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Amiodarone

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Identification
Molecular formula
C25H29NO3
CAS number
1951-25-3
IUPAC name
[4-[2-(diethylamino)ethoxy]phenyl]-(2-ethylbenzofuran-3-yl)methanone
State
State

At room temperature, amiodarone is a solid.

Melting point (Celsius)
157.00
Melting point (Kelvin)
430.15
Boiling point (Celsius)
497.70
Boiling point (Kelvin)
770.85
General information
Molecular weight
645.32g/mol
Molar mass
645.3200g/mol
Density
1.2840g/cm3
Appearence

Amiodarone typically appears as a white crystalline powder. It may also have a slightly yellowish tint depending on purity and storage conditions. The powder is odorless.

Comment on solubility

Solubility Analysis

The compound [4-[2-(diethylamino)ethoxy]phenyl]-(2-ethylbenzofuran-3-yl)methanone exhibits interesting solubility characteristics due to its complex structure. Its solubility can be influenced by several factors, which include:

  • Polarity: The presence of the diethylamino group contributes to an increase in polarity, which may enhance its solubility in polar solvents like water.
  • Hydrophobic Regions: The ethylbenzofuran component introduces hydrophobic characteristics, potentially limiting solubility in highly polar solvents.
  • Solvent Compatibility: It is likely to show better solubility in organic solvents such as ethanol and dimethyl sulfoxide (DMSO), as these can interact favorably with relatively non-polar regions of the molecule.

Considering the balance between polar and non-polar functionalities, this compound may display a moderate solubility profile depending on solvent choice. It's essential to note that the solubility can also be affected by temperature and pH conditions, leading to variations in solubility behavior.

As a general guideline, it can be summarized that:

  • Higher solubility in polar solvents due to amino groups.
  • Moderate solubility in non-polar solvents due to hydrophobic components.

Overall, understanding solubility trends in compounds like this is critical for applications in pharmaceuticals, as it directly impacts bioavailability and therapeutic efficacy.

Interesting facts

Interesting Facts about [4-[2-(diethylamino)ethoxy]phenyl]-(2-ethylbenzofuran-3-yl)methanone

This intriguing chemical compound combines various functional groups that play crucial roles in its behavior and applications. Notably, it features both an ethoxy and a diethylamino group, which can significantly influence its reactivity and pharmacological properties.

  • Medicinal Potential: Compounds like this one have been studied for their potential pharmaceutical applications. The presence of the diethylamino group makes it a candidate for exploration in drug development.
  • Structure-Activity Relationship (SAR): Understanding how the different components of this compound interact can provide insights into its biological activity. Researchers often explore various analogs to optimize effectiveness.
  • Fluorescent Properties: The benzofuran moiety is known for its ability to fluoresce, leading to potential uses in optical applications, including sensors and fluorescent dyes.
  • Cross-disciplinary Applications: Beyond pharmaceuticals, compounds with similar structures have applications in materials science, such as organic light-emitting diodes (OLEDs) and dye-sensitized solar cells.

As researchers continue to investigate compounds like [4-[2-(diethylamino)ethoxy]phenyl]-(2-ethylbenzofuran-3-yl)methanone, the future may hold exciting discoveries that leverage its unique structure for innovative solutions in both health and technology. Understanding such compounds is vital in the continued quest for novel medicinal therapies and advanced materials.

Synonyms
Etabenzarone
15686-63-2
Etabenzarona
Etabenzarone [INN]
Etabenzaronum
Etabenzaronum [INN-Latin]
L 2642-Labaz
Etabenzarona [INN-Spanish]
L 2642
UNII-DA25635W9D
DA25635W9D
Benzofuran, 3-(p-(2-(diethylamino)ethoxy)benzoyl)-2-ethyl-
DTXSID70166147
p-(2-(Diethylamino)ethoxy)phenyl 2-ethyl-3-benzofuranyl ketone
p-(2-(Diethylamino)ethoxy)phenyl-2-ethyl-3-benzofuranyl ketone
L-2642
KETONE, p-(2-(DIETHYLAMINO)ETHOXY)PHENYL 2-ETHYL-3-BENZOFURANYL
Methanone, (4-(2-(diethylamino)ethoxy)phenyl)(2-ethyl-3-benzofuranyl)-
Etabenzaronum (INN-Latin)
Etabenzarona (INN-Spanish)
DTXCID4088638
Methanone, (4-(2-(diethylamino)ethoxy)phenyl)(2-ethyl-3-benzofuranyl)-(9CI)
[4-[2-(diethylamino)ethoxy]phenyl]-(2-ethyl-1-benzofuran-3-yl)methanone
SCHEMBL2108676
CHEMBL2106228
NS00125367
Q27276297