Loperamide | Solubility of Things

Identification

Molecular formula

C₂₉H₃₃ClFN₂O₂

CAS number

34552-83-5

IUPAC name

4-(3-azabicyclo[3.2.2]nonan-1-yl)-1-(4-fluorophenyl)butan-1-one

State

At room temperature, loperamide is in a solid state. It is typically found in the form of a powder which is used in pharmaceutical preparations.

Melting point (Celsius)

214.00

Melting point (Kelvin)

487.15

Boiling point (Celsius)

494.10

Boiling point (Kelvin)

767.25

General information

Molecular weight

477.03g/mol

Molar mass

477.0320g/mol

Density

0.8100g/cm³

Appearence

The compound typically appears as a white or off-white crystalline powder. It is odorless and has a slightly bitter taste.

Comment on solubility

Solubility of 4-(3-azabicyclo[3.2.2]nonan-1-yl)-1-(4-fluorophenyl)butan-1-one

The solubility of 4-(3-azabicyclo[3.2.2]nonan-1-yl)-1-(4-fluorophenyl)butan-1-one can be influenced by several factors including its chemical structure, the presence of functional groups, and the solvent used. While the exact solubility data may not be readily available for this specific compound, we can consider several points regarding its solubility characteristics:

Polarity: The compound contains polar functional groups that may enhance its solubility in polar solvents.
Hydrogen Bonding: The potential for hydrogen bonding can also play a significant role, leading to an increased solubility in protic solvents.
Solvent Interaction: The presence of a fluorine atom may affect its interaction with various solvents, possibly leading to unique solubility properties in fluorinated solvents.
Temperature Dependency: Like many organic compounds, solubility may increase with temperature, making it essential to consider when conducting experiments.

In conclusion, while direct solubility data for 4-(3-azabicyclo[3.2.2]nonan-1-yl)-1-(4-fluorophenyl)butan-1-one may be limited, understanding its molecular structure offers insight into its likely solubility in different solvents. As always, experimental verification is recommended to determine the precise solubility under various conditions. "The key to solubility is understanding the ‘like dissolves like’ principle."

Interesting facts

Interesting Facts about 4-(3-azabicyclo[3.2.2]nonan-1-yl)-1-(4-fluorophenyl)butan-1-one

This intriguing compound belongs to a class known as pharmacologically active substances, which play a significant role in medicinal chemistry. One of the notable aspects of this compound is its unique bicyclic structure, specifically the 3-azabicyclo[3.2.2]nonane moiety, which contributes to its distinctive biological activity. Here are some interesting points:

Structural Complexity: The presence of a bicyclic structure is often associated with enhanced binding affinity to biological targets, making it a subject of interest in drug discovery.
Fluorine Substitution: The incorporation of a fluorine atom in the 4-fluorophenyl group often enhances a compound's metabolic stability and bioavailability.
Potential Applications: Compounds of this nature are frequently investigated for their potential as neuropharmacological agents, which means they could influence neurological functions and are considered for treating psychiatric conditions.
Research Interest: Due to its complex structure and potential medicinal properties, this compound is likely to be a topic in various chemistry journals focused on drug design and development.

As researchers delve deeper into the characteristics of such compounds, they uncover fascinating connections between structure and function, which is central to advancements in the field of medicinal chemistry. This compound exemplifies the *intricate dance* between chemical structure and biological activity!