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Dopamine

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Identification
Molecular formula
C8H11NO2
CAS number
51-61-6
IUPAC name
4-[2-(dimethylamino)-1-hydroxy-ethyl]benzene-1,2-diol
State
State

At room temperature, dopamine is a solid in its pure form. However, for practical uses, especially in pharmaceutical applications, it is often stored in solution or as a salt form.

Melting point (Celsius)
128.00
Melting point (Kelvin)
401.15
Boiling point (Celsius)
545.00
Boiling point (Kelvin)
818.15
General information
Molecular weight
153.18g/mol
Molar mass
153.1810g/mol
Density
1.2600g/cm3
Appearence

Dopamine is a white to off-white crystalline powder. It is often available as a hydrochloride salt to maintain stability and solubility.

Comment on solubility

Solubility of 4-[2-(dimethylamino)-1-hydroxy-ethyl]benzene-1,2-diol

The solubility of 4-[2-(dimethylamino)-1-hydroxy-ethyl]benzene-1,2-diol is influenced by its chemical structure, particularly the presence of both hydrophilic and hydrophobic groups. This compound features a benzene ring with hydroxyl groups, which generally enhance solubility in polar solvents such as water.

Some key factors affecting its solubility include:

  • Hydroxyl (-OH) groups: The presence of multiple -OH groups on the benzene ring increases the capacity for hydrogen bonding with water molecules, thereby enhancing solubility.
  • Dimethylamino group: The dimethylamino moiety also contributes to the overall solubility due to its ability to interact with polar solvents.
  • Hydrophobic regions: The benzene ring adds a degree of hydrophobic character, which can limit solubility in non-polar solvents.

In general, while 4-[2-(dimethylamino)-1-hydroxy-ethyl]benzene-1,2-diol is likely to be soluble in polar solvents, its solubility can be significantly reduced in non-polar environments. As the old adage goes, "like dissolves like," and this holds true for this compound as well.

Overall, understanding the balance between hydrophilic and hydrophobic characteristics in chemical compounds is essential for predicting their solubility in various solvents.

Interesting facts

Insights into 4-[2-(dimethylamino)-1-hydroxy-ethyl]benzene-1,2-diol

This compound, often referred to in the context of various pharmacological applications, showcases a fascinating molecular structure that combines both aromatic and aliphatic components. Here are some engaging facts about 4-[2-(dimethylamino)-1-hydroxy-ethyl]benzene-1,2-diol:

  • Dual Functionality: The presence of both a benzene ring and an alcohol group means this compound can participate in both electrophilic substitution and hydrogen bonding reactions, making it versatile in synthetic applications.
  • Biological Relevance: Its structure includes a dimethylamino group, which is known to enhance biological activity by increasing lipophilicity and improving membrane permeability.
  • Potential Therapeutic Uses: Compounds with similar structures have been studied for their roles in pharmaceuticals, especially as potential agents in treating various diseases due to their ability to interact with biological receptors.
  • Synthetic Pathways: The synthesis of this compound provides insights into organic reaction mechanisms, particularly nucleophilic substitutions and the role of protecting groups in complex organic synthesis.
  • Analytical Techniques: To identify and characterize this compound, chemists often utilize advanced techniques like NMR spectroscopy and mass spectrometry, which can reveal underlying structural features.

In conclusion, 4-[2-(dimethylamino)-1-hydroxy-ethyl]benzene-1,2-diol not only emphasizes the rich connection between structure and function in chemistry but also opens doors to intriguing discussions about its applications in the field of medicinal chemistry. As one scholar famously stated, “In the world of chemistry, the smallest differences in structure can lead to the most significant variations in function.”

Synonyms
N-Methylepinephrine
Methadrene
N-Methyladrenaline
554-99-4
dl-N-Methylepinephrine
NSC 169812
EINECS 209-078-2
UNII-T12BO931W4
METHADREN(E)
T12BO931W4
alpha-(Dimethylaminomethyl)protocatechuyl alcohol
NSC-169812
alpha-(3,4-Dihydroxyphenyl)-beta-dimethylaminoethanol
Protocatechuyl alcohol, alpha-((dimethylamino)methyl)-
3,4-Dihydroxy-alpha-(dimethylaminomethyl) benzyl alcohol
3,4-Dihydroxy-alpha-(dimethylaminomethyl)benzyl alcohol
1,2-Benzenediol, 4-(2-(dimethylamino)-1-hydroxyethyl)-
alpha-(3,4-Dihydroxyphenyl)-alpha-hydroxy-beta-dimethylaminoethane
.alpha.-(Dimethylaminomethyl)protocatechuyl alcohol
.alpha.-(3,4-Dihydroxyphenyl)-.beta.-dimethylaminoethanol
1,2-Benzenediol, 4-[2-(dimethylamino)-1-hydroxyethyl]-
3,4-Dihydroxy-.alpha.-(dimethylaminomethyl)benzyl alcohol
N-METHYLEPINEPHRINE DL-FORM [MI]
BENZYL ALCOHOL, alpha-((DIMETHYLAMINO)METHYL)-3,4-DIHYDROXY-
.alpha.-(3,4-Dihydroxyphenyl)-.alpha.-hydroxy-(.beta.-dimethylamino)ethane
Protocatechuyl alcohol, .alpha.-((dimethylamino)methyl)-
Benzyl alcohol, .alpha.-((dimethylamino)methyl)-3,4-dihydroxy-
1,2-BENZENEDIOL, 4-(2-(DIMETHYLAMINO)-1-HYDROXYETHYL)-)
N-METHYLEPINEPHRINE DL-FORM
alpha((dimethylamino)methyl)-3,4-dihydroxybenzyl alcohol
1,2-Benzenediol, 4-(2-(dimethylamino)-1-hydroxyethyl)-(9CI)
alpha-(3,4-Dihydroxyphenyl)-alpha-hydroxy-(beta-dimethylamino)ethane
209-078-2
rlatyncitholtj-uhfffaoysa-n
4-[2-(dimethylamino)-1-hydroxyethyl]benzene-1,2-diol
4-[2-(DIMETHYLAMINO)-1-HYDROXYETHYL]PYROCATECHOL
4-(2-(Dimethylamino)-1-hydroxyethyl)pyrocatechol
rac N-Methyl Epinephrine
Benzyl alcohol,4-dihydroxy-
SCHEMBL521779
WLN: QR BQ DYQ1N1&1
DTXSID50871762
NSC169812
DB-228803
1, 4-[2-(dimethylamino)-1-hydroxyethyl]-
NS00044049
.alpha.-[(dimethylamino)methyl]protocatechuyl alcohol
4-(2-Dimethylamino-1-hydroxyethyl)benzene-1,2-diol
Q27289528
4-[2-(Dimethylamino)-1-hydroxyethyl]-1,2-benzenediol #
.alpha.-(3,4-Dihydroxyphenyl)-(.beta.-dimethylamino)ethanol
3,4-Dihydroxy-.alpha.-[(dimethylamino)methyl] benzyl alcohol
benzene, 1-(2-dimethylamino-1-hydroxy)ethyl-3,4-dihydroxy-