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Betaxolol

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Identification
Molecular formula
C18H29NO4
CAS number
63659-19-8
IUPAC name
[4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethyl-phenyl] acetate
State
State

At room temperature, betaxolol exists in a solid state. It typically comes as a crystalline powder, indicating good stability under normal conditions, which is typical for many pharmaceutical solids.

Melting point (Celsius)
165.00
Melting point (Kelvin)
438.15
Boiling point (Celsius)
440.00
Boiling point (Kelvin)
713.15
General information
Molecular weight
343.45g/mol
Molar mass
343.4530g/mol
Density
1.0800g/cm3
Appearence

Betaxolol hydrochloride appears as a white to off-white crystalline powder. It might slightly vary in shade and may also appear somewhat translucent depending on crystal composition. The compound is typically provided in its salt form, which enhances its solubility in water, but very little solubility in most organic solvents.

Comment on solubility

Solubility of [4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethyl-phenyl] acetate

The solubility of [4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethyl-phenyl] acetate in various solvents can be influenced by its chemical structure and functional groups. Understanding its solubility can provide insights into its potential applications and behavior in different environments.

Key Factors Affecting Solubility:

  • Polarity: The presence of hydroxyl (-OH) groups tends to increase solubility in polar solvents, while the hydrocarbon segments often favor non-polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds due to the hydroxyl group enhances solubility in water.
  • Chain Length: The isopropylamino moiety can alter the hydrophobic character, impacting its solubility profile.
  • Temperature: Generally, increasing temperature leads to increased solubility for many organic compounds.

In summary, while [4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethyl-phenyl] acetate may show greater solubility in polar solvents like water due to its hydroxyl group, its overall solubility will depend on several structural factors and the specific solvent environment. To fully explore its solubility characteristics, experimental investigation is recommended.

Interesting facts

Interesting Facts About 4-[2-Hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethyl-phenyl Acetate

This intriguing compound, known for its diverse applications, showcases the fascinating intersection of organic chemistry and pharmacology. Here are some notable aspects of this chemical:

  • Pharmacological Importance: This compound is a derivative commonly investigated for its potential use in medicinal chemistry. Its structure suggests possible activity as a pharmaceutical agent, particularly in the treatment of various conditions due to the presence of the isopropylamino group, known to enhance biological activity.
  • Structural Significance: The presence of both hydroxy and acetate functional groups in the structure contributes to its unique reactivity and interactions. This structural complexity enhances its oxidative stability which is beneficial in various applications.
  • Synthetic Versatility: The synthesis of this compound involves multi-step procedures, often including nucleophilic substitutions and esterification. This highlights the compound's importance in organic synthesis and the investigation of new synthetic methods.
  • Research Applications: Beyond medicinal uses, compounds similar to this are used in research to study enzyme interactions, cellular processes, and drug development pathways. They often serve as model compounds in biological studies due to their well-defined structures.

In summary, 4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethyl-phenyl acetate is not just a chemical entity, but a key player in the realms of medicinal chemistry and organic synthesis, providing rich ground for research and discovery. Its intriguing properties and versatility make it a compound worthy of further exploration.

Synonyms
Metipranolol
22664-55-7
Trimepranol
Metipranololum
VUAB-6453
VUAB6453
DTXSID4046078
X39AL81KEB
(+-)-metipranolol
CHEBI:6897
BM-01004
BM01.004
Phenol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2,3,6-trimethyl-, 1-acetate
BM-01.004
Methypranol
DTXCID2026078
4-{2-hydroxy-3-[(propan-2-yl)amino]propoxy}-2,3,6-trimethylphenyl acetate
Acetic acid 4-(2-hydroxy-3-isopropylamino-propoxy)-2,3,6-trimethyl-phenyl ester
Phenol, 4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]-2,3,6-trimethyl-, 1-acetate
metipranololo
Glauline
4-(2-hydroxy-3-((propan-2-yl)amino)propoxy)-2,3,6-trimethylphenyl acetate
1-(4-Acetoxy-2,3,5-Trimethylphenoxy)-3-Isopropylamino-2-Propanol
RefChem:925824
GlyTouCan:G27369LA
S01ED04
G27369LA
245-151-5
Disorat
Metipranololum [INN-Latin]
D,l-metipranolol
[4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl] acetate
VUAB6453 (SPOFA)
Turoptin
NCGC00159498-02
VUFB-6453
EINECS 245-151-5
Metipranolol (USAN/INN)
UNII-X39AL81KEB
BRN 2152010
Metipranolol [USAN:INN:BAN]
(RS)-4-(2-Hydroxy-3-isopropylaminopropoxy)-2,3,6-trimethylphenyl acetat
1-(4-Hydroxy-2,3,5-trimethylphenoxy)-3-(isopropylamino)-2-propanol 4-acetate
4-(2-Hydroxy-3-((1-methylethyl)-amino)propoxy)-2,3,6-trimethylphenol 1-acetate
(+-)-1-(4-Hydroxy-2,3,5-trimethylphenoxy)-3-(isopropylamino)-2-propanol 4-acetate
(+/-)-metipranolol
Metipranolol (Standard)
METIPRANOLOL [MI]
METIPRANOLOL [INN]
METIPRANOLOL [USAN]
2-Propanol, 1-(4-hydroxy-2,3,5-trimethylphenoxy)-3-(isopropylamino)-, 4-acetate
CHEMBL1291
METIPRANOLOL [VANDF]
SCHEMBL24324
METIPRANOLOL [MART.]
METIPRANOLOL [WHO-DD]
GTPL7239
orb1685343
SCHEMBL29962877
HMS5087K06
EX-A4499
Tox21_111719
MFCD00864567
[4-[2-hydroxy-3-(isopropylamino)propoxy]-2,3,6-trimethyl-phenyl] acetate
AKOS015995599
DB01214
HY-121567R
Phenol, 4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-2,3,6-trimethyl-, (+-)-, 1-acetate
NCGC00159498-03
DA-75513
MS-24496
CAS-22664-55-7
HY-121567
CS-0082752
NS00004058
C07915
D02374
G12675
SBI-0654196.0001
EN300-18563025
L001291
SR-01000883679
Q6593346
SR-01000883679-1
BRD-A99388803-001-01-5
1-(2,3,5-trimethyl-4-acetoxyphenoxy)-3-isopropylamino-2-propanol
4-(2-hydroxy-3-(isopropylamino)propoxy)-2,3,6-trimethylphenyl acetate
4-[2-hydroxy-3-(propan-2-ylamino)propoxy]-2,3,6-trimethylphenyl acetate
(+/-)-1-(4-HYDROXY-2,3,5-TRIMETHYLPHENOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL 4-ACETATE
PHENOL, 4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)-2,3,6-TRIMETHYL-, (+/-)-, 1-ACETATE