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Endothelin

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Identification
Molecular formula
C203H314N56O64S1
CAS number
117399-94-7
IUPAC name
4-[[3-amino-2-[[2-[[2-[(2,3-dihydroxy-2,6,8-trimethyl-deca-4,6-dienoyl)amino]acetyl]amino]-3-hydroxy-butanoyl]amino]butanoyl]amino]-N'-[6-(1-hydroxyethyl)-3-[(4-hydroxyphenyl)-methoxy-methyl]-19-isopropyl-15-(methoxymethyl)-9-methyl-2,5,8,11,14,17,21-heptaoxo-20-oxa-1,4,7,10,13,16-hexazabicyclo[20.4.0]hexacosan-18-yl]-2,3-dimethyl-pentanediamide
State
State

Endothelin is typically in a solid state at room temperature, usually prepared as a lyophilized powder that is stable under various laboratory conditions.

Melting point (Celsius)
125.00
Melting point (Kelvin)
398.15
Boiling point (Celsius)
180.00
Boiling point (Kelvin)
453.15
General information
Molecular weight
5126.20g/mol
Molar mass
5 126.2000g/mol
Density
1.2000g/cm3
Appearence

Endothelin typically appears as a white to off-white powder. It is a peptide with significant bioactivity, often utilized in a laboratory setting for biological and biochemical assays.

Comment on solubility

Solubility of 4-[[3-amino-2-[[2-[[2-[(2,3-dihydroxy-2,6,8-trimethyl-deca-4,6-dienoyl)amino]acetyl]amino]-3-hydroxy-butanoyl]amino]butanoyl]amino]-N'-[6-(1-hydroxyethyl)-3-[(4-hydroxyphenyl)-methoxy-methyl]-19-isopropyl-15-(methoxymethyl)-9-methyl-2,5,8,11,14,17,21-heptaoxo-20-oxa-1,4,7,10,13,16-hexazabicyclo[20.4.0]hexacosan-18-yl]-2,3-dimethyl-pentanediamide

The solubility of this complex compound, with the formula C203H314N56O64S1, can be quite intricate to evaluate due to its large and multifunctional structure. Understanding its solubility involves several key factors:

  • Molecular size and weight: This compound has a significantly high molecular weight, which often correlates with lower solubility in aqueous solutions.
  • Functional groups: The presence of multiple functional groups, including amines, hydroxyls, and ethers, influences solubility. Typically, polar groups enhance solubility in polar solvents like water.
  • Hydrophobic and hydrophilic balance: The compound possesses numerous hydrophobic regions due to alkyl chains and hydrophilic areas due to polar functional groups. This dual nature can lead to solubility in mixed solvents or in certain organic solvents rather than simple aqueous solutions.
  • Temperature and pH: Solubility can be markedly affected by changes in temperature and pH, suggesting that experimental conditions should be carefully controlled to ascertain specific solubility characteristics.

In conclusion, while specific solubility data may not be readily available for this particular compound, it is prudent to consider that its solubility is likely limited in water, but potentially greater in organic solvents due to structural complexity and the presence of diverse functional groups. This necessitates further empirical studies to fully elucidate its solubility profile in various media.

Interesting facts

Interesting Facts about 4-[[3-amino-2-[[2-[[2-[(2,3-dihydroxy-2,6,8-trimethyl-deca-4,6-dienoyl)amino]acetyl]amino]-3-hydroxy-butanoyl]amino]butanoyl]amino]-N'-[6-(1-hydroxyethyl)-3-[(4-hydroxyphenyl)-methoxy-methyl]-19-isopropyl-15-(methoxymethyl)-9-methyl-2,5,8,11,14,17,21-heptaoxo-20-oxa-1,4,7,10,13,16-hexazabicyclo[20.4.0]hexacosan-18-yl]-2,3-dimethyl-pentanediamide

This complex compound represents the forefront of medicinal chemistry, showcasing the intricate world of amino acids and their derivatives. With an extensive structure, this molecule features numerous key functionalities that can significantly influence biological activity, making it a topic of interest in both academic and pharmaceutical fields.

  • Multi-functional Groups: The compound contains various functional groups including amino, hydroxy, and methoxy, which play vital roles in its reactivity and interaction with biological systems.
  • Potential Applications: Given its structure, this compound may hold promise in drug design, particularly in targeting specific biomolecular pathways, potentially aiding in the development of novel therapeutics.
  • Complexity of Synthesis: The synthesis of such a compound poses a significant challenge. It often requires a series of intricate reactions and careful manipulation of conditions to achieve the desired structure.
  • Role of Natural Products: The inclusion of elements derived from natural products, like dihydroxy groups, often suggests bioactivity and can contribute to the compound's efficacy as a medicinal agent.

As noted by chemists, "the complexity of a molecule is often indicative of its potential application in therapeutics." This compound is a testament to that notion, encouraging further research to uncover the mechanisms by which it could exert its effects.

In summary, the exploration of this compound opens doors to understanding its potential in drug development, highlighting the beauty and sophistication of chemical structure-function relationships in pharmacology.