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Fentanyl phosphate

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Identification
Molecular formula
C28H36N2O4P
CAS number
105603-40-1
IUPAC name
4-[2-phenyl-3-(4-piperidyl)propyl]piperidine;phosphoric acid
State
State

At room temperature, fentanyl phosphate is typically in a solid state.

Melting point (Celsius)
87.50
Melting point (Kelvin)
360.65
Boiling point (Celsius)
220.00
Boiling point (Kelvin)
493.15
General information
Molecular weight
428.52g/mol
Molar mass
428.5210g/mol
Density
1.1056g/cm3
Appearence

Fentanyl phosphate is a white to off-white crystalline powder.

Comment on solubility

Solubility of 4-[2-phenyl-3-(4-piperidyl)propyl]piperidine;phosphoric acid

The solubility of 4-[2-phenyl-3-(4-piperidyl)propyl]piperidine;phosphoric acid can be influenced by several factors, primarily due to its complex molecular structure. Understanding these factors can help illuminate its aqueous and organic solvent solubility.

Key Points About Solubility:

  • Aqueous Solubility: Compounds containing phosphoric acid groups often exhibit higher solubility in water compared to their non-acidic counterparts, owing to the ionic interactions with water molecules.
  • Organic Solubility: The presence of aromatic rings and a piperidine structure generally suggests better solubility in organic solvents, including ethanol and dimethyl sulfoxide (DMSO).
  • Ionization: The protonation state of the phosphoric acid moiety can significantly influence solubility. In a protonated form, it may engage in stronger intermolecular interactions with polar solvents.
  • Temperature Effects: Increased temperature typically enhances solubility for many compounds as it can promote better molecular interactions and decrease lattice energy.

In summary, while the presence of phosphoric acid typically suggests favorable water solubility, the overall solubility behavior of 4-[2-phenyl-3-(4-piperidyl)propyl]piperidine;phosphoric acid requires careful consideration of both environmental and chemical factors. It is always beneficial to perform empirical solubility tests under various conditions to determine practical solubility attributes.

Interesting facts

Interesting Facts about 4-[2-phenyl-3-(4-piperidyl)propyl]piperidine;phosphoric acid

The compound 4-[2-phenyl-3-(4-piperidyl)propyl]piperidine;phosphoric acid is an intriguing molecule that boasts several interesting characteristics and applications:

  • Pharmaceutical Potential: This compound is significant in medicinal chemistry. Its intricate structure suggests potential use in drug design, particularly for neurological disorders due to the presence of piperidine rings that can influence neurotransmitter receptors.
  • Structural Complexity: The molecule is a combination of a phenyl group and two piperidine moieties. Such chemical diversity is often linked to enhanced biological activity, making it a topic of interest for synthetic chemists.
  • Role in Research: Researchers utilize this compound to investigate its receptor-binding affinities, which can lead to breakthroughs in understanding and treating conditions like anxiety and depression.
  • Interaction with Phosphoric Acid: The presence of phosphoric acid in its formulation not only enhances solubility but may also facilitate biological activity, furthering its application in pharmacology.

As emphasized by chemists, "The journey from compound design to therapeutic application is as fascinating as the compounds themselves." This highlights the importance of such compounds in bridging the gap between chemistry and practical medical applications.

In summary, 4-[2-phenyl-3-(4-piperidyl)propyl]piperidine;phosphoric acid exemplifies the fusion of complex chemical structures with significant potential in the pharmaceutical landscape, making it a compelling subject of study in contemporary chemistry.

Synonyms
1,3-DI(4-PIPERIDYL)-2-PHENYLPROPANE DIPHOSPHATE
708YF76EZI
5498-01-1
Piperidine, 4,4'-(2-phenyltrimethylene)di-, phosphate (1:2)
AC1L2ITJ
UNII-708YF76EZI
DTXSID30274712