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Fumaric acid monoethyl ester

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Identification
Molecular formula
C6H8O5
CAS number
623-91-6
IUPAC name
4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid
State
State

At room temperature, fumaric acid monoethyl ester is typically a solid with a crystalline structure. It remains stable under normal conditions and does not readily vaporize due to its relatively low volatility.

Melting point (Celsius)
208.00
Melting point (Kelvin)
481.15
Boiling point (Celsius)
480.00
Boiling point (Kelvin)
753.15
General information
Molecular weight
174.13g/mol
Molar mass
174.1500g/mol
Density
1.2530g/cm3
Appearence

Fumaric acid monoethyl ester appears as a white solid or crystalline powder. It is soluble in water and organic solvents like ethanol and acetone, and has a faint characteristic odor.

Comment on solubility

Solubility of 4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid

The solubility of 4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid can be influenced by several factors, such as temperature and the presence of solvents. Generally, this compound tends to exhibit the following characteristics:

  • Polarity: Due to its hydroxy and carbonyl groups, the molecule has a significant polar character, which typically enhances its solubility in polar solvents.
  • Solvent Compatibility: It is expected to be more soluble in water and alcohols than in nonpolar solvents like hexane. This behavior is attributed to the hydrogen bonding capabilities of the hydroxyl group.
  • Temperature Effects: Like many organic acids, an increase in temperature often leads to increased solubility, as higher temperatures can disrupt intermolecular interactions.

Additionally, the compound's ability to form hydrogen bonds could further promote solubility in aqueous environments. The phrase "like dissolves like" often applies here, as its polar nature aligns with similar solvent properties, enhancing its dissolving capacity.

In summary, the solubility of 4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid is favorable in polar solvents, particularly water, making it versatile for various chemical applications.

Interesting facts

Interesting Facts about 4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid

4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid is a fascinating compound that plays a noteworthy role in various chemical applications. Here are some intriguing insights:

  • Versatile Building Block: This compound serves as a key intermediate in the synthesis of various pharmaceuticals and agrochemical products. Its unique structure allows it to participate in diverse chemical reactions, making it a valuable starting point for complex molecule construction.
  • Hydroxyl Group Influence: The presence of a hydroxyl group in its structure enhances the compound's reactivity. This functional group can significantly influence interaction with other chemical systems, often leading to improved solubility and bioavailability in medicinal chemistry.
  • Biological Significance: Some derivatives of this compound have been studied for their potential biological activities. Researchers are particularly interested in their anti-inflammatory and antimicrobial properties, which can lead to the development of new therapeutic agents.
  • Eco-friendly Potential: With increased focus on sustainability, compounds like 4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid are being explored for use in green chemistry applications. This includes potential use in the development of biodegradable materials and environmentally friendly solvents.
  • Research Interest: The compound has attracted attention in organic synthesis and medicinal chemistry fields, prompting ongoing studies aimed at optimizing its properties and understanding its reactivity, paving the way for innovative applications.

In summary, 4-(2-hydroxyethoxy)-4-oxo-but-2-enoic acid symbolizes the intersection of creativity and functionality in the world of chemistry. As research advances, new discoveries about its capabilities are likely to unfold, further enhancing its significance in both industrial and academic settings.

Synonyms
4-(2-hydroxyethoxy)-4-oxobut-2-enoic acid
SCHEMBL216330
SCHEMBL26125596
DTXSID801303869
37916-19-1