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Terbutaline

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Identification
Molecular formula
C12H19NO3
CAS number
23031-32-5
IUPAC name
4-[2-(tert-butylamino)-1-hydroxy-ethyl]phenol
State
State

At room temperature, Terbutaline is a solid.

Melting point (Celsius)
118.00
Melting point (Kelvin)
391.15
Boiling point (Celsius)
350.00
Boiling point (Kelvin)
623.15
General information
Molecular weight
225.30g/mol
Molar mass
225.3010g/mol
Density
1.1888g/cm3
Appearence

Terbutaline is a white to off-white crystalline powder. It appears as a solid under standard conditions and is typically odorless.

Comment on solubility

Solubility of 4-[2-(tert-butylamino)-1-hydroxy-ethyl]phenol

The solubility of 4-[2-(tert-butylamino)-1-hydroxy-ethyl]phenol in various solvents is influenced by its unique structural features. This compound exhibits both hydrophilic and hydrophobic characteristics due to the presence of the hydroxy and tert-butylamino groups, which leads to interesting solubility behaviors.

Solubility Overview:

  • In Water: The compound is likely to show limited solubility in water, given that bulky alkyl groups can hinder interaction with water molecules.
  • In Organic Solvents: It may dissolve more readily in non-polar organic solvents like hexane or toluene due to the hydrophobic tert-butyl group.
  • In Alcohols: Solubility in alcohols such as ethanol or methanol may be enhanced as these solvents can interact with the hydroxy group more effectively.

It is important to note that the solubility can be affected by several factors including temperature, concentration, and the presence of other compounds in solution. A key point to remember is that the solubility of complex organic molecules like 4-[2-(tert-butylamino)-1-hydroxy-ethyl]phenol often requires empirical investigation for precise determinations. Generally, the understanding of solubility trends in such compounds can be summarized with the phrase:

"Like dissolves like."

Consequently, while the hydrophilic components promote interactions with polar solvents, the bulky hydrophobic portions may lead to increased solubility challenges in aqueous media.

Interesting facts

Interesting Facts about 4-[2-(tert-butylamino)-1-hydroxy-ethyl]phenol

4-[2-(tert-butylamino)-1-hydroxy-ethyl]phenol, often referred to in research circles for its intriguing chemical structure and properties, is a fascinating compound that embodies various functional groups working in tandem. Here are some noteworthy aspects:

  • Biological Applications: This compound is recognized for its potential therapeutic applications, particularly in the realm of medicinal chemistry. Its structural characteristics can mimic biological molecules, making it useful in drug design and development.
  • Antioxidant Properties: One of the most exciting functions of this compound is its ability to act as an antioxidant. Compounds with similar structures are often studied for their capacity to neutralize free radicals, which are known to cause oxidative stress in biological systems.
  • Research in Organic Synthesis: The presence of the tert-butylamino and hydroxy groups facilitates various organic synthesis pathways, making this compound a valuable intermediate in the production of other complex molecules.
  • Structure-Activity Relationship: The unique arrangement of its functional groups allows chemists to study the structure-activity relationship, which is key in understanding how changes in molecular structure can influence biological activity.
  • Environmental Significance: Its derivatives are sometimes investigated for their environmental impact and degradation pathways, particularly in the field of environmental chemistry.

Overall, 4-[2-(tert-butylamino)-1-hydroxy-ethyl]phenol is more than just a chemical; it stands at the intersection of chemistry and biology, providing insights that push the boundaries of scientific knowledge. As a reminder of how complex molecules can play pivotal roles in both health and science, it is a compound worth exploring further.

Synonyms
t-Butylnorsynephrine
Salbutamol EP Impurity B
4RM5R3DQXG
BUCTOPAMINE
DTXSID90914243
SALBUTAMOL IMPURITY B [EP IMPURITY]
SALBUTAMOL SULFATE IMPURITY B [EP IMPURITY]
(1RS)-2-[(1,1-Dimethylethyl)amino]-1-(4-hydroxyphenyl)ethanol
alpha-[[(1,1-Dimethylethyl)amino]methyl]-4-hydroxybenzenemethanol
(1RS)-2-((1,1-DIMETHYLETHYL)AMINO)-1-(4-HYDROXYPHENYL)ETHANOL
.ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-4-HYDROXYBENZENEMETHANOL
SALBUTAMOL IMPURITY B (EP IMPURITY)
SALBUTAMOL SULFATE IMPURITY B (EP IMPURITY)
ALPHA-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-4-HYDROXYBENZENEMETHANOL
DTXCID501343238
BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-4-HYDROXY-, (+-)-
Benzenemethanol, alpha-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, (+-)-
642-018-7
96948-64-0
4-[2-(tert-butylamino)-1-hydroxyethyl]phenol
7376-67-2
Kwd-2066
CHEMBL1159887
tert-Butylnorsynephrine
4-(2-(tert-Butylamino)-1-hydroxyethyl)phenol
Salbutamol Impurity B
UNII-4RM5R3DQXG
BRN 3260793
Kwd 2066
Salbutamol Sulphate Imp. B (EP); Salbutamol Imp. B (EP); (1RS)-2-[(1,1-Dimethylethyl)amino]-1-(4-hydroxyphenyl)ethanol; Salbutamol Impurity B; Salbutamol Sulfate Impurity B; Salbutamol Impurity B
alpha-(tert-Butylaminomethyl)-p-hydroxybenzyl alcohol
Benzenemethanol, alpha-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-
3-13-00-02243 (Beilstein Handbook Reference)
Salbutamol sulphate impurity B
SCHEMBL6464765
BENZYL ALCOHOL, alpha-((tert-BUTYLAMINO)METHYL)-p-HYDROXY-
BDBM50421733
STL454224
FS63825
N-t-butyl-2-(4-hydroxyphenyl)-2-hydroxyethyl-amine
Q27260403
BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-4-HYDROXY-
BENZENEMETHANOL, .ALPHA.-(((1,1-DIMETHYLETHYL)AMINO)METHYL)-4-HYDROXY-, (+/-)-