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TFMPP

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Identification
Molecular formula
C18H21N3O4
CAS number
15532-75-9
IUPAC name
[4-(2-pyridyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone
State
State

At room temperature, TFMPP is in a solid state.

Melting point (Celsius)
127.00
Melting point (Kelvin)
400.15
Boiling point (Celsius)
485.10
Boiling point (Kelvin)
758.25
General information
Molecular weight
318.37g/mol
Molar mass
318.3710g/mol
Density
1.2290g/cm3
Appearence

TFMPP typically appears as a crystalline powder.

Comment on solubility

Solubility of [4-(2-pyridyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone

The solubility profile of [4-(2-pyridyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone is quite intriguing and varies depending on several factors such as temperature, pH, and the presence of other solutes. This compound, characterized by its complex structure, exhibits notable solubility behavior:

  • General Solubility: It is typically moderately soluble in polar solvents like water and dimethyl sulfoxide (DMSO) due to the presence of functional groups that can engage in hydrogen bonding and dipole-dipole interactions.
  • Aromatic Nature: The presence of multiple methoxy groups may enhance solubility in organic solvents such as ethanol and methanol, which can effectively solvate the hydrophobic regions of the molecule.
  • Effects of pH: The piperazine moiety can be protonated in acidic conditions, potentially increasing solubility in aqueous environments, making it more favorable for pharmaceutical applications.
  • Temperature Influence: Increasing temperature typically enhances solubility for many organic compounds, which may also apply to this compound, leading to better dissolution rates in higher temperatures.

Overall, understanding the solubility of [4-(2-pyridyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone is critical for its application in various fields, especially in drug formulation. As stated, "Solubility is key in determining the bioavailability of pharmaceuticals." Thus, identifying optimal solubility conditions is essential for maximizing its effectiveness in therapeutic uses.

Interesting facts

Interesting Facts about [4-(2-Pyridyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone

The compound [4-(2-pyridyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone is an intriguing example within the realm of medicinal chemistry. It belongs to a class of compounds that exhibit significant biological activity, making them valuable in pharmaceutical research.

Key Characteristics:

  • Biological Activity: This compound has been studied for its potential as a pharmacological agent, particularly in the context of neuropharmacology. Research has shown that it may influence serotonin receptors, which are crucial for mood regulation.
  • Structural Composition: The presence of both a piperazine ring and a pyridine moiety in its structure contributes to its ability to interact with biological targets effectively.
  • Trimethoxy Groups: The 3,4,5-trimethoxyphenyl group enhances the compound's lipid solubility, potentially improving its bioavailability.

This compound exemplifies the complexity and diversity found in organic molecules. Its unique combination of functional groups allows for various interactions in biological systems, which is crucial for the development of new therapeutic agents. As research continues, compounds like this may lead to breakthroughs in treating mental health disorders and other conditions influenced by neurotransmitter systems.

Research Potential:

Ongoing studies are exploring not only the mechanisms of action but also the synergy between similar compounds, which could pave the way for developing more effective treatments. Scientists are particularly interested in:

  • Structure-Activity Relationship (SAR): Understanding how different structural modifications can influence activity.
  • Pharmacokinetics: Examining how the body absorbs, distributes, metabolizes, and excretes this compound.
  • Toxicology: Assessing safety profiles to ensure therapeutic efficacy without adverse effects.

In conclusion, [4-(2-pyridyl)piperazin-1-yl]-(3,4,5-trimethoxyphenyl)methanone stands as a testament to the intricate relationship between chemical structure and biological function. Its study not only enriches our understanding of chemical sciences but also holds the promise of advancing modern medicine.

Synonyms
17766-77-7
4-(2-Pyridyl)piperazinyl 3,4,5-trimethoxyphenyl ketone
BRN 1601185
KETONE, 4-(2-PYRIDYL)PIPERAZINYL 3,4,5-TRIMETHOXYPHENYL
1-(3,4,5-Trimethoxybenzoyl)-4-(2-pyridyl)piperazine
Piperazine, 1-(2-pyridyl)-4-(3,4,5-trimethoxybenzoyl)-
DTXSID10170364
5-23-03-00029 (Beilstein Handbook Reference)
DTXCID2092855
(4-pyridin-2-ylpiperazin-1-yl)-(3,4,5-trimethoxyphenyl)methanone
MLS001210948
SMR000518691
(4-Pyridin-2-yl-piperazin-1-yl)-(3,4,5-trimethoxy-phenyl)-methanone
[4-(2-pyridinyl)-1-piperazinyl]-(3,4,5-trimethoxyphenyl)methanone
Oprea1_017055
Oprea1_374133
cid_28761
1-(2-Pyridyl)-4-(3,4,5-trimethoxybenzoyl)piperazine
CHEMBL1404540
BDBM69691
CHEBI:94210
HMS2816L14
AKOS000643532
NCGC00245374-01
EU-0099612
ST50017453
VU0151509-1
AB00110443-01
SR-01000594870
SR-01000594870-1
BRD-K84102257-001-05-7
BRD-K84102257-001-08-1
Q27165981
[4-(2-pyridyl)piperazino]-(3,4,5-trimethoxyphenyl)methanone