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Carvedilol

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Identification
Molecular formula
C24H26N2O4
CAS number
72956-09-3
IUPAC name
4-[2-(cyclohexylamino)-1-hydroxy-propyl]phenol
State
State

Carvedilol is a solid at room temperature and typically comes in a fine powder form.

Melting point (Celsius)
114.50
Melting point (Kelvin)
387.70
Boiling point (Celsius)
454.90
Boiling point (Kelvin)
728.10
General information
Molecular weight
406.49g/mol
Molar mass
406.4870g/mol
Density
1.0455g/cm3
Appearence

Carvedilol is a white to almost white crystalline powder.

Comment on solubility

Solubility of 4-[2-(cyclohexylamino)-1-hydroxy-propyl]phenol

The solubility of 4-[2-(cyclohexylamino)-1-hydroxy-propyl]phenol can be assessed based on its unique structural characteristics. This compound features both hydrophobic (cyclohexyl group) and hydrophilic (hydroxy and amino groups) components, which suggests an intriguing *balance* between solubility in various solvents.

Generally, the solubility can be influenced by:

  • Polarity of the solvent: Polar solvents, like water, may solubilize the hydrophilic parts of the molecule, whereas non-polar solvents may better solvate the cyclohexyl group.
  • Temperature: Higher temperatures typically increase solubility for many organic compounds, potentially affecting this compound as well.
  • pH levels: Since the compound has an amino group, its protonation state can affect its solubility in aqueous solutions, making it more soluble under certain pH conditions.

As a result, it can be expected that:

  • This compound is likely to have moderate solubility in polar organic solvents.
  • In water, the solubility may vary considerably depending on the pH due to the presence of ionizable functional groups.

In conclusion, while predicting precise solubility values can be complex, understanding the interplay of various factors provides valuable insights into the solubility behavior of 4-[2-(cyclohexylamino)-1-hydroxy-propyl]phenol.

Interesting facts

Interesting Facts about 4-[2-(Cyclohexylamino)-1-hydroxy-propyl]phenol

The compound 4-[2-(cyclohexylamino)-1-hydroxy-propyl]phenol, often referred to as a derivative of phenol, holds intriguing properties that pique the interest of chemists and pharmacologists alike. Here are some noteworthy aspects:

  • Pharmacological Interest: This compound is part of a larger class of compounds investigated for their potential therapeutic effects, particularly in the realm of anti-inflammatory and analgesic treatments.
  • Structural Significance: The presence of a cyclohexyl group offers enhanced lipophilicity, influencing its interaction with biological membranes and improving cellular uptake.
  • Hydroxy Group Role: The hydroxy group in the structure is crucial for hydrogen bonding, which can enhance solubility in certain environments and contribute to its biological activity.
  • Synthetic Pathways: The synthesis of this compound typically involves complex chemical reactions, often requiring specific catalysts to facilitate the transformation of starting materials into the desired product.

In conclusion, the dual role of both the cyclohexylamino group and the hydroxypropyl group contribute significantly to the behavior of this compound in biological systems, enhancing its relevance in medicinal chemistry research. Exploring compounds like 4-[2-(cyclohexylamino)-1-hydroxy-propyl]phenol opens up exciting possibilities for new therapeutic agents.

Synonyms
SMB 514
2207-83-2
1-(p-Hydroxyphenyl)-2-cyclohexylamino-propanol-1
alpha-(1-(Cyclohexylamino)ethyl)-p-hydroxy-benzyl alcohol
Benzenemethanol, alpha-(1-(cyclohexylamino)ethyl)-4-hydroxy-
BENZYL ALCOHOL, alpha-(1-(CYCLOHEXYLAMINO)ETHYL)-p-HYDROXY-
Benzenemethanol, alpha-(1-(cyclohexylamino)ethyl)-4-hydroxy-(9CI)
4-[2-(cyclohexylamino)-1-hydroxypropyl]phenol
DTXSID40944696