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1-(3,4,5-Trimethoxybenzoyl)-4-(o-methoxyphenyl)piperazine

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Identification
Molecular formula
C21H26N2O5
CAS number
69187-63-3
IUPAC name
[4-(2-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
State
State

At room temperature, the compound is in a solid state. This is due to its complex molecular structure, which gives it a relatively high melting point compared to simpler organic molecules.

Melting point (Celsius)
117.00
Melting point (Kelvin)
390.15
Boiling point (Celsius)
409.00
Boiling point (Kelvin)
682.15
General information
Molecular weight
372.44g/mol
Molar mass
372.4170g/mol
Density
1.2179g/cm3
Appearence

The compound is typically a solid at room temperature and appears as a white to off-white crystalline powder. Its crystalline structure can contribute to its distinctive appearance among other organic compounds.

Comment on solubility

Solubility Overview

The solubility of [4-(2-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone is influenced by its unique molecular structure and the presence of various functional groups. Understanding its solubility properties can be critical for applications in pharmaceuticals and organic chemistry.

Factors Affecting Solubility

Several factors can dictate the solubility of this compound:

  • Polarity: The presence of methoxy groups contributes to the overall polarity of the molecule, which can affect its interaction with solvents.
  • Hydrogen Bonding: Functional groups such as methoxy can engage in hydrogen bonding, potentially enhancing solubility in polar solvents.
  • Hydrophobic Interactions: The piperazine and phenyl groups may induce hydrophobic characteristics, influencing solubility in non-polar solvents.

Solvent Compatibility

This compound is likely to exhibit variable solubility depending on the solvent used:

  • Polar solvents: May enhance solubility due to the interaction between the methoxy groups and the solvent.
  • Non-polar solvents: Solubility might be lower due to hydrophobic interactions.

General Remarks

In conclusion, while the solubility of [4-(2-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone can be complex, it's crucial to determine the specific solubility characteristics in the solvent systems that you might employ for experiments or synthesis. Careful analysis and experimentation will shed more light on its solubility behavior.

Interesting facts

Interesting Facts about [4-(2-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone

This compound represents a fascinating blend of organic chemistry and medicinal potential. It falls under the category of piperazine derivatives, which are known for their diverse biological activities. Here are some key insights:

  • Structural Diversity: The compound features a piperazine ring, which is a common scaffold in many pharmaceutical agents, enabling various substituents that can modify its activity.
  • Potential Pharmacological Uses: Due to the presence of the methoxy groups and the piperazine moiety, this compound may exhibit properties that can be explored for neuropharmacological effects, potentially acting as a ligand for serotonin receptors.
  • Research Significance: Compounds of this nature are often studied in drug discovery for their potential in treating conditions such as depression, anxiety, and other mood disorders.
  • Galaxy of Functional Groups: The multiple methoxy substituents on the phenyl groups can affect the compound's lipophilicity and pharmacokinetic profiles, making it a subject of interest in medicinal chemistry.

As a chemistry student or researcher, understanding such compounds embraces the intersection of structure and activity. By investigating the various properties of [4-(2-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone, scientists can further explore its mechanisms and therapeutic potentials. The journey of one such compound from synthesis to therapeutic application showcases the vibrant world of drug discovery!

Synonyms
17766-68-6
4-(o-Methoxyphenyl)piperazinyl 3,4,5-trimethoxyphenyl ketone
KETONE, 4-(o-METHOXYPHENYL)PIPERAZINYL 3,4,5-TRIMETHOXYPHENYL
1-(2-methoxyphenyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
[4-(2-methoxyphenyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
BRN 1605432
1-(o-Methoxyphenyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
Piperazine, 1-(o-methoxyphenyl)-4-(3,4,5-trimethoxybenzoyl)-
Cambridge id 5286049
Oprea1_537028
Oprea1_757375
5-23-02-00004 (Beilstein Handbook Reference)
SCHEMBL1219349
DTXSID30170361
STK058409
AKOS003270421
ST055458
AB00079290-01
AG-690/36932017
SR-01000470504
SR-01000470504-1
Z27737341
4-(2-methoxyphenyl)piperazinyl 3,4,5-trimethoxyphenyl ketone
[4-(2-methoxyphenyl)piperazin-1-yl](3,4,5-trimethoxyphenyl)methanone