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Terbutaline

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Identification
Molecular formula
C12H19NO3
CAS number
23031-25-6
IUPAC name
4-[2-(tert-butylamino)-1-hydroxy-ethyl]benzene-1,2-diol
State
State

Terbutaline is typically found in a solid state at room temperature, often as a sulfate salt in pharmaceutical formulations.

Melting point (Celsius)
119.00
Melting point (Kelvin)
392.15
Boiling point (Celsius)
145.00
Boiling point (Kelvin)
418.15
General information
Molecular weight
225.30g/mol
Molar mass
225.2950g/mol
Density
1.1990g/cm3
Appearence

Terbutaline sulfate appears as a white to off-white crystalline powder. It is odorless and soluble in water.

Comment on solubility

Solubility of 4-[2-(tert-butylamino)-1-hydroxy-ethyl]benzene-1,2-diol (C12H19NO3)

The compound 4-[2-(tert-butylamino)-1-hydroxy-ethyl]benzene-1,2-diol exhibits unique solubility characteristics that are influenced by its structure. Understanding its solubility can provide insights into its potential applications and behavior in various environments.

General Solubility Insights

  • Polarity: The presence of hydroxyl (–OH) groups in the compound increases its polarity, suggesting potential solubility in polar solvents such as water.
  • Hydrophobicity: The tert-butyl group contributes a degree of hydrophobicity, which may limit solubility in highly polar solvents.
  • Solvent Compatibility: It may show good solubility in mixed solvents or organic solvents that can interact favorably with both the polar and non-polar parts of the molecule.

In practical terms, one might expect:

  • A higher solubility in aqueous solutions under acidic conditions, where the –OH groups may be protonated, enhancing interactions with water.
  • Reduced solubility in non-polar solvents due to the bulky tert-butyl group, which repels interactions with non-polar molecules.

Overall, the solubility of this compound can be summarized as *moderate*, impacted by both its polar and hydrophobic features. It is important to note that actual solubility may vary based on specific conditions such as temperature and the presence of other solutes.

Interesting facts

Interesting Facts about 4-[2-(tert-butylamino)-1-hydroxy-ethyl]benzene-1,2-diol

This fascinating compound, commonly referred to as a derivative of benzene, showcases the incredible versatility of organic chemistry. Here are some intriguing facets worth noting:

  • Structure and Functionality: The compound features a complex structure that includes a benzene ring with hydroxyl groups, showcasing its potential for hydrogen bonding and its reactivity.
  • Biological Relevance: Compounds similar to this one have been studied for their potential activity in biological systems, including roles in medicinal chemistry where they may act as pharmaceuticals or bioactive molecules.
  • Amine Component: The presence of a tert-butylamino group suggests that this compound possesses unique steric and electronic properties, which can influence its behavior in various chemical reactions.
  • Applications: Researchers are often interested in such compounds for their potential applications in drug design, particularly in modulating biological activity due to their functional groups.
  • Research Potential: This compound is a great candidate for further study to understand how modifications to its structure can affect its therapeutic properties.

In summary, 4-[2-(tert-butylamino)-1-hydroxy-ethyl]benzene-1,2-diol is not just a chemical entity—it's a window into the vast possibilities within organic synthesis and medicinal chemistry. As scientists continue to investigate its properties and applications, we may uncover even more about its role in the world of chemistry.

Synonyms
Colterol
18866-78-9
Colterolum
Colterol [INN]
(+-)-N-tert-Butylarterenol
(+-)-N-t-Butylnoradrenaline
4-[2-(tert-butylamino)-1-hydroxyethyl]benzene-1,2-diol
Colterolum [INN-Latin]
dl-N-tert-Butylnorepinephrine
UNII-1WH11068UO
(+-)-tert-Butyl noradrenaline
CHEBI:73085
1WH11068UO
KWD 2026
WIN-5563
DTXSID40864860
S 1541
S-1541
dl-1-(3,4-Dihydroxyphenyl)-2-tert-butylaminoethanol
Colterolum (INN-Latin)
1,2-Benzenediol, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-
1,2-Benzenediol, 4-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-,(+-)-
Benzyl alcohol, alpha-((tert-butylamino)methyl)-3,4-dihydroxy-, (+-)-
N-t-Butylarterenol
t-Butylnorepinephrine
4-(2-(tert-Butylamino)-1-hydroxyethyl)benzene-1,2-diol
DTXCID60813330
4-(2-((1-Dimethylethyl)amino)-1-hydroxyethyl)-1,2-benzenediol
(+-)-.ALPHA.-((TERT-BUTYLAMINO)METHYL)-3,4-DIHYDROXYBENZYL ALCOHOL
(+-)-ALPHA-((TERT-BUTYLAMINO)METHYL)-3,4-DIHYDROXYBENZYL ALCOHOL
1,2-BENZENEDIOL, 4-(2-)((1,1-DIMETHYLETHYL)AMINO)-1-HYDROXYETHYL)-(+-)-
(+/-)-N-tert-butylarterenol
KWD-2026
Win 5563
SCHEMBL249585
CHEMBL1159715
WDC59808
BDBM50421728
DB-065649
HY-128510
NS00124353
Q27140291
a-[(t-butylamino)methyl]-3,4-dihydroxy-benzyl alcohol
(+/-)-.ALPHA.-((TERT-BUTYLAMINO)METHYL)-3,4-DIHYDROXYBENZYL ALCOHOL
1,2-BENZENEDIOL, 4-(2-)((1,1-DIMETHYLETHYL)AMINO)-1-HYDROXYETHYL)- (+/-)-