
Melting point (Kelvin)
423.15
Boiling point (Celsius)
380.00
Boiling point (Kelvin)
653.15
General information
Molecular weight
323.12g/mol
Molar mass
323.1400g/mol
Density
1.2400g/cm3
Appearence

Chloramphenicol base appears as a fine, white to off-white crystalline powder. It is often used for its antibiotic properties and is stable under ambient conditions. Typically, it should be stored away from excessive heat or moisture to maintain its integrity.

Comment on solubility

Solubility of [4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate

The solubility of the compound [4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate can be influenced by several important factors:

  • Polarity: Due to the presence of polar functional groups, such as the amino and chloroacetyl moieties, this compound is likely to exhibit moderate solubility in polar solvents like water.
  • Solvent Interaction: The solubility may also change in different organic solvents. Compounds with significant hydrogen bonding, such as this one, tend to be more soluble in solvents like methanol or ethanol.
  • Temperature Effects: Increasing the temperature can enhance solubility for many compounds. Therefore, examining the temperature dependence is crucial for understanding its solubility profile.

In summary, whilst [4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate exhibits varying solubility based on the influencing factors mentioned above, performing empirical solubility tests across various solvents will yield the most accurate insights. Observing solubility trends can also be beneficial, particularly when considering potential applications and reactivity in solution.

Interesting facts

Interesting Facts About [4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate

[4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate is a fascinating compound that plays a substantial role in the field of medicinal chemistry. Here are some noteworthy aspects:

  • Medicinal Applications: This compound is often investigated for its potential use in pharmaceuticals, particularly in the synthesis of various biologically active molecules.
  • Mechanism of Action: It functions as a precursor that can be transformed into other compounds, many of which exhibit significant antitumor and antimicrobial activities.
  • Chemical Structure: The presence of both chloroacetyl and amino groups in its structure contributes to its reactivity and ability to interact with various biological targets.
  • Importance of Haloalkanes: The chlorinated aspects of the compound play a key role in enhancing its electrophilicity, leading to increased reactivity in chemical reactions.
  • Research Interest: Researchers continue to study this compound not only for its specific applications but also as a model for understanding structure-activity relationships (SAR) in drug design.

As we delve deeper into the world of synthetic and medicinal chemistry, compounds like [4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate illuminate the path to understanding how chemical modifications can enhance biological properties.

In the words of a prominent chemist: “Every compound holds a story, waiting to unfold through meticulous research.” This quote perfectly encapsulates the ongoing fascination with chemical compounds like this one.

Overall, the study of [4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate not only deepens our understanding of drug development but also paves the way for innovative treatments in medicine.

Synonyms
17641-10-0
p-Chloroacetoxy-2-chloroacetanilide
BRN 2740116
2-Chloro-4'-chloroacetoxyacetanilide
Acetanilide, 2-chloro-4'-chloroacetoxy-
ACETANILIDE, 2-CHLORO-4'-HYDROXY-, CHLOROACETATE (ester)
DTXSID00170131
2-13-00-00247 (Beilstein Handbook Reference)
DTXCID9092622
[4-[(2-chloroacetyl)amino]phenyl] 2-chloroacetate
Chloroacetic acid 4-[(chloroacetyl)amino]phenyl ester
4-[(2-Chloroacetyl)amino]phenyl chloroacetate
MFCD01002194
AKOS015997806
4-(2-Chloroacetamido)phenyl 2-chloroacetate
[4-[(2-Chloroacetyl)amino]phenyl]2-chloroacetate