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Lapatinib

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Identification
Molecular formula
C29H26ClFN4O4S
CAS number
231277-92-2
IUPAC name
[4-[3-[(6,7-diethoxyquinazolin-4-yl)amino]phenyl]thiazol-2-yl]methanol
State
State

At room temperature, Lapatinib is in a solid state, typically appearing as a crystalline powder.

Melting point (Celsius)
137.50
Melting point (Kelvin)
410.65
Boiling point (Celsius)
770.00
Boiling point (Kelvin)
1 043.15
General information
Molecular weight
581.06g/mol
Molar mass
581.0580g/mol
Density
1.2118g/cm3
Appearence

Lapatinib is typically found as a yellow or pale yellow powder. It is commonly administered as an oral tablet in its pharmaceutical form for medical use.

Comment on solubility

Solubility Characteristics

The solubility of the compound [4-[3-[(6,7-diethoxyquinazolin-4-yl)amino]phenyl]thiazol-2-yl]methanol: C29H26ClFN4O4S can be influenced by a variety of factors. Understanding these factors can provide insights into its behavior in different environments.

Factors Influencing Solubility

  • Polarity: The presence of polar functional groups such as hydroxyl (-OH) and ether (R-O-R') can enhance solubility in polar solvents.
  • Hydrogen Bonding: The ability to form hydrogen bonds with solvent molecules can improve solubility, particularly in water.
  • Molecular Size: Larger molecules often exhibit decreased solubility due to steric hindrance and reduced interaction with solvent.
  • Temperature: Increasing temperature can generally increase solubility; however, this can vary depending on the dissolution enthalpy.
  • pH: The solubility of organic compounds can also change with pH, particularly for those with ionizable groups.

In summary, while the compound has a complex structure that likely impacts its solubility, the interplay of its non-polar and polar components is crucial. As stated, "The solubility in polar solvents can be enhanced by the compound's functional groups," emphasizing the need for a careful evaluation of solvent compatibility for this specific compound.

Interesting facts

Interesting Facts about 4-[3-[(6,7-diethoxyquinazolin-4-yl)amino]phenyl]thiazol-2-yl]methanol

The compound 4-[3-[(6,7-diethoxyquinazolin-4-yl)amino]phenyl]thiazol-2-yl]methanol is a fascinating example of a hybrid structure in medicinal chemistry. Here are some intriguing insights:

  • Diverse applications: The structural complexity of this compound provides opportunities for various therapeutic applications, particularly in the areas of cancer research and drug development.
  • Quinazoline derivatives: This compound features a quinazoline core, which has been extensively studied for its biological activities, including anticancer and antibacterial properties.
  • Thiazole moiety: The incorporation of a thiazole ring further enhances the compound's pharmacological potential, as thiazoles are known for their efficacy in diverse treatments such as antimicrobials and anti-inflammatory agents.
  • Synergistic effects: By combining a quinazoline with a thiazole, researchers aim to exploit potential synergistic effects, which could lead to more potent and selective interactions at the molecular level.
  • Structural diversity: The presence of diethoxy groups provides versatility in modifying the compound's physio-chemical properties, potentially leading to improved solubility and bioavailability.

As stated by many researchers in the field, "The development of multi-functional compounds like this one may pave the way for new strategies in overcoming drug resistance in cancer treatment." The exploration of such compounds remains a key focus in medicinal chemistry.

Overall, 4-[3-[(6,7-diethoxyquinazolin-4-yl)amino]phenyl]thiazol-2-yl]methanol is a prime candidate for further research, promising to enhance our understanding of complex interactions within biological systems and shape future therapeutic pathways.

Synonyms
{4-[3-(6,7-diethoxy-quinazolin-4-ylamino)-phenyl]-thiazol-2-yl}-methanol
CHEMBL123678
(4-{3-[(6,7-diethoxyquinazolin-4-yl)amino]phenyl}-1,3-thiazol-2-yl)methanol
(4-(3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl)-Thiazol-2-Yl)-Methanol
(4-(3-((6,7-diethoxyquinazolin-4-yl)amino)phenyl)-1,3-thiazol-2-yl)methanol
1kz8
PFE
SCHEMBL4315736
BDBM50117957
DB02848
PD007586
NS00068978
Q27093810