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Indoline-2-one derivative

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Identification
Molecular formula
C17H26N2O
CAS number
2217-46-7
IUPAC name
4-[2-(dipropylamino)ethyl]indolin-2-one
State
State
This compound is typically found as a solid at room temperature. It is stable under normal conditions and does not pose significant volatility issues.
Melting point (Celsius)
178.00
Melting point (Kelvin)
451.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
288.43g/mol
Molar mass
288.4280g/mol
Density
1.1537g/cm3
Appearence

This compound typically appears as a crystalline solid or powder. The precise color can vary from off-white to pale yellow depending on its purity and specific synthesis method used. Under normal conditions, it is stable and retains its solid form.

Comment on solubility

Solubility of 4-[2-(dipropylamino)ethyl]indolin-2-one

The solubility of the compound 4-[2-(dipropylamino)ethyl]indolin-2-one (C17H26N2O) is an intriguing factor that influences its applications in various fields. This compound, possessing both hydrophobic and hydrophilic characteristics, showcases a range of solubility behavior:

  • Solvent Compatibility: It is primarily soluble in organic solvents such as dimethyl sulfoxide (DMSO), ethanol, and methanol due to the presence of alkyl amine groups.
  • Limitations in Aqueous Solutions: The solubility in water is generally low, which can be attributed to the large hydrophobic indole ring and the long dipropylamino chains that hinder interactions with polar solvent molecules.
  • Temperature Influence: Solubility may increase with temperature, facilitating applications in drug formulations and chemical reactions where higher temperatures enhance dissolution.

In conclusion, the solubility profile of 4-[2-(dipropylamino)ethyl]indolin-2-one is essential for its effectiveness in chemical syntheses and biological contexts. When considering its use, one should meticulously evaluate the solvent system to optimize solvation characteristics.

Interesting facts

Interesting Facts about 4-[2-(dipropylamino)ethyl]indolin-2-one

The compound 4-[2-(dipropylamino)ethyl]indolin-2-one belongs to the class of indolinones, which are important in various fields of research and applications. Here are some fascinating insights into this compound:

  • Structural Significance: The indolinone structure is renowned for its versatile chemical properties and biological activities. The functional groups attached to the indole ring can significantly influence its reactivity.
  • Biological Activity: Compounds with indolinone structures have been investigated for their potential in medicinal chemistry, particularly as antidepressants, antipsychotics, and even as anti-cancer agents.
  • Role of Alkyl Amines: The dipropylamino group in this compound might enhance its lipophilicity and possibly lead to increased efficacy in biological systems by improving membrane penetration.
  • Research Applications: Scientists often explore compounds like this for drug design. The ability to modify the amino chain could lead to derivatives that target specific receptors in the body.
  • Synthetic Interest: The synthesis of compounds with indolinone frameworks often involves several interesting reactions, including cyclization and aromatic substitutions, showcasing the creativity of chemists.

A quote from renowned organic chemist Janet I. Van Horne emphasizes the significance of such compounds: "The diversity of indole derivatives in nature is a treasure trove for medicinal chemistry." This underlines the importance of 4-[2-(dipropylamino)ethyl]indolin-2-one as a potential lead compound in drug discovery.


In summary, the exploration of 4-[2-(dipropylamino)ethyl]indolin-2-one represents a blend of synthetic creativity and biological potential, making it an intriguing subject of study in modern chemistry.

Synonyms
ropinirole
91374-21-9
ropinirol
Ropinirolum
Ropinirolum [INN-Latin]
Ropinirol [INN-Spanish]
4-(2-(dipropylamino)ethyl)indolin-2-one
Ropitor
SKF 101468
SK&F 101468
4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one
Narapin
4-[2-(dipropylamino)ethyl]-1,3-dihydro-2H-indol-2-one
NSC-758917
CHEBI:8888
DTXSID8045195
UNII-030PYR8953
CHEMBL589
030PYR8953
DTXCID6025195
HSDB 8252
NSC 758917
SK&F-101468
NCGC00015893-02
Ropinirol (INN-Spanish)
Ropinirolum (INN-Latin)
4-(2-(Dipropylamino)ethyl)-1,3-dihydro-2H-indol-2-one
4-[2-(dipropylamino)ethyl]-2,3-dihydro-1h-indol-2-one
Ropitor (TN)
CAS-91374-21-9
Ropinirole [USAN:INN:BAN]
Ropinirolum (Latin)
ROPINIROLE [MI]
ROPINIROLE [INN]
Ropinirole (USAN/INN)
Lopac-R-4152
ROPINIROLE [USAN]
ROPINIROLE [VANDF]
ROPINIROLE [WHO-DD]
4-(2-(di-n-propylamino)ethyl)-2(3H)-indolone
Lopac0_001101
SCHEMBL35212
BIDD:GT0826
SPECTRUM1505178
GTPL7295
N04BC04
2H-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-
HMS2093K04
Pharmakon1600-01505178
BCP09383
HY-B0623
Tox21_110256
BDBM50020680
NSC758917
STL454344
AKOS015843123
Tox21_110256_1
CCG-205177
DB00268
FR32034
SB65618
SDCCGSBI-0051070.P002
SKF-101468
4-[2-(Dipropylamino)ethyl]2-indolinone
NCGC00015893-01
NCGC00015893-03
NCGC00015893-04
NCGC00015893-06
NCGC00094373-12
NCGC00096064-01
NCGC00096064-02
4-[2-(dipropylamino)ethyl]-3H-indol-2-ol
CS-0009561
NS00008049
C07564
D08489
EN300-708794
G78293
AB01563044_01
AB01563044_02
4-(2-dipropylaminoethyl)-1,3-dihydroindol-2-one
L000520
Q420590
SR-01000076215-3
BRD-K15933101-003-01-2
BRD-K15933101-003-06-1
BRD-K15933101-003-07-9
4-[2-(dipropylamino)ethyl]-1.3-dihydro-2H-indol-2-one