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N-acetyl-L-gamma-glutamyl-L-leucine

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Identification
Molecular formula
C10H19NO5
CAS number
63914-39-2
IUPAC name
4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid
State
State

At room temperature, this compound is typically in a solid state.

Melting point (Celsius)
145.00
Melting point (Kelvin)
418.15
Boiling point (Celsius)
256.00
Boiling point (Kelvin)
529.15
General information
Molecular weight
233.28g/mol
Molar mass
233.2750g/mol
Density
1.2189g/cm3
Appearence

The compound is typically found as a crystalline powder that is white to off-white in color.

Comment on solubility

Solubility of 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid

The solubility of 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid is influenced by several factors due to its unique structure.

  • Polarity: This compound has multiple hydroxyl groups (-OH) which enhance its polarity, allowing it to interact effectively with polar solvents like water.
  • Hydrogen Bonding: The presence of hydroxyl and amino groups facilitates hydrogen bonding, improving its solubility in polar media.
  • Concentration: Its solubility may vary significantly with concentration; higher concentrations can lead to decreased solubility due to intermolecular interactions.
  • pH Dependence: As a carboxylic acid, its solubility may also be affected by the pH of the solution, potentially increasing in basic conditions.

In summary, one could generally expect 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid to exhibit good solubility in polar solvents and moderate solubility in organic solvents. However, extensive experimental data would be essential to provide a precise solubility profile under varying conditions.

Interesting facts

Interesting Facts About 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic Acid

4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid, often referred to in the context of biological and chemical research, is a compound that demonstrates a unique structure and function, particularly in biochemistry. Here are some notable aspects:

  • Structural Complexity: The compound features a multi-substituted butanoic acid backbone that includes hydroxyl groups and an amino function. This structural diversity allows it to interact with biological systems in various ways, influencing enzymatic activities and molecular recognition.
  • Biological Significance: Due to its potential roles as a biochemical precursor or an inhibitor, it has garnered interest in medicinal chemistry. Researchers are exploring its implications in metabolic pathways, especially concerning amino acid synthesis and its therapeutic actions.
  • Potential Applications: This compound might be investigated for its potential as a therapeutic agent in treating metabolic disorders. With the rising focus on personalized medicine, compounds such as 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid can be critical in developing targeted therapies based on an individual’s chemical makeup.
  • Chirality in Action: The “(2R)” designation signifies that this compound displays chirality, which is crucial in biochemistry. The 'R' and 'S' configurations can greatly affect a compound's biological activity, including receptor binding and metabolism.
  • Research Frontiers: Current research may involve this compound's synthesis and characterization using advanced techniques such as NMR and X-ray crystallography. Understanding its interactions at the molecular level can lead to exciting discoveries in biochemical pathways.

As scientific exploration continues, the nuanced roles and applications of compounds like 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid will likely offer new insights and opportunities in chemical science.

Synonyms
Hopantenic acid
18679-90-8
D-Homopantothenic acid
Pantocalcin
Hopanteninsaeure
Acido hopantenico
Acide hopantenique
Hopantenic acid [INN]
Acidum hopantenicum
Acide hopantenique [INN-French]
Acido hopantenico [INN-Spanish]
Acidum hopantenicum [INN-Latin]
N-pantoyl-GABA
UNII-H473MVB16U
Pantocalcin (TN)
Hopantenic acid (INN)
D-(+)-4-(2,4-Dihydroxy-3,3-dimethylbutyramido)butyric acid
HOPANTENIC ACID [MI]
DTXSID6048331
HOPANTENIC ACID [WHO-DD]
(R)-(+)-4-(2,4-Dihydroxy-3,3-dimethylbutyramido)buttersaeure
BUTYRIC ACID, 4-(2,4-DIHYDROXY-3,3-DIMETHYLBUTYRAMIDO)-, D-(+)-
Acide hopantenique (INN-French)
Acido hopantenico (INN-Spanish)
Acidum hopantenicum (INN-Latin)
4-[(2R)-2,4-dihydroxy-3,3-dimethylbutanamido]butanoic acid
4-(((2R)-2,4-DIHYDROXY-3,3-DIMETHYL-1-OXOBUTYL)AMINO)BUTANOIC ACID
4-((2R)-2,4-dihydroxy-3,3-dimethylbutanamido)butanoic acid
pantogab, (R)-isomer
DTXCID7028306
Hopantenic
(R)-4-(2,4-Dihydroxy-3,3-dimethylbutanamido)butanoic acid
HOPan
4-[[(2R)-2,4-dihydroxy-3,3-dimethylbutanoyl]amino]butanoic acid
H473MVB16U
Dexpanthenol impurity I
Calicum hopantenate
Dexpanthenol Impurity 2
4-[(2,4-Dihydroxy-3,3-dimethylbutanoyl)amino]-butanoic acid
4-[(2,4-Dihydroxy-3,3-dimethyl-1-oxobutyl)amino]butanoic acid
orb1691414
SCHEMBL1649293
CHEMBL2110783
CHEBI:134949
SBBDHANTMHIRGW-QMMMGPOBSA-N
ALBB-038666
SBB080738
AKOS005267205
DB14044
HY-139729
CS-0254878
NS00068807
D08042
F87812
SBI-0654639.0001
Q4143336
4-((2R)-2,4-dihydroxy-3,3-dimethylbutanoylamino)butanoic acid
4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-butanoyl]amino]butanoic acid
Butanoic acid, 4-[[(2R)-2,4-dihydroxy-3,3-dimethyl-1-oxobutyl]amino]-